TSLP Expression: Analysis with a ZsGreen TSLP Reporter Mouse

Autor: Joy A. Williams, Mark C. Udey, Stephen F. Porcella, Xi Chen, William E. Paul, Ilkka S. Junttila, Cedric Dewas, Jay T. Linton, Daniel E. Sturdevant, Tetsuya Honda, Lionel Feigenbaum, Lily Koo

Publikováno v: The Journal of Immunology. 194:1372-1380

Thymic stromal lymphopoietin (TSLP) is a type I cytokine that plays a central role in induction of allergic inflammatory responses. Its principal targets have been reported to be dendritic cells and/or CD4 T cells; epithelial cells are a principal so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f52b6f60db1b784204bfa261071b2e
https://doi.org/10.4049/jimmunol.1400519

TNF-α Induces Phosphorylation of p47phox in Human Neutrophils: Partial Phosphorylation of p47phox Is a Common Event of Priming of Human Neutrophils by TNF-α and Granulocyte-Macrophage Colony-Stimulating Factor

Autor: Marie-Anne Gougerot-Pocidalo, Pham My-Chan Dang, Cedric Dewas, Jamel El-Benna

Publikováno v: The Journal of Immunology. 171:4392-4398

Phosphorylation of p47phox is a key event in NADPH oxidase activation. We examined the ability of proinflammatory cytokines such as TNFα, IL-1, and G-CSF to induce this process compared with GM-CSF. Only TNF-α and GM-CSF induced a clear p47phox pho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c4f3570311ad004efdd2bda3c8697d
https://doi.org/10.4049/jimmunol.171.8.4392

A specific p47phox - serine phosphorylated by convergent MAPKs mediates neutrophil NADPH oxidase priming at inflammatory sites

Autor: Gilles Hayem, Marie Anne Gougerot-Pocidalo, Jamel El-Benna, Ole N. Jensen, Tarek Boussetta, Houssam Raad, Allan Stensballe, Pham My-Chan Dang, Yolande Kroviarski, Cedric Dewas

Publikováno v: Dang, P M-C, Stensballe, A, Boussetta, T, Raad, H, Dewas, C, Kroviarski, Y, Hayem, G, Jensen, O N, Gougerot-Pocidalo, M A & El-Benna, J 2006, ' A specific p47phox-serine phosphorylated by convergent MAPKs mediates neutrophil NADPH oxidase priming at inflammatory sites ', Journal of Medical Investigation, vol. 116, pp. 2033-2043 . https://doi.org/10.1172/JCI27544
Dang, P M-C, Stensballe, A, Boussetta, T, Raad, H, Kroviarski, Y, Dewas, C, Hayem, G, Jensen, O N, Gougerot-Pocidalo, M-A & El-Benna, J 2006, ' A specific p47phox-serine phosphorylated by convergent MAPKs mediates neutrophil NADPH oxidase priming at inflammatory sites. ', Journal of Clinical Investigation, vol. 116, no. 7, pp. 2033-2043 .
Aalborg University

Neutrophil NADPH oxidase plays a key role in host defense and in inflammation by releasing large amounts of superoxide and other ROSs. Proinflammatory cytokines such as GM-CSF and TNF-alpha prime ROS production by neutrophils through unknown mechanis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7cac0a1f15f75a56ee8ad0a78129928
https://portal.findresearcher.sdu.dk/da/publications/cf595f20-d847-11db-ae98-000ea68e967b

P40phox associates with the neutrophil Triton X-100-insoluble cytoskeletal fraction and PMA-activated membrane skeleton: a comparative study with P67phox and P47phox

Autor: O Cachia, Michèle Fay, Jacques Hakim, Pham My-Chan Dang, Françoise Morel, Sabrina Vergnaud, Marie-Anne Gougerot-Pocidalo, Sylvie Chollet-Martin, Cedric Dewas, Valérie Andrieu, J. El Benna

Publikováno v: Journal of leukocyte biology. 66(6)

NADPH oxidase is an O-generating enzyme found in phagocytes such as neutrophils. It is composed of a membrane-bound cytochrome b, the cytosolic proteins p67phox, p47phox, p40phox, and the G-protein p21rac. The system is dormant in resting cells but a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec316c90634a85b17e8756c5627e7e5e
https://pubmed.ncbi.nlm.nih.gov/10614785