Výsledky vyhledávání - "Cedric, Gaggioli"

Akademický článek

Mechanical forces rewire metabolism in the tumor niche

Publikováno v: Molecular & Cellular Oncology, Vol 6, Iss 3 (2019)

Tumor niche extracellular matrix stiffening and tumor cell metabolic reprogramming are two fundamental mediators of tumor progression. We recently elucidated a mechanistic interconnection between mechanotransduction and tumor metabolic rewiring in ca

Externí odkaz: https://doaj.org/article/b63b67f6ddd64dfab48dd9abf4c58baf

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Supplementary table S2 from Matrix Stiffening and EGFR Cooperate to Promote the Collective Invasion of Cancer Cells

Autor: Cedric Gaggioli, Dmitry V. Bulavin, Christophe Duranton, Guerrino Meneguzzi, Paul Hofman, Marius Ilie, Alexander Emelyanov, Caroline Bailleux, Majdi Maiel, Margaux Lecacheur, Sabrina Pisano, Isabelle Bourget, Jonas Friard, Alexandre Bozec, Thomas Bertero, Eloise M. Grasset

Quantification of organotypic invasion assay screening.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::317a242c1a04e5ca0231498eb95e73fd
https://doi.org/10.1158/0008-5472.22420398.v1

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Supplemental materials and methods from Matrix Stiffening and EGFR Cooperate to Promote the Collective Invasion of Cancer Cells

Supplemental files

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::496440c4409e564e5a8acaee016cc8e6
https://doi.org/10.1158/0008-5472.22420407

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Supplementary figures and legends from Matrix Stiffening and EGFR Cooperate to Promote the Collective Invasion of Cancer Cells

Supplemental data

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e977bef04a16f87f90cfce514cbcdf34
https://doi.org/10.1158/0008-5472.22420404

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Data from Matrix Stiffening and EGFR Cooperate to Promote the Collective Invasion of Cancer Cells

In squamous cell carcinoma (SCC), tissue invasion by collectively invading cells requires physical forces applied by tumor cells on their surrounding extracellular matrix (ECM). Cancer-related ECM is composed of thick collagen bundles organized by ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b1f2e9e1d4ed06a149eeef1db3007d
https://doi.org/10.1158/0008-5472.c.6510639.v1

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Akademický článek

LIF Mediates Proinvasive Activation of Stromal Fibroblasts in Cancer

Autor: Jean Albrengues, Isabelle Bourget, Catherine Pons, Vincent Butet, Paul Hofman, Sophie Tartare-Deckert, Chloe C. Feral, Guerrino Meneguzzi, Cedric Gaggioli

Publikováno v: Cell Reports, Vol 7, Iss 5, Pp 1664-1678 (2014)

Signaling crosstalk between tumor cells and fibroblasts confers proinvasive properties to the tumor microenvironment. Here, we identify leukemia inhibitory factor (LIF) as a tumor promoter that mediates proinvasive activation of stromal fibroblasts i

Externí odkaz: https://doaj.org/article/02b44a85929d4f6c96a6cd29aa10b865

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Pathogenic NR2F1 variants cause a developmental ocular phenotype recapitulated in a mutant mouse model

Publikováno v: Brain Communications

Pathogenic NR2F1 variants cause a rare autosomal dominant neurodevelopmental disorder referred to as the Bosch–Boonstra–Schaaf Optic Atrophy Syndrome. Although visual loss is a prominent feature seen in affected individuals, the molecular and cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b90fedfdb6514e3afbf5ab682f5c7373
https://doi.org/10.1093/braincomms/fcab162

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A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma

Autor: Aude Mallavialle, Sébastien Schaub, Marcel Deckert, Virginie Prod'homme, Christophe Girard, Frédéric Larbret, Stéphane Audebert, Rania Ben Jouira, Margaux Lecacheur, Bernard Mari, Berestjuk I, Serena Diazzi, Maeva Gesson, Jean-Christophe Marine, Sophie Tartare-Deckert, Sabrina Pisano, Eleonora Leucci, Cedric Gaggioli

Publikováno v: Cancer Research
Cancer Research, American Association for Cancer Research, 2020, 80 (10), pp.1927-1941. ⟨10.1158/0008-5472.CAN-19-2914⟩
Cancer Research, 2020, 80 (10), pp.1927-1941. ⟨10.1158/0008-5472.CAN-19-2914⟩

Aberrant extracellular matrix (ECM) deposition and stiffening is a physical hallmark of several solid cancers and is associated with therapy failure. BRAF-mutant melanomas treated with BRAF and MEK inhibitors almost invariably develop resistance that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a027cd246efa824743a6249caf782519
https://hal.archives-ouvertes.fr/hal-02912547

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Targeting DDR1 and DDR2 overcomes matrix-mediated melanoma cell adaptation to BRAF-targeted therapy

Autor: Frédéric Larbret, Stéphane Audebert, Cedric Gaggioli, Berestjuk I, Marcel Deckert, Serena Diazzi, Sophie Tartare-Deckert, Aude Mallavialle, Prod’homme, Christophe Girard, Sabrina Pisano, Rovera C, Thierry Passeron, Margaux Lecacheur

Resistance to BRAF and MEK inhibitors in BRAFV600E mutant melanomas remains a major obstacle that limits patient benefit. Microenvironment components including the extracellular matrix (ECM) can support tumor cell adaptation and tolerance to targeted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bede5ceff1922f35b406991a943c87f9

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Mechanical forces rewire metabolism in the tumor niche

Autor: Cedric Gaggioli, Thomas Bertero

Publikováno v: Molecular & Cellular Oncology
Molecular & Cellular Oncology, Taylor et Francis, 2019, 6 (3), pp.1592945. ⟨10.1080/23723556.2019.1592945⟩

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8957d916708d10242b0b194a6776063
https://europepmc.org/articles/PMC6512933/

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