Ofatumumab Modulates Inflammatory T Cell Responses and Migratory Potential in Patients With Multiple Sclerosis

Autor: Marina Rode von Essen, Rikke Holm Hansen, Camilla Højgaard, Cecilie Ammitzbøll, Heinz Wiendl, Finn Sellebjerg

Publikováno v: von Essen, M R, Hansen, R H, Højgaard, C, Ammitzbøll, C, Wiendl, H & Sellebjerg, F 2022, ' Ofatumumab Modulates Inflammatory T Cell Responses and Migratory Potential in Patients With Multiple Sclerosis ', Neurology(R) neuroimmunology & neuroinflammation, vol. 9, no. 4, e200004 . https://doi.org/10.1212/NXI.0000000000200004

Background and ObjectivesThe anti-CD20 antibody ofatumumab is an efficacious therapy for multiple sclerosis (MS) through depletion of B cells. The purpose of this study was to examine the derivative effects of B cell depletion on the peripheral immun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73525e2200477c98e26a8f66cb38aa61
https://pubmed.ncbi.nlm.nih.gov/35672145

GPR15+ T cells are Th17 like, increased in smokers and associated with multiple sclerosis

Autor: Oskar McWilliam, Helle Bach Søndergaard, Marina Rode von Essen, Finn Sellebjerg, Annette Bang Oturai, Eva Rosa Petersen, Lars Börnsen, Cecilie Ammitzbøll, Rikke Ratzer, Jeppe Romme Christensen

Publikováno v: Journal of Autoimmunity. 97:114-121

Smoking is a risk factor for the development and progression of multiple sclerosis (MS); however, the pathogenic effects of smoking are poorly understood. We studied the smoking-associated chemokine receptor-like molecule GPR15 in relation to relapsi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08ccab71b404d57d1082d81a62767651
https://doi.org/10.1016/j.jaut.2018.09.005

Natalizumab differentially affects plasmablasts and B cells in multiple sclerosis

Autor: Oskar McWilliam, Marina Rode von Essen, Finn Sellebjerg, Cecilie Ammitzbøll, Jeppe Romme Christensen, Alexander Cuculiza Henriksen, Eva Rosa Petersen

Publikováno v: Multiple sclerosis and related disorders. 52

Natalizumab treatment increases the frequencies of B cells in blood but reduces IgG in blood and CSF. Plasmablasts are important in the production of IgG, and the development of plasmablasts is CD49d dependent.We hypothesized that natalizumab treatme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c7c9f6bcf73adccbe16cda79e6a8a30
https://pubmed.ncbi.nlm.nih.gov/33984651

Biomarkers of systemic inflammation, soluble IL-2Rα and the multiple sclerosis-associated IL2RA SNP rs2104286 in healthy subjects and multiple sclerosis patients

Autor: Mie Reith Mahler, Annette Bang Oturai, Lars Börnsen, Cecilie Ammitzbøll, Stefan Cobanovic, Finn Sellebjerg, Helle Bach Søndergaard, Sophie Buhelt

Publikováno v: Multiple Sclerosis and Related Disorders. 54:103140

Soluble interleukin-2 (IL-2) receptor α (sIL-2Rα) antagonizes IL-2 signaling and is involved in the pathogenesis of several immune-mediated diseases including multiple sclerosis (MS). The level of sIL-2Rα is affected by the MS-associated single nu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd25242939f1b3c7b43800b0750c51f
https://doi.org/10.1016/j.msard.2021.103140

MAIT cell subtypes in multiple sclerosis

Autor: Finn Sellebjerg, Marina Rode von Essen, Rikke Holm Hansen, Helene Højsgaard Chow, Cecilie Ammitzbøll, Oskar McWilliam

Publikováno v: Journal of Neuroimmunology. 339:577117

In patients with multiple sclerosis (MS) and healthy controls (HC) we studied circulating MAIT cells and MAIT cell subtypes expressing CXCR3 and CCR6 by flow cytometry. Absolute numbers of MAIT cells and specifically Tc17-like MAIT cells were lower i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6582abb2b3c3aeb27b319f10655b17a
https://doi.org/10.1016/j.jneuroim.2019.577117