Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Cedric S. Tremblay"'
Autor:
Cedric S. Tremblay, Sung Kai Chiu, Jesslyn Saw, Hannah McCalmont, Veronique Litalien, Jacqueline Boyle, Stefan E. Sonderegger, Ngoc Chau, Kathryn Evans, Loretta Cerruti, Jessica M. Salmon, Adam McCluskey, Richard B. Lock, Phillip J. Robinson, Stephen M. Jane, David J. Curtis
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
The tumour microenvironment provides signals to support leukaemic stem cells (LSC) maintenance and chemoresistance. Here, the authors show that disrupting niche-associated signalling by inhibiting receptor-mediated endocytosis with a dynamin GTPase i
Externí odkaz:
https://doaj.org/article/9f9ae7f5fae34540a33d8cb9dbda1467
Autor:
Cedric S. Tremblay, Jesslyn Saw, Sung Kai Chiu, Nicholas C. Wong, Kirill Tsyganov, Sarah Ghotb, Alison N. Graham, Feng Yan, Andrew A. Guirguis, Stefan E. Sonderegger, Nicole Lee, Paul Kalitsis, John Reynolds, Stephen B. Ting, David R. Powell, Stephen M. Jane, David J. Curtis
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Cell cycle kinetics of pre-leukemic stem cells (pre-LSCs) may be an important determinant of clonal evolution and therapeutic resistance. Here, the AUs use a transgenic T-ALL mouse model that allows non-dividing cells to be tracked and identify a sub
Externí odkaz:
https://doaj.org/article/b35a3f8af939445d8e61e8a054430aae
Autor:
Steven Goossens, Jueqiong Wang, Cedric S. Tremblay, Jelle De Medts, Sara T’Sas, Thao Nguyen, Jesslyn Saw, Katharina Haigh, David J. Curtis, Pieter Van Vlierberghe, Geert Berx, Tom Taghon, Jody J. Haigh
Publikováno v:
Haematologica, Vol 104, Iss 8 (2019)
ZEB1 and ZEB2 are structurally related E-box binding homeobox transcription factors that induce epithelial to mesenchymal transitions during development and disease. As such, they regulate cancer cell invasion, dissemination and metastasis of solid t
Externí odkaz:
https://doaj.org/article/1410130b35754257a49e5e78840c5270
Attenuated Acceleration to Leukemia after Ezh2 Loss in Nup98-HoxD13 (NHD13) Myelodysplastic Syndrome
Autor:
Victoria Y. Ling, Jesslyn Saw, Cedric S. Tremblay, Stefan E. Sonderegger, Emma Toulmin, Jacqueline Boyle, Sung Kai Chiu, Steven W. Lane, Stephen B. Ting, David J. Curtis
Publikováno v:
HemaSphere, Vol 3, Iss 4 (2019)
Externí odkaz:
https://doaj.org/article/a3b4749fb5ac4d3c8316268378a28849
Autor:
Cedric S. Tremblay, Jesslyn Saw, Jacqueline A Boyle, Katharina Haigh, Veronique Litalien, Hannah Ruth McCalmont, Kathryn Evans, Richard B Lock, Stephen M Jane, Jody J Haigh, David J Curtis
Publikováno v:
Blood.
IL-7 supports the growth and chemoresistance of T-cell acute lymphoblastic leukemia (T-ALL), particularly the early T-cell precursor subtype (ETP-ALL), which frequently has activating mutations of IL-7 signaling. STAT5 is an attractive therapeutic ta
Autor:
Sining Ye, Paschalis Theotokis, Jae Young Lee, Min Joung Kim, Danica Nheu, Olivia Ellen, Thomas Bedford, Padmanabhan Ramanujam, David K Wright, Stuart J McDonald, Amani Alrehaili, Maha Bakhuraysah, Jung Hee Kang, Christopher Siatskas, Cedric S Tremblay, David J Curtis, Nikolaos Grigoriadis, Mastura Monif, Stephen M Strittmatter, Steven Petratos
Publikováno v:
Brain Communications. 5
Nogo receptor 1 is the high affinity receptor for the potent myelin-associated inhibitory factors that make up part of the inflammatory extracellular milieu during experimental autoimmune encephalomyelitis. Signalling through the Nogo receptor 1 comp
Autor:
Cedric S. Tremblay, Sung Kai Chiu, Jesslyn Saw, Hannah McCalmont, Veronique Litalien, Jacqueline Boyle, Stefan E. Sonderegger, Ngoc Chau, Kathryn Evans, Loretta Cerruti, Jessica M. Salmon, Adam McCluskey, Richard B. Lock, Phillip J. Robinson, Stephen M. Jane, David J. Curtis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-21688-1
Externí odkaz:
https://doaj.org/article/9846dc9e5dfd409a8bf2b3f5a56fc30d
Autor:
James E Vince, Carmel Patricia Daunt, Anissa Jabbour, Sheila Dias, Cedric S. Tremblay, Karla C. Fischer
Publikováno v:
Cell Death and Disease, Vol 12, Iss 1, Pp 1-16 (2021)
Cell Death & Disease
Cell Death & Disease
The IκB kinase complex, consisting of IKK1, IKK2 and the regulatory subunit NEMO, is required for NF-κB signalling following the activation of several cell surface receptors, such as members of the Tumour Necrosis Factor Receptor superfamily and th
Publikováno v:
Experimental hematology. 104
Endocytosis entails selective packaging of cell surface cargos in cytoplasmic vesicles, thereby controlling key intrinsic cellular processes as well as the response of normal and malignant cells to their microenvironment. The purpose of this review i
Autor:
Bastien Gerby, Cedric S Tremblay, Mathieu Tremblay, Shanti Rojas-Sutterlin, Sabine Herblot, Josée Hébert, Guy Sauvageau, Sébastien Lemieux, Eric Lécuyer, Diogo F T Veiga, Trang Hoang
Publikováno v:
PLoS Genetics, Vol 10, Iss 12, p e1004768 (2014)
The molecular determinants that render specific populations of normal cells susceptible to oncogenic reprogramming into self-renewing cancer stem cells are poorly understood. Here, we exploit T-cell acute lymphoblastic leukemia (T-ALL) as a model to
Externí odkaz:
https://doaj.org/article/b02922aa59b74cc7982008ea73a621e7