Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Cecilia Tubert"'
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S459-S460 (2023)
Externí odkaz:
https://doaj.org/article/0e99a37b71b541c7a2c2786cd168860e
Publikováno v:
Neurobiology of Disease, Vol 128, Iss , Pp 3-8 (2019)
In the last decade, scientific and clinical interest in the pedunculopontine nucleus (PPN) has grown dramatically. This growth is largely a consequence of experimental work demonstrating its connection to the control of gait and of clinical work impl
Externí odkaz:
https://doaj.org/article/249396c5ad78477dae5802dd8ed45844
Autor:
Cecilia Tubert, Irene R.E. Taravini, Eden Flores-Barrera, Gonzalo M. Sánchez, María Alejandra Prost, María Elena Avale, Kuei Y. Tseng, Lorena Rela, Mario Gustavo Murer
Publikováno v:
Cell Reports, Vol 16, Iss 10, Pp 2749-2762 (2016)
The mechanism underlying a hypercholinergic state in Parkinson’s disease (PD) remains uncertain. Here, we show that disruption of the Kv1 channel-mediated function causes hyperexcitability of striatal cholinergic interneurons in a mouse model of PD
Externí odkaz:
https://doaj.org/article/dba035789e1b458abda6da920e441383
Publikováno v:
Movement Disorders. 37:1693-1706
In advanced stages of Parkinson's disease (PD), dyskinesia and motor fluctuations become seriously debilitating and therapeutic options become scarce. Aberrant activity of striatal cholinergic interneurons (SCIN) has been shown to be critical to PD a
Autor:
Ettel Keifman, Camila Coll, Cecilia Tubert, Rodrigo M. Paz, Juan E. Belforte, Mario G. Murer, Barbara Y. Braz
Publikováno v:
J Neurosci
In Parkinson's disease patients and rodent models, dopaminergic neuron loss (DAN) results in severe motor disabilities. In contrast, general motility is preserved after early postnatal DAN loss in rodents. Here we used mice of both sexes to show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e928ef6fb91553e7e7592eb77d3b88
https://europepmc.org/articles/PMC9698699/
https://europepmc.org/articles/PMC9698699/
Autor:
Mario Gustavo Murer, Rodrigo Manuel Paz, Yimy Amarillo, Agostina Monica Stahl, Lorena Rela, Cecilia Tubert
Publikováno v:
Movement Disorders. 36:1578-1591
Background Enhanced striatal cholinergic interneuron activity contributes to the striatal hypercholinergic state in Parkinson's disease (PD) and to levodopa-induced dyskinesia. In severe PD, dyskinesia and motor fluctuations become seriously debilita
Autor:
Roger L. Albin, William T. Dauer, Martijn L.T.M. Müller, Cecilia Tubert, Martin Sarter, D. James Surmeier, Nicolaas I. Bohnen
Publikováno v:
Movement Disorders. 33:1871-1875
In summary, what we have learned about the PPN and MLR over the past few years undermines the simplistic model that underpins the rationale for PPN DBS. Our understanding of the relevant circuitry remains rudimentary. Further, much of what we know ab
Autor:
Cecilia Tubert, Mario Gustavo Murer
Publikováno v:
The European journal of neuroscienceREFERENCES. 53(7)
Parkinson's disease (PD) is characterized by a degeneration of nigrostriatal dopaminergic neurons that results in a hypercholinergic state in the striatum. This hypercholinergic state contributes to the clinical signs of PD. However, the mechanisms t
Autor:
Sean Austin O. Lim, Asami Tanimura, Tristano Pancani, Weixing Shen, Cecilia Tubert, Dalton James Surmeier, Alexandra E. Melendez
Publikováno v:
European Journal of Neuroscience. 47:1148-1158
Giant, aspiny cholinergic interneurons (ChIs) have long been known to be key nodes in the striatal circuitry controlling goal-directed actions and habits. In recent years, new experimental approaches, like optogenetics and monosynaptic rabies virus m