Functional Characterisation of the Rare SCN5A p.E1225K Variant, Segregating in a Brugada Syndrome Familial Case, in Human Cardiomyocytes from Pluripotent Stem Cells

Autor: Nicolò Salvarani, Giovanni Peretto, Crasto Silvia, Andrea Villatore, Cecilia Thairi, Anna Santoni, Camilla Galli, Paola Carrera, Simone Sala, Sara Benedetti, Elisa Di Pasquale, Chiara Di Resta

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 11, p 9548 (2023)

Brugada syndrome (BrS) is an inherited autosomal dominant cardiac channelopathy. Pathogenic rare mutations in the SCN5A gene, encoding the alpha-subunit of the voltage-dependent cardiac Na+ channel protein (Nav1.5), are identified in 20% of BrS patie

Externí odkaz: https://doaj.org/article/3110b987a88146039a487026877f7c4e

Angiotensin-converting enzyme 2: a key enzyme in key organs

Autor: Pasquale Pagliaro, Claudia Penna, Cecilia Thairi, Giuseppe Alloatti

2020 marked the 20th anniversary of the discovery of the angiotensin-converting enzyme 2 (ACE2). This major event that changed the way we see the renin-angiotensin system today could have passed quietly. Instead, the discovery that ACE2 is a major pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576d03bc688a38fb9bcaf5418b444020
https://hdl.handle.net/2318/1899852

Extracellular vesicles (EVs) in ischemic conditioning and angiogenesis: Focus on endothelial derived EVs

Autor: Edoardo Alfì, Cecilia Thairi, Giuseppe Alloatti, Francesco Moccia, Claudia Penna, Maria Felice Brizzi, Pasquale Pagliaro, Saveria Femminò

Publikováno v: Vascular pharmacology. 140

During myocardial ischemia, timely reperfusion is critical to limit infarct area and the overall loss of cardiac contractile function. However, reperfusion further exacerbates the damage of the ischemic heart. This type of injury is known as ischemia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::545b0644a58245a2f4d03ac58cdf1fff
https://pubmed.ncbi.nlm.nih.gov/33992781

Percutaneous Coronary Intervention (PCI) Reprograms Circulating Extracellular Vesicles from ACS Patients Impairing Their Cardio-Protective Properties

Autor: Francesco Ravera, Filippo Angelini, Andrea Caccioppo, Saveria Femminò, Alberto Grosso, Luca Franchin, Cecilia Thairi, Claudia Penna, Giovanni Camussi, Stefano Comità, Claudia Cavallari, Maria Felice Brizzi, Fabrizio D'Ascenzo, Gaetano M. De Ferrari, Emilio Venturelli, Pasquale Pagliaro

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10270, p 10270 (2021)

Extracellular vesicles (EVs) are promising therapeutic tools in the treatment of cardiovascular disorders. We have recently shown that EVs from patients with Acute Coronary Syndrome (ACS) undergoing sham pre-conditioning, before percutaneous coronary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e633bf7218b590cb0c4d652e4e6338f
http://hdl.handle.net/2318/1805706