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Akademický článek

Evaluation of a stabilized RSV pre-fusion F mRNA vaccine: Preclinical studies and Phase 1 clinical testing in healthy adults.

Autor: Nussbaum J; Merck & Co., Inc., Rahway, NJ, USA. Electronic address: jesse.nussbaum@merck.com., Cao X; Merck & Co., Inc., Rahway, NJ, USA., Railkar RA; Merck & Co., Inc., Rahway, NJ, USA., Sachs JR; Merck & Co., Inc., Rahway, NJ, USA., Spellman DS; Merck & Co., Inc., Rahway, NJ, USA., Luk J; Merck & Co., Inc., Rahway, NJ, USA., Shaw CA; Moderna Inc., Cambridge, MA, USA., Cejas PJ; Merck & Co., Inc., Rahway, NJ, USA., Citron MP; Merck & Co., Inc., Rahway, NJ, USA., Al-Ibrahim M; Pharmaron, Baltimore, MD, USA., Han D; Parexel, Glendale, CA, USA., Pagnussat S; QPS, Miami, FL, USA., Stoch SA; Merck & Co., Inc., Rahway, NJ, USA., Lai E; Merck & Co., Inc., Rahway, NJ, USA., Bett AJ; Merck & Co., Inc., Rahway, NJ, USA., Espeseth AS; Merck & Co., Inc., Rahway, NJ, USA.

Publikováno v: Vaccine [Vaccine] 2023 Oct 20; Vol. 41 (44), pp. 6488-6501. Date of Electronic Publication: 2023 Sep 29.

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Akademický článek

Characterization of humoral and cell-mediated immunity induced by mRNA vaccines expressing influenza hemagglutinin stem and nucleoprotein in mice and nonhuman primates.

Autor: Flynn JA; Merck & Co., Inc., Kenilworth, NJ, USA. Electronic address: jessica_flynn@merck.com., Weber T; Merck & Co., Inc., Kenilworth, NJ, USA., Cejas PJ; Spark Therapeutics, Inc, USA(1)., Cox KS; Merck & Co., Inc., Kenilworth, NJ, USA., Touch S; Merck & Co., Inc., Kenilworth, NJ, USA., Austin LA; Merck & Co., Inc., Kenilworth, NJ, USA., Ou Y; Merck & Co., Inc., Kenilworth, NJ, USA., Citron MP; Merck & Co., Inc., Kenilworth, NJ, USA., Luo B; Merck & Co., Inc., Kenilworth, NJ, USA., Gindy ME; Merck & Co., Inc., Kenilworth, NJ, USA., Bahl K; Moderna, Inc., Cambridge, MA, USA., Ciaramella G; Beam Therapeutics, USA(1)., Espeseth AS; Merck & Co., Inc., Kenilworth, NJ, USA., Zhang L; Merck & Co., Inc., Kenilworth, NJ, USA. Electronic address: lan_zhang2@merck.com.

Publikováno v: Vaccine [Vaccine] 2022 Jul 30; Vol. 40 (32), pp. 4412-4423. Date of Electronic Publication: 2022 Jun 06.

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Akademický článek

Upper and lower respiratory tract correlates of protection against respiratory syncytial virus following vaccination of nonhuman primates.

Autor: Zohar T; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Hsiao JC; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Mehta N; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Das J; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Devadhasan A; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Karpinski W; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Callahan C; Merck & Co., Inc., Kenilworth, NJ 07033, USA., Citron MP; Merck & Co., Inc., Kenilworth, NJ 07033, USA., DiStefano DJ; Merck & Co., Inc., Kenilworth, NJ 07033, USA., Touch S; Merck & Co., Inc., Kenilworth, NJ 07033, USA., Wen Z; Merck & Co., Inc., Kenilworth, NJ 07033, USA., Sachs JR; Merck & Co., Inc., Kenilworth, NJ 07033, USA., Cejas PJ; Merck & Co., Inc., Kenilworth, NJ 07033, USA., Espeseth AS; Merck & Co., Inc., Kenilworth, NJ 07033, USA., Lauffenburger DA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Bett AJ; Merck & Co., Inc., Kenilworth, NJ 07033, USA. Electronic address: andrew_bett@merck.com., Alter G; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA. Electronic address: galter@mgh.harvard.edu.

Publikováno v: Cell host & microbe [Cell Host Microbe] 2022 Jan 12; Vol. 30 (1), pp. 41-52.e5. Date of Electronic Publication: 2021 Dec 07.

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Akademický článek

Modified mRNA/lipid nanoparticle-based vaccines expressing respiratory syncytial virus F protein variants are immunogenic and protective in rodent models of RSV infection.

Autor: Espeseth AS; 1ID/Vaccines Discovery, Merck & Co., Inc., Kenilworth, NJ USA., Cejas PJ; 1ID/Vaccines Discovery, Merck & Co., Inc., Kenilworth, NJ USA., Citron MP; 1ID/Vaccines Discovery, Merck & Co., Inc., Kenilworth, NJ USA., Wang D; 1ID/Vaccines Discovery, Merck & Co., Inc., Kenilworth, NJ USA., DiStefano DJ; 1ID/Vaccines Discovery, Merck & Co., Inc., Kenilworth, NJ USA., Callahan C; 1ID/Vaccines Discovery, Merck & Co., Inc., Kenilworth, NJ USA., Donnell GO; 2Pharmacology, Merck & Co., Inc., Kenilworth, NJ USA., Galli JD; 1ID/Vaccines Discovery, Merck & Co., Inc., Kenilworth, NJ USA., Swoyer R; 1ID/Vaccines Discovery, Merck & Co., Inc., Kenilworth, NJ USA., Touch S; 1ID/Vaccines Discovery, Merck & Co., Inc., Kenilworth, NJ USA., Wen Z; 1ID/Vaccines Discovery, Merck & Co., Inc., Kenilworth, NJ USA., Antonello J; 3Biostatistics, Merck & Co., Inc., Kenilworth, NJ USA., Zhang L; 1ID/Vaccines Discovery, Merck & Co., Inc., Kenilworth, NJ USA., Flynn JA; 1ID/Vaccines Discovery, Merck & Co., Inc., Kenilworth, NJ USA., Cox KS; 1ID/Vaccines Discovery, Merck & Co., Inc., Kenilworth, NJ USA., Freed DC; 1ID/Vaccines Discovery, Merck & Co., Inc., Kenilworth, NJ USA., Vora KA; 1ID/Vaccines Discovery, Merck & Co., Inc., Kenilworth, NJ USA., Bahl K; Moderna, Inc., Cambridge, MA USA., Latham AH; 5Pharmaceutical Science, Merck & Co., Inc., Kenilworth, NJ USA., Smith JS; 5Pharmaceutical Science, Merck & Co., Inc., Kenilworth, NJ USA., Gindy ME; 5Pharmaceutical Science, Merck & Co., Inc., Kenilworth, NJ USA., Ciaramella G; Moderna, Inc., Cambridge, MA USA., Hazuda D; 1ID/Vaccines Discovery, Merck & Co., Inc., Kenilworth, NJ USA., Shaw CA; Moderna, Inc., Cambridge, MA USA., Bett AJ; 1ID/Vaccines Discovery, Merck & Co., Inc., Kenilworth, NJ USA.

Publikováno v: NPJ vaccines [NPJ Vaccines] 2020 Feb 14; Vol. 5 (1), pp. 16. Date of Electronic Publication: 2020 Feb 14 (Print Publication: 2020).

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