Platelet Inhibition Prevents NLRP3 Inflammasome Activation and Sepsis-Induced Kidney Injury

Autor: Chelsea Giachelli, Cedar H. Baik, Olivia K. Travis, Geilda A. Tardo, Marivee Borges-Rodriguez, Corbin A. Shields, Denise C. Cornelius, Jan M. Williams, Robert W. Tramel

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10330, p 10330 (2021)

Platelets, cellular mediators of thrombosis, are activated during sepsis and are increasingly recognized as mediators of the immune response. Platelet activation is significantly increased in sepsis patients compared to ICU control patients. Despite

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce658e4d680512d793b4abd889115d7a
https://pubmed.ncbi.nlm.nih.gov/34638670

Interleukin-17 signaling mediates cytolytic natural killer cell activation in response to placental ischemia

Autor: Cassandra Stubbs, Jan M. Williams, Olivia K. Travis, Mallory Greer, James Lemon, Dakota White, Chelsea Giachelli, Willie L. Thompson, Denise C. Cornelius, Cedar H. Baik

Publikováno v: Am J Physiol Regul Integr Comp Physiol

T-helper (TH)17s, IL-17, and cytolytic natural killer cells (cNKs) are increased in preeclampsia and contribute to the hypertension, inflammation, and fetal growth restriction that occurs in response to placental ischemia in the reduced uterine perfu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca3cbeb42e75d37997fdf3f6b8d49b69
https://pubmed.ncbi.nlm.nih.gov/32320265

Abstract 017: Cytolytic Natural Killer Cells Play a Direct Role in Causing Hypertension and Intrauterine Growth Restriction in Pregnant Rats

Autor: Jan M. Williams, Cedar H. Baik, Chelsea Giachelli, Carmilya Jackson, Denise C. Cornelius, Olivia K. Travis

Publikováno v: Hypertension. 74

The R educed U terine P erfusion P ressure (RUPP) rat model of placental ischemia mirrors many of the hallmark features of preeclampsia (PE) such as hypertension, intrauterine growth restriction (IUGR), and immune activation, which includes increased

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a7ddcabb750523124258d110bee31a4
https://doi.org/10.1161/hyp.74.suppl_1.017

NLRP3 inflammasome activation in platelets in response to sepsis

Autor: Corbin A. Shields, Denise C. Cornelius, Cassandra M. Young, W. Austin Pierce, Cedar H. Baik, Jan M. Williams, Bibek Poudel, Dakota White, Olivia K. Travis

Publikováno v: Physiological Reports

Sepsis is a complex syndrome characterized by organ dysfunction and a dysregulated immune host response to infection. There is currently no effective treatment for sepsis, but platelets have been proposed as a potential therapeutic target for the tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adcd4e856dcc6509e2084f67a6f09bb8
http://europepmc.org/articles/PMC6499866

NLRP3 inflammasome inhibition attenuates sepsis-induced platelet activation and prevents multi-organ injury in cecal-ligation puncture

Autor: Geilda A. Tardo, Jan M. Williams, Olivia K. Travis, Mallory Greer, Robert W. Tramel, Denise C. Cornelius, Marivee Borges-Rodriguez, Chelsea Giachelli, Cedar H. Baik

Publikováno v: PLoS ONE
PLoS ONE, Vol 15, Iss 6, p e0234039 (2020)

Sepsis is characterized by organ dysfunction due to a dysregulated immune response to infection. Currently, no effective treatment for sepsis exists. Platelets are recognized as mediators of the immune response and may be a potential therapeutic targ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf5f82dba799cc8ec293141f50920fd7
https://doi.org/10.1371/journal.pone.0234039