Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Cees A.M. van Ginneken"'
Publikováno v:
Journal of Pharmacy and Pharmacology. 45:614-617
To investigate whether dogs are able to excrete acetylated drugs by active transport, the plasma kinetics and renal excretion of the N4-acetyl metabolites of sulphasomidine and sulphadimethoxine were studied in the beagle dog after a rapid intravenou
Autor:
Cees A.M. van Ginneken, Paul Smits, Y. Tan, Joseph J. M. Van Meyel, Frank W. J. Gribnau, Paul G. G. Gerlag, Frans G. M. Russel
Publikováno v:
Clinical Pharmacokinetics. 22:308-318
To investigate the influence of the presence of oedema on the pharmacokinetics and pharmacodynamics of furosemide (frusemide) we selected 9 hospitalised patients (mean age 70.3 years, range 59 to 84 years) with severe congestive heart failure (NYHA I
Autor:
Bob Th.R. Wentges, A. B. M. Klaassen, Cees A.M. van Ginneken, Yvonne J.B. Van Megen, Jaap F. Rodrigues de Miranda
Publikováno v:
Journal of Allergy and Clinical Immunology. 87:530-540
Nasal hyperreactivity in nasal allergy may be due to changes of the characteristics in adrenergic receptors. Radioligand receptor-binding studies with the antagonists, 3H-prazosin (alpha 1-adrenoceptor), 3H-rauwolscine (alpha 2-adrenoceptor), and 125
Publikováno v:
Pharmacology. 42:287-296
We investigated renal handling and effects of indometacin on renal function in the isolated perfused rat kidney (IPK). Indometacin concentrations less than 2.5 ng/ml did not influence renal function, while higher concentrations caused a decrease in u
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 343:102-107
The effect of substituted benzoates on the transport of p-aminohippurate (PAH) was studied in basolateral (BLMV) and brush border membrane vesicles (BBMV) isolated from dog kidney cortex. For both membranes, kinetic analysis of [3H]PAH transport in t
Publikováno v:
Journal of Pharmacological Methods. 24:89-103
An isolated perfused rat kidney (IPK) preparation is described in which renal perfusion flow, perfusion pressure, urinary flow, urinary pH, and glomerular filtration rate (GFR) are recorded continuously during the perfusion experiment. The usefulness
Autor:
Cees A.M. van Ginneken, Yvonne J.B. Van Megen, Jaap F. Rodrigues de Miranda, Bob Th.R. Wentges, André B. M. Klaassen
Publikováno v:
European Journal of Pharmacology. 182:561-567
The specific binding of [3H]rauwolscine to rat nasal mucosa membranes was saturable, stereoselective and of high affinity. The Scatchard plot pointed to a homogeneous population of binding sites (Kd = 3.6 +/- 0.6 nM; Bmax = 5.1 +/- 0.7 pmol/g). The n
Autor:
Jaap F. Rodrigues de Miranda, Cees A.M. van Ginneken, Yvonne J.B. Van Megen, Bob Th.R. Wentges, Corke J.B.M. Van Ratingen, A. B. M. Klaassen
Publikováno v:
European Journal of Pharmacology. 182:515-525
The specific binding of 125I-(-)-cyanopindolol (125I-(-)-CYP) to homogenates and cryostat sections of rat nasal mucosa was saturable, stereoselective and of high affinity (Kd = 5.0 +/- 0.4 pM. Bmax = 204 +/- 12 fmol/mg protein and Kd = 7.2 +/- 0.7 pM
Publikováno v:
Toxicology Letters. 53:175-177
Autor:
Joseph J.M. Van Meijel, Y. Tan, Frank W. J. Gribnau, Frans G. M. Russel, Cees A.M. van Ginneken
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 496:234-241