Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Cecilio Lopez-Galíndez"'
Autor:
Silvia Pérez-Yanes, María Pernas, Silvia Marfil, Romina Cabrera-Rodríguez, Raquel Ortiz, Víctor Urrea, Carla Rovirosa, Judith Estévez-Herrera, Isabel Olivares, Concepción Casado, Cecilio Lopez-Galindez, Julià Blanco, Agustín Valenzuela-Fernández
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
The understanding of HIV-1 pathogenesis and clinical progression is incomplete due to the variable contribution of host, immune, and viral factors. The involvement of viral factors has been investigated in extreme clinical phenotypes from rapid progr
Externí odkaz:
https://doaj.org/article/5e4739c8580d48f4a215263e47f633ee
Autor:
Concepción Casado, Sara Marrero-Hernández, Daniel Márquez-Arce, María Pernas, Sílvia Marfil, Ferran Borràs-Grañana, Isabel Olivares, Romina Cabrera-Rodríguez, María-Soledad Valera, Laura de Armas-Rillo, Philippe Lemey, Julià Blanco, Agustín Valenzuela-Fernández, Cecilio Lopez-Galíndez
Publikováno v:
mBio, Vol 9, Iss 2 (2018)
ABSTRACT A small group of HIV-1-infected individuals, called long-term nonprogressors (LTNPs), and in particular a subgroup of LTNPs, elite controllers (LTNP-ECs), display permanent control of viral replication and lack of clinical progression. This
Externí odkaz:
https://doaj.org/article/b9c065f676794e36920b4671b9e28c10
Autor:
Ana Moyano, Oscar Blanch-Lombarte, Laura Tarancon-Diez, Nuria Pedreño-Lopez, Miguel Arenas, Tamara Alvaro, Concepción Casado, Isabel Olivares, Mar Vera, Carmen Rodriguez, Jorge del Romero, Cecilio López-Galíndez, Ezequiel Ruiz-Mateos, Julia G. Prado, María Pernas
Publikováno v:
Retrovirology, Vol 19, Iss 1, Pp 1-14 (2022)
Abstract Background Long-Term Non-Progressors (LTNPs) are untreated Human Immunodeficiency virus type 1 (HIV-1) infected individuals able to control disease progression for prolonged periods. However, the LTNPs status is temporary, as viral load incr
Externí odkaz:
https://doaj.org/article/9781fb5c03ed4e0cb8b67f8ba4137e88
Autor:
Concepcion Casado, Cristina Galvez, Maria Pernas, Laura Tarancon-Diez, Carmen Rodriguez, Víctor Sanchez-Merino, Mar Vera, Isabel Olivares, Rebeca De Pablo-Bernal, Alberto Merino-Mansilla, Jorge Del Romero, Ramon Lorenzo-Redondo, Ezequiel Ruiz-Mateos, María Salgado, Javier Martinez-Picado, Cecilio Lopez-Galindez
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Abstract Elite controllers (EC) represent a small subset of HIV-1-infected people that spontaneously control viral replication. However, natural virological suppression and absence of immune dysfunction are not always long-term sustained. We define e
Externí odkaz:
https://doaj.org/article/9afa80bdaabf490c8c3d29884df46882
Autor:
Soledad Delgado, Celia Perales, Carlos García-Crespo, María Eugenia Soria, Isabel Gallego, Ana Isabel de Ávila, Brenda Martínez-González, Lucía Vázquez-Sirvent, Cecilio López-Galíndez, Federico Morán, Esteban Domingo
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 3 (2021)
ABSTRACT RNA viruses replicate as complex mutant spectra termed viral quasispecies. The frequency of each individual genome in a mutant spectrum depends on its rate of generation and its relative fitness in the replicating population ensemble. The ad
Externí odkaz:
https://doaj.org/article/041d5980a232449789212264732757dd
Autor:
