Identification of fragments targeting SMYD3 using highly sensitive kinetic and multiplexed biosensor-based screening.

Autor: FitzGerald EA; Department of Chemistry - BMC, Uppsala University Uppsala Sweden helena.danielson@kemi.uu.se.; Beactica Therapeutics Virdings allé 2 Uppsala Sweden., Cederfelt D; Department of Chemistry - BMC, Uppsala University Uppsala Sweden helena.danielson@kemi.uu.se., Lund BA; Department of Chemistry - BMC, Uppsala University Uppsala Sweden helena.danielson@kemi.uu.se.; Department of Chemistry, UiT The Arctic University of Norway Tromsø Norway., Myers NEM; Department of Chemistry - BMC, Uppsala University Uppsala Sweden helena.danielson@kemi.uu.se.; Beactica Therapeutics Virdings allé 2 Uppsala Sweden., Zhang H; Department of Chemistry - BMC, Uppsala University Uppsala Sweden helena.danielson@kemi.uu.se., Dobritzsch D; Department of Chemistry - BMC, Uppsala University Uppsala Sweden helena.danielson@kemi.uu.se., Danielson UH; Department of Chemistry - BMC, Uppsala University Uppsala Sweden helena.danielson@kemi.uu.se.; Science for Life Laboratory, Uppsala University Uppsala Sweden.

Publikováno v: RSC medicinal chemistry [RSC Med Chem] 2024 Mar 20; Vol. 15 (6), pp. 1982-1990. Date of Electronic Publication: 2024 Mar 20 (Print Publication: 2024).

Discovery of the 4-aminopiperidine-based compound EM127 for the site-specific covalent inhibition of SMYD3.

Autor: Parenti MD; Institute of Organic Synthesis and Photoreactivity - National Research Council, 40129, Bologna, Italy., Naldi M; Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Bologna, Italy; Centre for Applied Biomedical Research, Alma Mater Studiorum University of Bologna, Bologna, Italy., Manoni E; Institute of Organic Synthesis and Photoreactivity - National Research Council, 40129, Bologna, Italy., Fabini E; Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Bologna, Italy., Cederfelt D; Department of Chemistry - BMC, Uppsala University, 751 23, Uppsala, Sweden., Talibov VO; Department of Chemistry - BMC, Uppsala University, 751 23, Uppsala, Sweden; BioMAX beam line, MAX IV Laboratory, 22484, Lund, Sweden., Gressani V; Department of Biosciences, University of Milan, 20133, Milan, Italy., Guven U; Department of Biosciences, University of Milan, 20133, Milan, Italy., Grossi V; Medical Genetics National Institute for Gastroenterology, IRCCS 'S. de Bellis' Research Hospital, Castellana Grotte, Italy., Fasano C; Medical Genetics National Institute for Gastroenterology, IRCCS 'S. de Bellis' Research Hospital, Castellana Grotte, Italy., Sanese P; Medical Genetics National Institute for Gastroenterology, IRCCS 'S. de Bellis' Research Hospital, Castellana Grotte, Italy., De Marco K; Medical Genetics National Institute for Gastroenterology, IRCCS 'S. de Bellis' Research Hospital, Castellana Grotte, Italy., Shtil AA; Department of Chemistry, Lomonosov Moscow State University, Moscow, 119991, Russia; Blokhin National Medical Research Center of Oncology, Moscow, 115478, Russia., Kurkin AV; Department of Chemistry, Lomonosov Moscow State University, Moscow, 119991, Russia., Altieri A; Department of Chemistry, Lomonosov Moscow State University, Moscow, 119991, Russia; EDASA Scientific Srls, 66050, San Salvo (CH), Italy., Danielson UH; Department of Chemistry - BMC, Uppsala University, 751 23, Uppsala, Sweden; Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Caretti G; Department of Biosciences, University of Milan, 20133, Milan, Italy., Simone C; Medical Genetics National Institute for Gastroenterology, IRCCS 'S. de Bellis' Research Hospital, Castellana Grotte, Italy; Medical Genetics, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari Aldo Moro, Bari, 70124, Italy., Varchi G; Institute of Organic Synthesis and Photoreactivity - National Research Council, 40129, Bologna, Italy., Bartolini M; Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Bologna, Italy. Electronic address: manuela.bartolini3@unibo.it., Del Rio A; Institute of Organic Synthesis and Photoreactivity - National Research Council, 40129, Bologna, Italy; Innovamol Consulting Srl, Via San Faustino 167, 41126, Modena, Italy. Electronic address: alberto.delrio@gmail.com.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2022 Dec 05; Vol. 243, pp. 114683. Date of Electronic Publication: 2022 Sep 08.

Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor.

Autor: FitzGerald EA; Department of Chemistry - BMC, Uppsala University Uppsala 751 23 Sweden helena.danielson@kemi.uu.se.; Beactica Therapeutics Virdings allé 2 Uppsala 754 40 Sweden., Butko MT; Biodesy, Inc. 170 Harbor Way South San Francisco 94080 CA USA., Boronat P; Amsterdam Institute of Molecular and Life Sciences (AIMMS), Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam De Boelelaan 1108 1081 HZ Amsterdam The Netherlands., Cederfelt D; Department of Chemistry - BMC, Uppsala University Uppsala 751 23 Sweden helena.danielson@kemi.uu.se., Abramsson M; Department of Chemistry - BMC, Uppsala University Uppsala 751 23 Sweden helena.danielson@kemi.uu.se., Ludviksdottir H; Department of Chemistry - BMC, Uppsala University Uppsala 751 23 Sweden helena.danielson@kemi.uu.se., van Muijlwijk-Koezen JE; Amsterdam Institute of Molecular and Life Sciences (AIMMS), Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam De Boelelaan 1108 1081 HZ Amsterdam The Netherlands., de Esch IJP; Amsterdam Institute of Molecular and Life Sciences (AIMMS), Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam De Boelelaan 1108 1081 HZ Amsterdam The Netherlands., Dobritzsch D; Department of Chemistry - BMC, Uppsala University Uppsala 751 23 Sweden helena.danielson@kemi.uu.se., Young T; Biodesy, Inc. 170 Harbor Way South San Francisco 94080 CA USA., Danielson UH; Department of Chemistry - BMC, Uppsala University Uppsala 751 23 Sweden helena.danielson@kemi.uu.se.; Science for Life Laboratory, Uppsala University Sweden.

Publikováno v: RSC advances [RSC Adv] 2021 Feb 17; Vol. 11 (13), pp. 7527-7537. Date of Electronic Publication: 2021 Feb 17 (Print Publication: 2021).

Recent Advances in Surface Plasmon Resonance (SPR) Technology for Detecting Ovarian Cancer Biomarkers.

Autor: Kumar, Vikneswary Ravi¹ (AUTHOR) drchewkt@gmail.com, Kampan, Nirmala Chandralega¹ (AUTHOR) nirmala@ppukm.ukm.edu.my, Abd Aziz, Nor Haslinda¹ (AUTHOR), Teik, Chew Kah¹ (AUTHOR), Shafiee, Mohamad Nasir¹ (AUTHOR), Menon, P. Susthitha² (AUTHOR) nirmala@ppukm.ukm.edu.my

Publikováno v: Cancers. Dec2023, Vol. 15 Issue 23, p5607. 26p.

SMYD3 Modulates the HGF/MET Signaling Pathway in Gastric Cancer.

Autor: De Marco, Katia¹ (AUTHOR) katia.demarco@irccsdebellis.it, Lepore Signorile, Martina¹ (AUTHOR) martina.lepore@irccsdebellis.it, Di Nicola, Elisabetta¹ (AUTHOR) elisabetta.dinicola@irccsdebellis.it, Sanese, Paola¹ (AUTHOR) paola.sanese@irccsdebellis.it, Fasano, Candida¹ (AUTHOR) candida.fasano@irccsdebellis.it, Forte, Giovanna¹ (AUTHOR) giovanna.forte@irccsdebellis.it, Disciglio, Vittoria¹ (AUTHOR) vittoria.disciglio@irccsdebellis.it, Pantaleo, Antonino¹ (AUTHOR) antonino.pantaleo@irccsdebellis.it, Varchi, Greta² (AUTHOR) greta.varchi@isof.cnr.it, Del Rio, Alberto^2,3 (AUTHOR) alberto.delrio@isof.cnr.it, Grossi, Valentina¹ (AUTHOR) valentina.grossi@irccsdebellis.it, Simone, Cristiano^1,4 (AUTHOR) valentina.grossi@irccsdebellis.it

Publikováno v: Cells (2073-4409). Oct2023, Vol. 12 Issue 20, p2481. 15p.