Zobrazeno 1 - 10
of 261
pro vyhledávání: '"Cecilia W. Lo"'
Autor:
Kira Mascho, Svetlana A. Yatsenko, Cecilia W. Lo, Xinxiu Xu, Jennifer Johnson, Lindsey R. Helvaty, Stephanie Burns Wechsler, Chaya N. Murali, Seema R. Lalani, Vidu Garg, Jennelle C. Hodge, Kim L. McBride, Stephanie M. Ware, Jiuann-Huey Ivy Lin
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Introduction5p deletion syndrome, also called Cri-du-chat syndrome 5p is a rare genetic syndrome with reports up to 36% of patients are associated with congenital heart defects. We investigated the association between left outflow tract obstruction a
Externí odkaz:
https://doaj.org/article/2ea28b86dde34d79982956d3247450a9
Autor:
Elizabeth R. Rochon, Jianmin Xue, Manush Sayd Mohammed, Caroline Smith, Anders Hay-Schmidt, Anthony W. DeMartino, Adam Clark, Qinzi Xu, Cecilia W. Lo, Michael Tsang, Jesus Tejero, Mark T. Gladwin, Paola Corti
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Cytoglobin is a heme protein with unresolved physiological function. Genetic deletion of zebrafish cytoglobin (cygb2) causes developmental defects in left-right cardiac determination, which in humans is associated with defects in ciliary fun
Externí odkaz:
https://doaj.org/article/de386078cb7a499faa7a141ecbc586bf
Autor:
Richard J B Francis, Jovenal T San Agustin, Heather L Szabo Rogers, Cheng Cui, Julie A Jonassen, Thibaut Eguether, John A Follit, Cecilia W Lo, Gregory J Pazour
Publikováno v:
PLoS Biology, Vol 21, Iss 12, p e3002425 (2023)
Ciliopathies are associated with wide spectrum of structural birth defects (SBDs), indicating important roles for cilia in development. Here, we provide novel insights into the temporospatial requirement for cilia in SBDs arising from deficiency in I
Externí odkaz:
https://doaj.org/article/38fef819639546269aa5ba0887cfbda5
Autor:
Benjamin J. Landis, Lindsey R. Helvaty, Gabrielle C. Geddes, Jiuann‐Huey Ivy Lin, Svetlana A. Yatsenko, Cecilia W. Lo, William L. Border, Stephanie Burns Wechsler, Chaya N. Murali, Mahshid S. Azamian, Seema R. Lalani, Robert B. Hinton, Vidu Garg, Kim L. McBride, Jennelle C. Hodge, Stephanie M. Ware
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 18 (2023)
Background Chromosomal microarray analysis (CMA) provides an opportunity to understand genetic causes of congenital heart disease (CHD). The methods for describing cardiac phenotypes in patients with CMA abnormalities have been inconsistent, which ma
Externí odkaz:
https://doaj.org/article/3ce4e66e20b2416085e8144a51318ce2
Autor:
Ricardo A. DeMoya, Rachel E. Forman-Rubinsky, Deon Fontaine, Joseph Shin, Simon C. Watkins, Cecilia W. Lo, Michael Tsang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Hypoplastic left heart syndrome (HLHS) is a congenital heart disease where the left ventricle is reduced in size. A forward genetic screen in mice identified SIN3A associated protein 130 kDa (Sap130), part of the chromatin modifying SIN3A/HDAC comple
Externí odkaz:
https://doaj.org/article/1e0da7b8f313498dbc762e7aba202c98
Autor:
George C. Gabriel, William A. Devine, Bethany K. Redel, Kristin M. Whitworth, Melissa Samuel, Lee D. Spate, Raissa F. Cecil, Randall S. Prather, Yijen L. Wu, Kevin D. Wells, Cecilia W. Lo
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract The pig is an ideal model system for studying human development and disease due to its similarities to human anatomy, physiology, size, and genome. Further, advances in CRISPR gene editing have made genetically engineered pigs viable models
Externí odkaz:
https://doaj.org/article/93f422a95d7043129581d1f40224dc7b
Autor:
Zeineb Bakey, Oscar A Cabrera, Julia Hoefele, Dinu Antony, Kaman Wu, Michael W Stuck, Dimitra Micha, Thibaut Eguether, Abigail O Smith, Nicole N van der Wel, Matias Wagner, Lara Strittmatter, Philip L Beales, Julie A Jonassen, Isabelle Thiffault, Maxime Cadieux-Dion, Laura Boyes, Saba Sharif, Beyhan Tüysüz, Desiree Dunstheimer, Hans W M Niessen, William Devine, Cecilia W Lo, Hannah M Mitchison, Miriam Schmidts, Gregory J Pazour
Publikováno v:
PLoS Genetics, Vol 19, Iss 6, p e1010796 (2023)
Motile and non-motile cilia play critical roles in mammalian development and health. These organelles are composed of a 1000 or more unique proteins, but their assembly depends entirely on proteins synthesized in the cell body and transported into th
Externí odkaz:
https://doaj.org/article/e3c33751139d4a74a9903b2f1e069797
Autor:
Jodie K. Votava-Smith, Jenna Gaesser, Anna Lonyai Harbison, Vince Lee, Nhu Tran, Vidya Rajagopalan, Sylvia del Castillo, S. Ram Kumar, Elizabeth Herrup, Tracy Baust, Jennifer A. Johnson, George C. Gabriel, William T. Reynolds, Julia Wallace, Benjamin Meyers, Rafael Ceschin, Cecilia W. Lo, Vanessa J. Schmithorst, Ashok Panigrahy
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
ObjectiveTerm congenital heart disease (CHD) neonates display abnormalities of brain structure and maturation, which are possibly related to underlying patient factors, abnormal physiology and perioperative insults. Our primary goal was to delineate
Externí odkaz:
https://doaj.org/article/7b940e0985d74517948688f5516069fd
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Respiratory mucociliary clearance (MCC) is a key defense mechanism that functions to entrap and transport inhaled pollutants, particulates, and pathogens away from the lungs. Previous work has identified a number of anesthetics to have cilia
Externí odkaz:
https://doaj.org/article/9cb1cb17294a4c8f9374e89f293fce45
Autor:
Daryaneh Badaly, Sue R. Beers, Rafael Ceschin, Vincent K. Lee, Shahida Sulaiman, Alexandria Zahner, Julia Wallace, Aurélia Berdaa-Sahel, Cheryl Burns, Cecilia W. Lo, Ashok Panigrahy
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
ObjectiveChildren, adolescents, and young adults with congenital heart defects (CHD) often display executive dysfunction. We consider the prefrontal and cerebellar brain structures as mechanisms for executive dysfunction among those with CHD.Methods5
Externí odkaz:
https://doaj.org/article/0f7496d2e3c844899b16920152b6beeb