Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Cecilia Subauste"'
Autor:
Jennifer Van Grol, Cecilia Subauste, Rosa M Andrade, Koh Fujinaga, Julie Nelson, Carlos S Subauste
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11733 (2010)
Autophagy is a homeostatic mechanism of lysosomal degradation. Defective autophagy has been linked to various disorders such as impaired control of pathogens and neurodegeneration. Autophagy is regulated by a complex array of signaling pathways that
Externí odkaz:
https://doaj.org/article/f33a68cf17744c3490ee614685ff81ed
Autor:
Jose-Andres C. Portillo, Jin‐Sang Yu, Carlos S. Subauste, Samuel Hansen, M. Cecilia Subauste, Timothy S. Kern
Publikováno v:
The FASEB Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol 35, iss 3
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol 35, iss 3
While the administration of anti‐CD154 mAbs in mice validated the CD40‐CD154 pathway as a target against inflammatory disorders, this approach caused thromboembolism in humans (unrelated to CD40 inhibition) and is expected to predispose to opport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e1699534f450cacb7dd26b452eb2352
http://europepmc.org/articles/PMC8101361
http://europepmc.org/articles/PMC8101361
Autor:
Carlos S. Subauste, Jose-Andres C. Portillo, Jennifer A. Greene, Maria Cecilia Subauste, Isaac Schwartz
Publikováno v:
Immunology. 144:21-33
SummaryInhibition of the CD40–CD154 pathway controls inflammatory disorders.Unfortunately, administration of anti-CD154 monoclonal antibodiescauses thromboembolism. Blockade of signalling downstream of CD40may represent an approach to treat CD40-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29fc8edc3c9f1377c50e658f4aa16f48
https://doi.org/10.1111/imm.12361
https://doi.org/10.1111/imm.12361
Publikováno v:
Gene. 550:165-170
Retinoic acid (RA) affects multiple aspects of development, embryogenesis and cell differentiation processes. The liver is a major organ that stores RA suggesting that retinoids play an important role in the function of hepatocytes. In our previous s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f71793821020af3bb2fcefbb34be4785
https://doi.org/10.1016/j.gene.2014.07.017
https://doi.org/10.1016/j.gene.2014.07.017
Autor:
Shing Leng Chan, Joseph F. Maher, Tereza Ventura-Holman, Jose S. Subauste, M. Cecilia Subauste, Victor C. Yu, Liqin Du
Publikováno v:
Cancer Biology & Therapy. 8:2295-2303
Evasion of apoptosis plays an important role in colon cancer progression. Following loss of the Apc tumor suppressor gene in mice, the gene encoding Fem1b is upregulated early in neoplastic intestinal epithelium. Fem1b is a pro-apoptotic protein that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699610628797273401ae7765db0c5319
https://doi.org/10.4161/cbt.8.23.10262
https://doi.org/10.4161/cbt.8.23.10262
Publikováno v:
Molecular Carcinogenesis. 49:105-113
In the treatment of colon cancer, the development of resistance to apoptosis is a major factor in resistance to therapy. New molecular approaches to overcome apoptosis resistance, such as selectively upregulating proapoptotic proteins, are needed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28f697c473fac2bb7827a0a9d17e7d6b
https://doi.org/10.1002/mc.20594
https://doi.org/10.1002/mc.20594
Publikováno v:
Journal of Biological Chemistry. 280:5676-5681
PTEN is a frequently mutated tumor suppressor in malignancies. Interestingly, some malignancies exhibit undetectable PTEN protein without mutations or loss of PTEN mRNA. The cause(s) for this reduction in PTEN is unknown. Cancer cells frequently exhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fdd4ee0383867fa5fd6c75a27853a61
https://doi.org/10.1074/jbc.m405561200
https://doi.org/10.1074/jbc.m405561200
Autor:
M. Cecilia Subauste, Olivier Pertz, Christopher E. Turner, Eileen D. Adamson, Klaus M. Hahn, Sachiko Junger
Publikováno v:
The Journal of Cell Biology
Cells lacking vinculin are highly metastatic and motile. The reasons for this finding have remained unclear. Both enhanced survival and motility are critical to metastasis. Here, we show that vinculin null (vin−/−) cells and cells expressing a vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a0ba0018aa63f923aea1943a7cc640
http://europepmc.org/articles/PMC2172187
http://europepmc.org/articles/PMC2172187
Publikováno v:
The Journal of Cell Biology
Tpr is a coiled-coil protein found near the nucleoplasmic side of the pore complex. Since neither the precise localization of Tpr nor its functions are well defined, we generated antibodies to three regions of Tpr to clarify these issues. Using light
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6c514b1e2beaa0f009431a03105779
https://doi.org/10.1083/jcb.200106046
https://doi.org/10.1083/jcb.200106046
Autor:
Rose Gubitosi-Klug, Isaac Schwartz, Carlos S. Subauste, Robert C. Murphy, Simona Zarini, Reena Bapputty, M. Cecilia Subauste, Jose Andres C Portillo, Timothy S. Kern
Publikováno v:
Investigative ophthalmology & visual science, vol 55, iss 12
Purpose The cell surface receptor CD40 is required for the development of retinopathies induced by diabetes and ischemia/reperfusion. The purpose of this study was to identify signaling pathways by which CD40 triggers proinflammatory responses in ret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f0765cbef88e07e165c5951c479a3d8
https://escholarship.org/uc/item/8wb00239
https://escholarship.org/uc/item/8wb00239
