Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Cedric Govaerts"'
Autor:
Maud Sigoillot, Marie Overtus, Magdalena Grodecka, Daniel Scholl, Abel Garcia-Pino, Toon Laeremans, Lihua He, Els Pardon, Ellen Hildebrandt, Ina Urbatsch, Jan Steyaert, John R. Riordan, Cedric Govaerts
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
The leading cause of cystic fibrosis is the deletion of phenylalanine 508 (F508del) in the first nucleotide-binding domain (NBD1) of the cystic fibrosis transmembrane conductance regulator (CFTR). Here authors we develop nanobodies targeting NBD1 of
Externí odkaz:
https://doaj.org/article/2a36a5cc137946bdbc014d5d58e302cb
Autor:
Marijke Brams, Cedric Govaerts, Kumiko Kambara, Kerry L Price, Radovan Spurny, Anant Gharpure, Els Pardon, Genevieve L Evans, Daniel Bertrand, Sarah CR Lummis, Ryan E Hibbs, Jan Steyaert, Chris Ulens
Publikováno v:
eLife, Vol 9 (2020)
Pentameric ligand-gated ion channels (pLGICs) or Cys-loop receptors are involved in fast synaptic signaling in the nervous system. Allosteric modulators bind to sites that are remote from the neurotransmitter binding site, but modify coupling of liga
Externí odkaz:
https://doaj.org/article/342cb67467c141c1a4b0ebacf9821115
Autor:
Anastassia Troupiotis-Tsaïlaki, Julian Zachmann, Inés González-Gil, Angel Gonzalez, Silvia Ortega-Gutiérrez, Maria L. López-Rodríguez, Leonardo Pardo, Cedric Govaerts
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Sphingosine-1-phosphate (S1P) is a lipid mediator that can activate five cell membrane G protein-coupled receptors (GPCRs) which carry a variety of essential functions and are promising drug targets. S1P is composed of a polar zwitterionic h
Externí odkaz:
https://doaj.org/article/a21d0cf6f7474819a25877758a9730b9
Autor:
Stefano Benvegnù, Diego Franciotta, Josh Sussman, Angela Bachi, Elisabetta Zardini, Paola Torreri, Cedric Govaerts, Salvatore Pizzo, Giuseppe Legname
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e5968 (2009)
Doppel protein (Dpl) is a paralog of the cellular form of the prion protein (PrP(C)), together sharing common structural and biochemical properties. Unlike PrP(C), which is abundantly expressed throughout the central nervous system (CNS), Dpl protein
Externí odkaz:
https://doaj.org/article/e482f724883a4a0ab534dde518bc9244
Autor:
Stefano Benvegnù, Diego Franciotta, Josh Sussman, Angela Bachi, Elisabetta Zardini, Paola Torreri, Cedric Govaerts, Salvatore Pizzo, Giuseppe Legname
Publikováno v:
PLoS ONE, Vol 4, Iss 8 (2009)
Externí odkaz:
https://doaj.org/article/b33c489f72d3405b91656c095c61778c
Autor:
Marijke, Brams, Cedric, Govaerts, Kumiko, Kambara, Kerry L, Price, Radovan, Spurny, Anant, Gharpure, Els, Pardon, Genevieve L, Evans, Daniel, Bertrand, Sarah Cr, Lummis, Ryan E, Hibbs, Jan, Steyaert, Chris, Ulens
Publikováno v:
eLife
Pentameric ligand-gated ion channels (pLGICs) or Cys-loop receptors are involved in fast synaptic signaling in the nervous system. Allosteric modulators bind to sites that are remote from the neurotransmitter binding site, but modify coupling of liga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6c3ed64939ed2946da544d5f4b660af5
https://pubmed.ncbi.nlm.nih.gov/31990273
https://pubmed.ncbi.nlm.nih.gov/31990273
Autor:
Robert Seed, Tyren Barker, Kate J. McKnelly, Jane Connor, Paul J. Wolters, Shunsuke Minagawa, Stephanie Cambier, Hideya Kitamura, Arthur C. Hill, Jun Araya, David J. Erle, Ronald Herbst, Louis F. Reichardt, Royce Ma, Mitsuo Hashimoto, David M. Jablons, Amanda Goodsell, Haruhiko Yanagisawa, Jody L. Baron, Weihua Wen, Nishimura Stephen, Shenping Wu, Ping Tsui, Cedric Govaerts, Lynne Murray, Oliver J. Brand, Andrea J. Barczak, Ran Cheng, Yifan Cheng, Anthony Cormier, Jianlong Lou, James D. Marks
Airway remodeling, caused by inflammation and fibrosis, is a major component of chronic obstructive pulmonary disease (COPD) and currently has no effective treatment. Transforming growth factor–β (TGF-β) has been widely implicated in the pathogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4518c3206e3acf2dcd5f5ab7d498e3fa
https://europepmc.org/articles/PMC4341974/
https://europepmc.org/articles/PMC4341974/
Publikováno v:
Biophysical Journal. 100(3)
A classical strategy to understand lipid-protein interactions is to assay structure and function of purified membrane proteins reconstituted in proteoliposomes whose lipid composition, fluidity, membrane tension, and/or curvature can be controlled. B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f5e033610655f44e560293c92cdfb9c
Autor:
Xavier Deupi, Leonardo Pardo, Cedric Govaerts, Lei Shi, Juan A. Ballesteros, Jonathan A. Javitch
Publikováno v:
Contemporary Clinical Neuroscience ISBN: 9781588293657
Genome sequencing projects have identified the G protein-coupled receptor (GPCR) superfamily as one of the largest classes of proteins in mammalian genomes (1). For example, preliminary analyses of the human genome have revealed up to 600 GPCRs (2,3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::741a1ad9b73bb139fc35ee6760159ddd
https://doi.org/10.1007/978-1-59259-919-6_17
https://doi.org/10.1007/978-1-59259-919-6_17
Autor:
Eneko, Urizar, Sylvie, Claeysen, Xavier, Deupí, Cedric, Govaerts, Sabine, Costagliola, Gilbert, Vassart, Leonardo, Pardo
Publikováno v:
The Journal of biological chemistry. 280(17)
We aimed at understanding molecular events involved in the activation of a member of the G protein-coupled receptor family, the thyrotropin receptor. We have focused on the transmembrane region and in particular on a network of polar interactions bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d299a8acb08361241ac064fed895a575
https://pubmed.ncbi.nlm.nih.gov/15722344
https://pubmed.ncbi.nlm.nih.gov/15722344