Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide.

Autor: Le TDV; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, United States., Liu D; Department of Medicine, Vanderbilt University Medical Center, Nashville, United States., Besing GK; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, United States., Raghavan R; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, United States., Ellis BJ; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, United States., Ceddia RP; Department of Medicine, Vanderbilt University Medical Center, Nashville, United States., Collins S; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, United States.; Department of Medicine, Vanderbilt University Medical Center, Nashville, United States., Ayala JE; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, United States.

Publikováno v: ELife [Elife] 2023 Nov 06; Vol. 12. Date of Electronic Publication: 2023 Nov 06.

Discovery of another mechanism for the inhibition of particulate guanylyl cyclases by the natriuretic peptide clearance receptor.

Autor: Liu D; Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville TN 37232., Ceddia RP; Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville TN 37232., Zhang W; Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville TN 37232., Shi F; Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville TN 37232., Fang H; Integrative Metabolism Program, Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL 32827., Collins S; Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville TN 37232.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Jul 11; Vol. 120 (28), pp. e2307882120. Date of Electronic Publication: 2023 Jul 03.

Increased Energy Expenditure and Protection From Diet-Induced Obesity in Mice Lacking the cGMP-Specific Phosphodiesterase PDE9.

Autor: Ceddia RP; Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.; Integrative Metabolism Program, Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, FL., Liu D; Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.; Integrative Metabolism Program, Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, FL., Shi F; Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.; Integrative Metabolism Program, Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, FL., Crowder MK; Department of Pharmacology, Vanderbilt University, Nashville, TN., Mishra S; Division of Cardiology, Department of Medicine, Johns Hopkins University and School of Medicine, Baltimore, MD., Kass DA; Division of Cardiology, Department of Medicine, Johns Hopkins University and School of Medicine, Baltimore, MD.; Department of Biomedical Engineering, Johns Hopkins University and School of Medicine, Baltimore, MD.; Department of Pharmacology and Molecular Sciences, Johns Hopkins University and School of Medicine, Baltimore, MD., Collins S; Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN sheila.collins@vumc.org.; Integrative Metabolism Program, Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, FL.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN.

Publikováno v: Diabetes [Diabetes] 2021 Dec; Vol. 70 (12), pp. 2823-2836. Date of Electronic Publication: 2021 Oct 07.

Manipulation of Dietary Amino Acids Prevents and Reverses Obesity in Mice Through Multiple Mechanisms That Modulate Energy Homeostasis.

Autor: Ruocco C; Center for Study and Research on Obesity, Department of Biomedical Technology and Translational Medicine, University of Milan, Milan, Italy., Ragni M; Center for Study and Research on Obesity, Department of Biomedical Technology and Translational Medicine, University of Milan, Milan, Italy., Rossi F; Center for Study and Research on Obesity, Department of Biomedical Technology and Translational Medicine, University of Milan, Milan, Italy., Carullo P; IRCCS Humanitas Clinical and Research Center, Rozzano, Italy.; Institute of Genetic and Biomedical Research, National Research Council, Rozzano, Italy., Ghini V; Interuniversity Consortium for Magnetic Resonance, Sesto Fiorentino, Italy., Piscitelli F; Institute of Biomolecular Chemistry, National Research Council, Pozzuoli, Italy., Cutignano A; Institute of Biomolecular Chemistry, National Research Council, Pozzuoli, Italy., Manzo E; Institute of Biomolecular Chemistry, National Research Council, Pozzuoli, Italy., Ioris RM; Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland.; Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland., Bontems F; Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland.; Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland., Tedesco L; Center for Study and Research on Obesity, Department of Biomedical Technology and Translational Medicine, University of Milan, Milan, Italy., Greco CM; IRCCS Humanitas Clinical and Research Center, Rozzano, Italy., Pino A; Department of Diagnostics and Public Health, University of Verona, Verona, Italy., Severi I; Department of Experimental and Clinical Medicine, Marche Polytechnic University, Center of Obesity, Ancona, Italy., Liu D; Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., Ceddia RP; Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., Ponzoni L; Center for Study and Research on Obesity, Department of Biomedical Technology and Translational Medicine, University of Milan, Milan, Italy.; Institute of Neuroscience, National Research Council, Milan, Italy., Tenori L; FiorGen Foundation, Sesto Fiorentino, Italy.; Center of Magnetic Resonance, University of Florence, Sesto Fiorentino, Italy., Rizzetto L; Department of Food Quality and Nutrition, Research and Innovation Center, Edmund Mach Foundation, San Michele all'Adige, Italy., Scholz M; Department of Food Quality and Nutrition, Research and Innovation Center, Edmund Mach Foundation, San Michele all'Adige, Italy., Tuohy K; Department of Food Quality and Nutrition, Research and Innovation Center, Edmund Mach Foundation, San Michele all'Adige, Italy., Bifari F; Laboratory of Cell Metabolism and Regenerative Medicine, Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy., Di Marzo V; Canada Excellence Research Chair Microbiome-Endocannabinoidome Axis in Metabolic Health, Université Laval, Quebec City, Canada.; Joint International Research Unit for Chemical and Biochemical Research on the Microbiome and Its Impact on Metabolic Health and Nutrition, Institute of Biomolecular Chemistry, National Research Council, Pozzuoli, Italy and Université Laval, Quebec City, Canada., Luchinat C; Interuniversity Consortium for Magnetic Resonance, Sesto Fiorentino, Italy.; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy., Carruba MO; Center for Study and Research on Obesity, Department of Biomedical Technology and Translational Medicine, University of Milan, Milan, Italy., Cinti S; Department of Experimental and Clinical Medicine, Marche Polytechnic University, Center of Obesity, Ancona, Italy., Decimo I; Department of Diagnostics and Public Health, University of Verona, Verona, Italy., Condorelli G; IRCCS Humanitas Clinical and Research Center, Rozzano, Italy.; Institute of Genetic and Biomedical Research, National Research Council, Rozzano, Italy.; Humanitas University, Rozzano, Italy., Coppari R; Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland.; Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland., Collins S; Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., Valerio A; Department of Molecular and Translational Medicine, Brescia University, Brescia, Italy., Nisoli E; Center for Study and Research on Obesity, Department of Biomedical Technology and Translational Medicine, University of Milan, Milan, Italy enzo.nisoli@unimi.it.

Publikováno v: Diabetes [Diabetes] 2020 Nov; Vol. 69 (11), pp. 2324-2339. Date of Electronic Publication: 2020 Aug 10.

The effect of the EP3 antagonist DG-041 on male mice with diet-induced obesity.

Autor: Ceddia RP; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Downey JD; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Morrison RD; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Kraemer MP; Department of Biochemistry, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Davis SE; Department of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Wu J; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Lindsley CW; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Department of Chemistry, Vanderbilt University, Nashville, TN 37232, USA., Yin H; Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Daniels JS; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Breyer RM; Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA; Department of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Biochemistry, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address: rich.breyer@vumc.org.

Publikováno v: Prostaglandins & other lipid mediators [Prostaglandins Other Lipid Mediat] 2019 Oct; Vol. 144, pp. 106353. Date of Electronic Publication: 2019 Jul 02.