Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Cees J. Timmer"'
Autor:
Peter Dogterom, Dick de Vries, Pierre Peeters, Cees J Timmer, Rik de Greef, Andre van Vliet, Edwin Spaans
Publikováno v:
Clinical Pharmacology in Drug Development. 1:131-143
This double-blind, placebo-controlled, randomized study is the first in healthy volunteers to describe the safety, tolerability, and pharmacokinetics of sublingual asenapine at therapeutic dosages. After a 2-day placebo run-in phase, healthy male vol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c894c7f28c74c16011a084e82bed5b7
https://doi.org/10.1177/2160763x12455328
https://doi.org/10.1177/2160763x12455328
Publikováno v:
The Open Drug Metabolism Journal. 3:1-7
Objective: To investigate the effects of rifampin on the steady-state pharmacokinetics of gepirone and metabo- lites after multiple dosing of both drugs. Methods: 24 subjects completed a randomized crossover study with 2 study phases separated by a w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd783821c4dd92ab46160865cf076864
https://doi.org/10.2174/1874073100903010001
https://doi.org/10.2174/1874073100903010001
Autor:
Cees J. Timmer, Louis F. Fabre
Publikováno v:
Current Therapeutic Research, Vol 64, Iss 8, Pp 580-598 (2003)
Background: The new antidepressant gepirone acts preferentially on 5-hydroxytryptamine type 1A (5-HT1A) receptors and functions as a 5-HT1A agonist. Placebo-controlled clinical studies have established that gepirone has a good safety profile and is e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae7b0b47c4064c49c36a18b65361b72e
https://doi.org/10.1016/j.curtheres.2003.09.012
https://doi.org/10.1016/j.curtheres.2003.09.012
Autor:
J. M. A. Sitsen, Cees J. Timmer
Publikováno v:
Clinical Drug Investigation. 22:819-826
To determine the single- and multiple-dose pharmacokinetic profile of gepirone extended-release (ER) in healthy individuals. The single- and multiple-dose pharmacokinetics of gepirone-ER were investigated in three randomised, placebo-controlled studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc9d0803bc797b22a935cf2c3ddda668
https://doi.org/10.2165/00044011-200222120-00002
https://doi.org/10.2165/00044011-200222120-00002
Autor:
Titia M. T. Mulders, Cees J. Timmer
Publikováno v:
Clinical Pharmacokinetics. 39:233-242
To assess the pharmacokinetics of etonogestrel and ethinylestradiol released from a novel combined contraceptive vaginal ring (NuvaRing) releasing etonogestrel 120microg and ethinylestradiol 15 microg per day and compare them with those of a combined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aec18323a2e2f34bd9749bd3a6a5b76
https://doi.org/10.2165/00003088-200039030-00005
https://doi.org/10.2165/00003088-200039030-00005
Publikováno v:
Journal of Psychopharmacology. 14:172-176
A substantial proportion of patients diagnosed with depression and treated with antidepressants show no or insufficient response. In such patients, lithium is often added to the antidepressant for augmentation. The present study investigated the poss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633e35afc455cc7669182cca68e69970
https://doi.org/10.1177/026988110001400207
https://doi.org/10.1177/026988110001400207
Publikováno v:
Human Psychopharmacology: Clinical and Experimental. 13:357-365
To investigate pharmacokinetic parameters, as well as safety of mirtazapine in patients with renal failure, an open-labelled, single oral dose study was performed in normal healthy controls and in patients with mild, moderate and severe renal failure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac09537b24ec55299a079db48726bf94
https://doi.org/10.1002/(sici)1099-1077(199807)13:5<357::aid-hup8>3.0.co
https://doi.org/10.1002/(sici)1099-1077(199807)13:5<357::aid-hup8>3.0.co
Autor:
L. P. C. Delbressine, M. E. G. Moonen, G. Voortman, Peter L. Jacobs, J. E. Paanakker, G. N. Wagenaars, Cees J. Timmer, Frans M. Kaspersen, H.J.M. Van Hal
Publikováno v:
Clinical Drug Investigation. 15:45-55
This paper investigated the pharmacokinetics and biotransformation of mirtazapine in healthy human volunteers. The results showed that the area under the plasma drug concentration-time curve (AUC) of mirtazapine in human plasma appeared to be three t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c2087695935d13762afc345baab8de0
https://doi.org/10.2165/00044011-199815010-00006
https://doi.org/10.2165/00044011-199815010-00006
Publikováno v:
Human Psychopharmacology: Clinical and Experimental. 11:497-509
The effect of gender, age and treatment regimen (single dosing or chronic dosing for 7 days) on the pharmacokinetic profile of mirtazapine was studied in four groups of volunteers. The groups consisted of 9 male adults (25–43 years of age), nine fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b8f2e1dcf2cffeb519039167abc7af4
https://doi.org/10.1002/(sici)1099-1077(199611)11:6<497::aid-hup820>3.0.co
https://doi.org/10.1002/(sici)1099-1077(199611)11:6<497::aid-hup820>3.0.co
Publikováno v:
Human psychopharmacology. 18(2)
Objective To assess the steady-state pharmacokinetics of mirtazapine (30 mg/day orally) and amitriptyline (75 mg/day orally) during combined administration compared with that of either drug administered alone. To evaluate the tolerability and effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c67630174d3e5ae33238e0d25c6fcea5
https://pubmed.ncbi.nlm.nih.gov/12590402
https://pubmed.ncbi.nlm.nih.gov/12590402