Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Cele Abad-Zapatero"'
Autor:
James B. McAlpine, Guido F. Pauli, Shao-Nong Chen, Hyun Lee, Joo-Won Suh, Cele Abad-Zapatero, Nina M. Wolf, Sang-Hyun Cho, Bin Zhou, Scott G. Franzblau, Gauri Shetye, Jonathan Bisson, Hanki Lee, Yang Yu, Jinhua Cheng, Larry L. Klein, Ying-Yu Jin, Bernard D. Santarsiero
Publikováno v:
J Nat Prod
This study represents a systematic chemical and biological study of the rufomycin (RUF) class of cyclic heptapeptides, which our anti-TB drug discovery efforts have identified as potentially promising anti-TB agents that newly target the caseinolytic
Autor:
Cele Abad-Zapatero, Nuria B. Centeno, Ellen Y. Cotrina, Jordi Quintana, Daniel Blasi, Marta Vila, Antoni Planas, Gemma Arsequell
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
In the past few years, attempts have been made to use decision criteria beyond Lipinski’s guidelines (Rule of five) to guide drug discovery projects more effectively. Several variables and formulations have been proposed and investigated within the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee9d96da3a99b1a1a029382c9abd1ca0
http://hdl.handle.net/10261/222524
http://hdl.handle.net/10261/222524
Autor:
Ryan Patwell, Ram Samudrala, Maxwell Wiley Rutter, Cele Abad-Zapatero, Alexey Dementiev, Hiten J. Gutka, Shahila Mehboob, Farahnaz Movahedzadeh, Mashal M. Almutairi, Nina M. Wolf, Jasper Marc G. Bondoc
Publikováno v:
Acta Crystallogr F Struct Biol Commun
Acyl carrier proteins (ACPs) are important components in fatty-acid biosynthesis in prokaryotes. Rv0100 is predicted to be an essential ACP in Mycobacterium tuberculosis, the pathogen that is the causative agent of tuberculosis, and therefore has the
Autor:
Cele Abad-Zapatero
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 70:907-911
The magnificent rose windows of the Gothic cathedrals provide artistic illustrations of many of the planar point groups of symmetry. It is suggested that the presence of certain symmetry elements and their selection by the artists could have been mot
Publikováno v:
Molecular informatics. 30(2-3)
Autor:
Cele Abad-Zapatero, Anil Vasudevan, Clara I. Villamil, Kent D. Stewart, Tetsuro Oie, Mary K. Verzal, Stevan W. Djuric
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4502-4505
The design and synthesis of indazolinone containing kinase inhibitors are reported. Regioisomers that showed profound potency variation in previously-reported isoindolinone and aminoindazole systems were surprisingly found to have similar potencies i
Autor:
Joan Pous, S. Rodriguez-Puente, R. Oliete, Alicia Guasch, Michael E. Johnson, L. Martinelli, Cele Abad-Zapatero
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
et al.
The use of relative humidity control of protein crystals to overcome some of the shortcomings of soaking ligands (i.e. inhibitors, substrate analogs, weak ligands) into pre-grown apoprotein crystals has been explored. Crystals of PurE (EC
The use of relative humidity control of protein crystals to overcome some of the shortcomings of soaking ligands (i.e. inhibitors, substrate analogs, weak ligands) into pre-grown apoprotein crystals has been explored. Crystals of PurE (EC
Autor:
Cele Abad-Zapatero, Daniel Blasi
Publikováno v:
Molecular Informatics. 30:122-132
The concept of ligand efficiency and the usage of ligand efficiency values to assess the quality of fragments and compounds is becoming more accepted in the practice of medicinal chemistry. This is particularly true as it refers to the efficiency of
Publikováno v:
Molecular Informatics. 30:137-144
Autor:
Cele Abad-Zapatero, Yong Jia, David J. Burns, Timothy E. Cloutier, Zhili Xin, Douglas Marcotte, Hua Tang, Kenneth M. Comess, Teresa I. Ng, David W. Borhani, Michael L. Coen, Sanyi Wang, Harriet T. Smith, Eric R. Goedken, Danying Song, Jill E. Clampit, Bo Liu, Philip J. Hajduk, Xueheng Cheng, Maria A. Argiriadi, David Banach, Chaohong Sun, Duncan R. Groebe, Elizabeth H. Fry, Christopher Quinn, Gang Liu, David J. Calderwood, Deanna L. Haasch, Vincent S. Stoll, Rebecca J. Gum
Publikováno v:
ACS Chemical Biology. 6:234-244
Inhibition of protein kinases has validated therapeutic utility for cancer, with at least seven kinase inhibitor drugs on the market. Protein kinase inhibition also has significant potential for a variety of other diseases, including diabetes, pain,