Effects of multi-medication treatments including cardiovascular drugs in male and female APPNL-G-F knock in mice

Autor: Francesca Eroli, Christina Tsagkogianni, Stefania Zerial, Felix Andersson, Zeynep Acararicin, Maria Latorre-Leal, Jonas Wastesson, Angel Cedazo-Minguez, Kristina Johnell, Silvia Maioli

Publikováno v: Cerebral Circulation - Cognition and Behavior, Vol 6, Iss , Pp 100309- (2024)

Objectives: Cardiovascular conditions like hypercholesterolemia and hypertension increase the risk for Alzheimer's Disease (AD). Thus, certain AD risk profiles may benefit from optimized multi- medication therapies including for example cholesterol-l

Externí odkaz: https://doaj.org/article/3a924c5836b3426ea6ee9dea1e64fe98

Impaired astrocytic synaptic function by peripheral cholesterol metabolite 27-hydroxycholesterol.

Autor: Spanos, Fokion, Gerenu, Gorka, Goikolea, Julen, Latorre-Leal, María, Balleza-Tapia, Hugo, Gomez, Karen, Álvarez-Jiménez, Laura, Piras, Antonio, Gómez-Galán, Marta, Fisahn, André, Cedazo-Minguez, Angel, Maioli, Silvia, Loera-Valencia, Raúl

Publikováno v: Frontiers in Cellular Neuroscience; 2024, p1-13, 13p

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High levels of 27-hydroxycholesterol results in synaptic plasticity alterations in the hippocampus

Autor: Raul Loera-Valencia, Erika Vazquez-Juarez, Alberto Muñoz, Gorka Gerenu, Marta Gómez-Galán, Maria Lindskog, Javier DeFelipe, Angel Cedazo-Minguez, Paula Merino-Serrais

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Abstract Alterations in brain cholesterol homeostasis in midlife are correlated with a higher risk of developing Alzheimer’s disease (AD). However, global cholesterol-lowering therapies have yielded mixed results when it comes to slowing down or pr

Externí odkaz: https://doaj.org/article/0b049b45ec844c18afc7850c0fa00835

27-hydroxycholesterol promotes oligodendrocyte maturation: Implications for hypercholesterolemia-associated brain white matter changes.

Autor: Alanko V; Division of Clinical Geriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden.; Division of Neurogeriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden., Gaminde-Blasco A; Department of Neuroscience, University of Basque Country (UPV/EHU) and CIBERNED, Leioa, Spain.; Achucarro Basque Center for Neuroscience, Leioa, Spain., Quintela-López T; Department of Neuroscience, University of Basque Country (UPV/EHU) and CIBERNED, Leioa, Spain.; Achucarro Basque Center for Neuroscience, Leioa, Spain., Loera-Valencia R; Division of Neurogeriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden., Solomon A; Division of Clinical Geriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden.; Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland.; Ageing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College London, London, UK., Björkhem I; Department of Laboratory Medicine, Karolinska University Hospital, Huddinge, Sweden., Cedazo-Minguez A; Division of Neurogeriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden., Maioli S; Division of Neurogeriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden., Tabacaru G; Division of Neurogeriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden., Latorre-Leal M; Division of Neurogeriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden., Matute C; Department of Neuroscience, University of Basque Country (UPV/EHU) and CIBERNED, Leioa, Spain.; Achucarro Basque Center for Neuroscience, Leioa, Spain., Kivipelto M; Division of Clinical Geriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden.; Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland.; Ageing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College London, London, UK.; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland., Alberdi E; Department of Neuroscience, University of Basque Country (UPV/EHU) and CIBERNED, Leioa, Spain.; Achucarro Basque Center for Neuroscience, Leioa, Spain., Sandebring-Matton A; Division of Clinical Geriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden.; Division of Neurogeriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden.; Ageing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College London, London, UK.

Publikováno v: Glia [Glia] 2023 Jun; Vol. 71 (6), pp. 1414-1428. Date of Electronic Publication: 2023 Feb 13.