Agustín Valenzuela-Fernández, Romina Cabrera-Rodríguez, Concha Casado, Silvia Pérez-Yanes, María Pernas, Jonay García-Luis, Silvia Marfil, Isabel Olivares, Judith Estévez-Herrera, Rodrigo Trujillo-González, Julià Blanco, Cecilio Lopez-Galindez
Publikováno v:
Biomedicines, Vol 10, Iss 9, p 2172 (2022)
In the absence of antiviral therapy, HIV-1 infection progresses to a wide spectrum of clinical manifestations that are the result of an entangled contribution of host, immune and viral factors. The contribution of these factors is not completely esta
Externí odkaz:
https://doaj.org/article/6a1c4b76e28a4bbd8416d44bc7ae05e9
Autor:
Brenda Martínez-González, María Eugenia Soria, Lucía Vázquez-Sirvent, Cristina Ferrer-Orta, Rebeca Lobo-Vega, Pablo Mínguez, Lorena de la Fuente, Carlos Llorens, Beatriz Soriano, Ricardo Ramos-Ruíz, Marta Cortón, Rosario López-Rodríguez, Carlos García-Crespo, Pilar Somovilla, Antoni Durán-Pastor, Isabel Gallego, Ana Isabel de Ávila, Soledad Delgado, Federico Morán, Cecilio López-Galíndez, Jordi Gómez, Luis Enjuanes, Llanos Salar-Vidal, Mario Esteban-Muñoz, Jaime Esteban, Ricardo Fernández-Roblas, Ignacio Gadea, Carmen Ayuso, Javier Ruíz-Hornillos, Nuria Verdaguer, Esteban Domingo, Celia Perales
Publikováno v:
Pathogens, Vol 11, Iss 6, p 662 (2022)
Populations of RNA viruses are composed of complex and dynamic mixtures of variant genomes that are termed mutant spectra or mutant clouds. This applies also to SARS-CoV-2, and mutations that are detected at low frequency in an infected individual ca
Externí odkaz:
https://doaj.org/article/1a2a6aef651b4189a3f7cf754f253bd4
Autor:
Maria Pernas, Victor Sanchez-Merino, Concepcion Casado, Alberto Merino-Mansilla, Isabel Olivares, Eloisa Yuste, Cecilio Lopez-Galindez
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134054 (2015)
This study evaluated the neutralization breadth in dually infected (DI) HIV-1 long-term non-progressor elite controller patients (LTNP-EC) using a representative minipanel of 6 viruses from 5 different subtypes. Our results showed an improved neutral
Externí odkaz:
https://doaj.org/article/d1f80ba92c3d40068c0f79d5859df3a1
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88579 (2014)
Human Immunodeficiency Virus type 1 (HIV-1) because of high mutation rates, large population sizes, and rapid replication, exhibits complex evolutionary strategies. For the analysis of evolutionary processes, the graphical representation of fitness l
Externí odkaz:
https://doaj.org/article/6a2ed8afb4a841e8b4de71a78d165cf0
Autor:
István Bartha, Jonathan M Carlson, Chanson J Brumme, Paul J McLaren, Zabrina L Brumme, Mina John, David W Haas, Javier Martinez-Picado, Judith Dalmau, Cecilio López-Galíndez, Concepción Casado, Andri Rauch, Huldrych F Günthard, Enos Bernasconi, Pietro Vernazza, Thomas Klimkait, Sabine Yerly, Stephen J O’Brien, Jennifer Listgarten, Nico Pfeifer, Christoph Lippert, Nicolo Fusi, Zoltán Kutalik, Todd M Allen, Viktor Müller, P Richard Harrigan, David Heckerman, Amalio Telenti, Jacques Fellay, for the HIV Genome-to-Genome Study and the Swiss HIV Cohort Study
Publikováno v:
eLife, Vol 2 (2013)
HIV-1 sequence diversity is affected by selection pressures arising from host genomic factors. Using paired human and viral data from 1071 individuals, we ran >3000 genome-wide scans, testing for associations between host DNA polymorphisms, HIV-1 seq
Externí odkaz:
https://doaj.org/article/5d773a28930442e492f392ab859e9ef9