Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Cedric Neveu"'
Autor:
Alistair Antonopoulos, Stephen R. Doyle, David J. Bartley, Alison A. Morrison, Ray Kaplan, Sue Howell, Cedric Neveu, Valentina Busin, Eileen Devaney, Roz Laing
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 20, Iss , Pp 17-26 (2022)
Haemonchus contortus is a haematophagous parasitic nematode that infects small ruminants and causes significant animal health concerns and economic losses within the livestock industry on a global scale. Treatment primarily depends on broad-spectrum
Externí odkaz:
https://doaj.org/article/5b7a894a47184051b2f051ca941faf01
Autor:
Patricia G Izquierdo, Claude L Charvet, Cedric Neveu, A Christopher Green, John E H Tattersall, Lindy Holden-Dye, Vincent O'Connor
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0284786 (2023)
Organophosphate intoxication via acetylcholinesterase inhibition executes neurotoxicity via hyper stimulation of acetylcholine receptors. Here, we use the organophosphate paraoxon-ethyl to treat C. elegans and use its impact on pharyngeal pumping as
Externí odkaz:
https://doaj.org/article/4f9d60c94fb44e47b32f26d841109694
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 3, Pp 540-549 (2018)
The control of parasitic nematodes impacting animal health relies on the use of broad spectrum anthelmintics. However, intensive use of these drugs has led to the selection of resistant parasites in livestock industry. In that respect, there is curre
Externí odkaz:
https://doaj.org/article/8facfffc3fb247c7b21ce8ca60bbdcd8
Autor:
Alexander P. Gerhard, Jürgen Krücken, Cedric Neveu, Claude L. Charvet, Abdallah Harmache, Georg von Samson-Himmelstjerna
Publikováno v:
Pharmaceuticals, Vol 14, Iss 2, p 153 (2021)
Macrocyclic lactones (MLs) are widely used drugs to treat and prevent parasitic nematode infections. In many nematode species including a major pathogen of foals, Parascaris univalens, resistance against MLs is widespread, but the underlying resistan
Externí odkaz:
https://doaj.org/article/54c8b8d5ec3e4a2ba662fd6b5d088de4
Autor:
Alexandra Blanchard, Fabrice Guégnard, Claude L Charvet, Anna Crisford, Elise Courtot, Christine Sauvé, Abdallah Harmache, Thomas Duguet, Vincent O'Connor, Philippe Castagnone-Sereno, Barbara Reaves, Adrian J Wolstenholme, Robin N Beech, Lindy Holden-Dye, Cedric Neveu
Publikováno v:
PLoS Pathogens, Vol 14, Iss 5, p e1006996 (2018)
Cholinergic agonists such as levamisole and pyrantel are widely used as anthelmintics to treat parasitic nematode infestations. These drugs elicit spastic paralysis by activating acetylcholine receptors (AChRs) expressed in nematode body wall muscles
Externí odkaz:
https://doaj.org/article/28410ae1fb11412eb1de52ffddf3d9f6
Autor:
Andrew C. Kotze, Peter W. Hunt, Philip Skuce, Georg von Samson-Himmelstjerna, Richard J. Martin, Heinz Sager, Jürgen Krücken, Jane Hodgkinson, Anne Lespine, Aaron R. Jex, John S. Gilleard, Robin N. Beech, Adrian J. Wolstenholme, Janina Demeler, Alan P. Robertson, Claude L. Charvet, Cedric Neveu, Ronald Kaminsky, Lucien Rufener, Melanie Alberich, Cecile Menez, Roger K. Prichard
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 4, Iss 3, Pp 164-184 (2014)
Anthelmintic resistance has a great impact on livestock production systems worldwide, is an emerging concern in companion animal medicine, and represents a threat to our ongoing ability to control human soil-transmitted helminths. The Consortium for
Externí odkaz:
https://doaj.org/article/0a884c7c4a7c454ea5b5be5fc9a7abce
Autor:
Thomas B Duguet, Claude L Charvet, Sean G Forrester, Claudia M Wever, Joseph A Dent, Cedric Neveu, Robin N Beech
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 7, p e0004826 (2016)
Helminth parasites rely on fast-synaptic transmission in their neuromusculature to experience the outside world and respond to it. Acetylcholine plays a pivotal role in this and its receptors are targeted by a wide variety of both natural and synthet
Externí odkaz:
https://doaj.org/article/371b1798dcb24cd888a2df12fb70ba77
Autor:
Elise Courtot, Claude L Charvet, Robin N Beech, Abdallah Harmache, Adrian J Wolstenholme, Lindy Holden-Dye, Vincent O'Connor, Nicolas Peineau, Debra J Woods, Cedric Neveu
Publikováno v:
PLoS Pathogens, Vol 11, Iss 12, p e1005267 (2015)
Acetylcholine receptors are pentameric ligand-gated channels involved in excitatory neuro-transmission in both vertebrates and invertebrates. In nematodes, they represent major targets for cholinergic agonist or antagonist anthelmintic drugs. Despite
Externí odkaz:
https://doaj.org/article/0e442599256b407ca8e198036851e625
Autor:
Samuel K Buxton, Claude L Charvet, Cedric Neveu, Jacques Cabaret, Jacques Cortet, Nicolas Peineau, Melanie Abongwa, Elise Courtot, Alan P Robertson, Richard J Martin
Publikováno v:
PLoS Pathogens, Vol 10, Iss 1, p e1003870 (2014)
Nicotinic acetylcholine receptors (nAChRs) of parasitic nematodes are required for body movement and are targets of important "classical" anthelmintics like levamisole and pyrantel, as well as "novel" anthelmintics like tribendimidine and derquantel.
Externí odkaz:
https://doaj.org/article/be0879b4a8b04c91a8eaccf07faabcc7
Autor:
Mohamed Issouf, Fabrice Guégnard, Christine Koch, Yves Le Vern, Alexandra Blanchard-Letort, Hua Che, Robin N Beech, Dominique Kerboeuf, Cedric Neveu
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87802 (2014)
Eosinophils are one of the major mammalian effector cells encountered by helminths during infection. In the present study, we investigated the effects of eosinophil granule exposure on the sheep parasitic nematode Haemonchus contortus as a model. H.
Externí odkaz:
https://doaj.org/article/8b9a6b59c96e4279ba57e3d577d41a54