A Phase 1, Dose-Ranging Study to Assess Safety and Psychoactive Effects of a Vaporized 5-Methoxy-N, N-Dimethyltryptamine Formulation (GH001) in Healthy Volunteers

Autor: Natasha L. Mason, Theis H. Terwey, Johannes G. Ramaekers, Stefan W. Toennes, J. Reckweg, Cees J Van Leeuwen

Publikováno v: Frontiers in Pharmacology, 12:760671. Frontiers Media S.A.
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology
European Psychiatry, 65, S716-S716. Elsevier France-Éditions Scientifiques et Medicales Elsevier

Introduction 5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT) is a tryptamine with ultra-rapid onset and short duration of psychedelic effects. Prospective studies for other tryptamines have suggested beneficial effects on mental health outcomes. Objecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40abb39de1dc199e77dd4bfdf27fb6c2
https://doi.org/10.3389/fphar.2021.760671

On-the-road driving performance the morning after bedtime administration of lemborexant in healthy adult and elderly volunteers

Autor: Kate Pinner, Carlos Perdomo, Patricia Murphy, Johannes G. Ramaekers, Cees J Van Leeuwen, Margaret Moline, Gleb Filippov, Eric F. P. M. Vuurman, Ishani Landry, Annemiek Vermeeren, Stefan Jongen, Oneeb Majid, Anita C M Van Oers

Publikováno v: Sleep (Online), 42(4):zsy260. Oxford University Press

Study Objectives To assess potential effects of lemborexant on next-morning driving performance in adult and elderly healthy volunteers. Methods Randomized, double-blind, double-dummy, placebo and active-controlled, four period incomplete crossover s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf0b132c1e4d2571e192db3738878466
https://doi.org/10.1093/sleep/zsy260

Residual effects of low-dose sublingual zolpidem on highway driving performance the morning after middle-of-the-night use

Autor: Anita C M Van Oers, Eric F. P. M. Vuurman, Frank Steinberg, Eugene M. Laska, Thomas Roth, Cees J Van Leeuwen, Annemiek Vermeeren, Salvador Rico, Tim R.M. Leufkens

Publikováno v: Sleep, 37(3), 489-496. American Academy of Sleep Medicine

STUDY OBJECTIVE: To evaluate next-morning driving performance after middle-of-the-night use of zolpidem 3.5 mg in a buffered sublingual formulation (ZST). DESIGN: Single-center, four-period, randomized, double-blind, placebo-controlled, crossover stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e048c4a95cdbc614d30ab671665223b0
https://doi.org/10.5665/sleep.3482

Variation in Sensitivity of Aquatic Species to Toxicants: Practical Consequences for Effect Assessment of Chemical Substances

Autor: Cees J. Van Leeuwen, Joop L. M. Hermens, Manon A. Vaal, Janneke A. Hoekstra

Publikováno v: Environmental Management. 25:415-423

/ This study addresses the relation between the sensitivity of aquatic species and mode of action of different classes of organic chemicals. We analyzed large data sets of ecotoxicological information to reveal the interspecies variation in sensitivi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fafaa520829a5afe260cc171ce002ce
https://doi.org/10.1007/s002679910033

Estimating total body residues and baseline toxicity of complex organic mixtures in effluents and surface waters

Autor: Marcel E. Verwoerd, Piet van Duyn, Femke G. Wijnker, Cees J. Van Leeuwen, Willem M. G. M. van Loon, Joop L. M. Hermens, Cees van deGuchte

Publikováno v: Environmental Toxicology and Chemistry. 16:1358-1365

Recently, a new procedure was developed to estimate total body residues (TBRs) in biota after exposure to complex mixtures of organic chemicals in water. The procedure is based on a simulation of bioconcentration using a hydrophobic phase and on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f598eef1e730b948c8ff160018ab2dbb
https://doi.org/10.1002/etc.5620160704