Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Cees Olievier"'
Publikováno v:
Anesthesiology. 98:420-427
Background Tramadol hydrochloride (tramadol) is a synthetic opioid analgesic with a relatively weak affinity at opioid receptors. At analgesic doses, tramadol seems to cause little or no respiratory depression in humans, although there are some confl
Publikováno v:
The Journal of Physiology. 537:221-229
The carbonic anhydrases are a family of zinc metallo-enzymes catalysing the reversible hydration of CO2. In higher vertebrates including humans, at least 10 different carbonic anhydrase iso-enzymes have been discovered. These isoforms are characteris
Publikováno v:
Anesthesiology. 90:1119-1128
Background Inhalational anesthetics depress breathing dose dependently. The authors studied the dynamics of ventilation on changes in end-tidal sevoflurane partial pressure. To learn more about the mechanisms of sevoflurane-induced respiratory depres
Publikováno v:
Anesthesiology. 88:903-913
Background Opiate agonists have different analgesic effects in male and female patients. The authors describe the influence of sex on the respiratory pharmacology of the mu-receptor agonist morphine. Methods The study was placebo-controlled, double-b
Publikováno v:
The Journal of Physiology. 488:767-777
1. The effect of inhibition of erythrocyte carbonic anhydrase on the ventilatory response to CO2 was studied by administering benzolamide (70 mg kg-1, i.v.), an inhibitor which does not cross the blood-brain barrier, to carotid body denervated cats w
Publikováno v:
Respiration Physiology. 96:25-35
In 12 piglets aged 0-1.5 days we assessed the relative contribution of the peripheral and central chemoreceptors in mediating the ventilatory response to CO2 at three levels of arterial O2 tension using the dynamic end-tidal forcing technique. With t
Publikováno v:
Brain Research. 635:353-356
To investigate which neurons in the medulla oblongata produced the nuclear protein FOS during stimulation of respiration by hypercapnia, we subjected six anaesthetized cats to 10% CO2 in air for one hour. Four animals inhaled room air. Coronal sectio
Publikováno v:
Journal of Applied Physiology. 68:1107-1113
The dynamics of the effect of central hypoxia on ventilation were investigated by the technique of artificial perfusion of the brain stem in alpha-chloralose-urethan-anesthetized cats. A two-channel roller pump and a four-way valve allowed switching
Autor:
Cees Olievier, Denham S. Ward, Diederik Nieuwenhuijs, Raymonda Romberg, Albert Dahan, Luc J. Teppema, Elise Sarton
Publikováno v:
The Journal of physiology. 544(3)
We studied the effect of the antioxidants (AOX) ascorbic acid (2 g, I.V.) and alpha-tocopherol (200 mg, P.O.) on the depressant effect of subanaesthetic doses of halothane (0.11 % end-tidal concentration) on the acute isocapnic hypoxic ventilatory re