Zobrazeno 1 - 10
of 476
pro vyhledávání: '"Cedric S, Raine"'
Autor:
Gerald Ponath, Matthew R. Lincoln, Maya Levine-Ritterman, Calvin Park, Somiah Dahlawi, Mayyan Mubarak, Tomokazu Sumida, Laura Airas, Shun Zhang, Cigdem Isitan, Thanh D. Nguyen, Cedric S. Raine, David A. Hafler, David Pitt
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
It is unclear if multiple sclerosis (MS) genetic susceptibility can be mediated through perturbations of CNS-intrinsic pathways. Authors show that the rs7665090 risk variant is associated with astrocyte responses that enhance lymphocyte recruitment,
Externí odkaz:
https://doaj.org/article/34975c90ae204b8282c217e372c0f104
Autor:
Benjamin M Laitman, Linnéa Asp, John N Mariani, Jingya Zhang, Jia Liu, Setsu Sawai, Candice Chapouly, Sam Horng, Elisabeth G Kramer, Nesanet Mitiku, Hannah Loo, Natalie Burlant, Xiomara Pedre, Yuko Hara, German Nudelman, Elena Zaslavsky, Young-Min Lee, David A Braun, Q Richard Lu, Goutham Narla, Cedric S Raine, Scott L Friedman, Patrizia Casaccia, Gareth R John
Publikováno v:
PLoS Biology, Vol 14, Iss 5, p e1002467 (2016)
Growth factors of the gp130 family promote oligodendrocyte differentiation, and viability, and myelination, but their mechanisms of action are incompletely understood. Here, we show that these effects are coordinated, in part, by the transcriptional
Externí odkaz:
https://doaj.org/article/2dfa39249e6546189fb8f3c3d17cf445
Autor:
Kathleen N. O'Guin, Ross C. Gruber, Cedric S. Raine, Hillary M. Guzik, Bradford K. Poulos, Bridget Shafit-Zagardo
Publikováno v:
ASN Neuro, Vol 6 (2014)
The molecular requirements for human myelination are incompletely defined, and further study is needed to fully understand the cellular mechanisms involved during development and in demyelinating diseases. We have established a human co-culture model
Externí odkaz:
https://doaj.org/article/cfe3aa81fb124be99247edcc0fd2c1f9
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15748 (2010)
Growth arrest-specific protein 6 (gas6) activities are mediated through the Tyro3, Axl, and Mer family of receptor tyrosine kinases. Gas6 is expressed and secreted by a wide variety of cell types, including cells of the central nervous system (CNS).
Externí odkaz:
https://doaj.org/article/5f2629f246524b4aa40da9fca47778d5
Publikováno v:
Neurology® Neuroimmunology & Neuroinflammation
article-version (Version of Record) 3
article-version (Version of Record) 3
Background and ObjectivesTo investigate the total circular RNA (circRNA) profile in patients with relapsing-remitting multiple sclerosis (RRMS) and healthy controls (HCs).MethodsHybridization microarray was used to define the circRNA profile in perip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b53bbc2daac5d49fe9fea7930c1d304b
https://doi.org/10.1212/nxi.0000000000001041
https://doi.org/10.1212/nxi.0000000000001041
Autor:
Geoffrey S. Perumal, Cedric S. Raine, Maria Gulinello, Lauren Kozakiewicz, Julie E. Williamson, Ross C. Gruber, Bridget Shafit-Zagardo, Hillary Guzik, Juwen C. DuBois, Alex K. Ray
Publikováno v:
Glia. 65:2051-2069
The TAM (Tyro3, Axl, and MerTK) family of receptor tyrosine kinases (RTKs) and their ligands, Gas6 and ProS1, are important for innate immune responses and central nervous system (CNS) homeostasis. While only Gas6 directly activates Axl, ProS1 activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e7deda2ab74e91935ef0dd908891351
https://doi.org/10.1002/glia.23214
https://doi.org/10.1002/glia.23214
Publikováno v:
Journal of Neuroscience Research. 95:1984-1992
A lot of available data on lipid immunology in multiple sclerosis (MS) have been derived from studies using synthetic lipids, therefore the role of lipids in the immunopathogenesis of MS remains poorly defined. The present study on the lipid response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4894080b2af2c375fad431811de09550
https://doi.org/10.1002/jnr.24062
https://doi.org/10.1002/jnr.24062
Publikováno v:
Multiple Sclerosis Journal. 24:449-458
Background: Exosomes are small extracellular vesicles that provide cell-to-cell communication and are involved in immunoregulation. Objective: To investigate serum exosomes for the presence of myelin proteins outside the central nervous system (CNS)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699ad208e9065698c7ae7d4fd5d097bb
https://doi.org/10.1177/1352458517696597
https://doi.org/10.1177/1352458517696597
Autor:
F. Rezan Sahinkaya, Alexander O. Vortmeyer, Cedric S. Raine, William J. Housley, Sriram Ramanan, David Pitt, Seunghoon Lee, Gerald Ponath, Mayyan Mubarak
Publikováno v:
Brain. 140:399-413
Astrocytes are key players in the pathology of multiple sclerosis and can assume beneficial and detrimental roles during lesion development. The triggers and timing of the different astroglial responses in acute lesions remain unclear. Astrocytes in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c083618b03de5be27185be4c91b483
https://doi.org/10.1093/brain/aww298
https://doi.org/10.1093/brain/aww298
Autor:
Mayyan Mubarak, David A. Hafler, Maya Levine-Ritterman, Cigdem Isitan, Shun Zhang, Somiah Dahlawi, Cedric S. Raine, David Pitt, Matthew R Lincoln, Thanh D. Nguyen, Laura Airas, Calvin Park, Gerald Ponath, Tomokazu Sumida
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Epigenetic annotation studies of genetic risk variants for multiple sclerosis (MS) implicate dysfunctional lymphocytes in MS susceptibility; however, the role of central nervous system (CNS) cells remains unclear. We investigated the effect of the ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8327521937486ef81a706ffe0df26ec2
http://europepmc.org/articles/PMC6297228
http://europepmc.org/articles/PMC6297228