Synthesis and molecular modelling studies of pyrimidinones and pyrrolo[3,4-d]-pyrimidinodiones as new antiplasmodial compounds

Autor: Kamilla Rodrigues Rogerio, Leonardo J M Carvalho, Luiza Helena Pinto Domingues, Bruno Junior Neves, José Teófilo Moreira Filho, Rosane Nora Castro, Cesare Bianco Júnior, Claudio Tadeu Daniel-Ribeiro, Carolina Horta Andrade, Cedric Stephan Graebin

Publikováno v: Memorias do Instituto Oswaldo Cruz, Vol 113, Iss 8 (2018)

BACKGROUND Malaria is responsible for 429,000 deaths per year worldwide, and more than 200 million cases were reported in 2015. Increasing parasite resistance has imposed restrictions to the currently available antimalarial drugs. Thus, the search fo

Externí odkaz: https://doaj.org/article/5f961a9c94384129912dea3adadd8440

The Design of Multi-target Drugs to Treat Cardiovascular Diseases: Two (or more) Birds on One Stone

Autor: Lucas Caruso, Nathalia Fonseca Nadur, Marina Brandão da Fonseca, Larissa de Almeida Peixoto Ferreira, Renata Barbosa Lacerda, Cedric Stephan Graebin, Arthur Eugen Kümmerle

Publikováno v: Current Topics in Medicinal Chemistry. 22:366-394

Abstract: Cardiovascular diseases (CVDs) comprise a group of diseases and disorders of the heart and blood vessels, which together are the number one cause of death worldwide, being associated with multiple genetic and modifiable risk factors, and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac3e0fd38ef3cc71a19cd7e3aff83824
https://doi.org/10.2174/1568026622666220201151248

Antiprotozoal agents: How have they changed over a decade?

Autor: Rafael da Rosa, Lílian Sibelle Campos Bernardes, Lara Almida Zimmermann, Arthur Eugen Kümmerle, Kamilla R. Rogério, Vitória de Souza Fernandes, Cedric Stephan Graebin

Publikováno v: Archiv der PharmazieREFERENCES. 355(2)

Neglected tropical diseases are a diverse group of communicable diseases that are endemic in low- or low-to-middle-income countries located in tropical and subtropical zones. The number and availability of drugs for treating these diseases are low, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce2c316e7de5ff168359bb6c04d2b57d
https://pubmed.ncbi.nlm.nih.gov/34661935

The long and winding road of designing phosphodiesterase inhibitors for the treatment of heart failure

Autor: Lucas Caruso, Arthur Eugen Kümmerle, Cedric Stephan Graebin, Nathalia Fonseca Nadur, Luciana Luiz de Azevedo, Renata Barbosa Lacerda

Publikováno v: European journal of medicinal chemistry. 212

Cyclic nucleotide phosphodiesterases (PDEs) are a superfamily of enzymes known to play a critical role in the indirect regulation of several intracellular metabolism pathways through the selective hydrolysis of the phosphodiester bonds of specific se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e825cd8efe9d0cba9209ff7f8913b0e0
https://pubmed.ncbi.nlm.nih.gov/33412421

Synthesis and molecular modelling studies of pyrimidinones and pyrrolo[3,4-d]-pyrimidinodiones as new antiplasmodial compounds

Autor: Cesare Bianco Júnior, José Teófilo Moreira Filho, Cláudio Tadeu Daniel-Ribeiro, Cedric Stephan Graebin, Luiza Helena Pinto Domingues, Kamilla R. Rogério, Carolina Horta Andrade, Leonardo J M Carvalho, Bruno J. Neves, Rosane Nora Castro

Publikováno v: Memórias do Instituto Oswaldo Cruz, Volume: 113, Issue: 8, Article number: e170452, Published: 18 JUN 2018
Memórias do Instituto Oswaldo Cruz., Vol 113, Iss 8 (2018)

BACKGROUND Malaria is responsible for 429,000 deaths per year worldwide, and more than 200 million cases were reported in 2015. Increasing parasite resistance has imposed restrictions to the currently available antimalarial drugs. Thus, the search fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df810219ef66f8045e9a5ab189f0658
https://doi.org/10.1590/0074-02760170452