Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Cecilia Sahlgren"'
Autor:
Neeraj Prabhakar, Erica Långbacka, Ezgi Özliseli, Jesse Mattsson, Alaa Mahran, Ilida Suleymanova, Cecilia Sahlgren, Jessica M. Rosenholm, Malin Åkerfelt, Matthias Nees
Publikováno v:
Small Science, Vol 4, Iss 9, Pp n/a-n/a (2024)
Mesoporous silica nanoparticles (MSNs) have emerged as promising drug carriers that can facilitate targeted anticancer drug delivery, but efficiency studies relying on active targeting mechanisms remain elusive. This study implements in vitro 3D cocu
Externí odkaz:
https://doaj.org/article/6784873da6804a97b01d724e998aab78
Autor:
Ezgi Özliseli, Sami Şanlıdağ, Behice Süren, Alaa Mahran, Marjaana Parikainen, Cecilia Sahlgren, Jessica M. Rosenholm
Publikováno v:
Materials Today Bio, Vol 23, Iss , Pp 100865- (2023)
Hydrogels play an important role in tissue engineering due to their native extracellular matrix-like characteristics, but they are insufficient in providing the necessary stimuli to support tissue formation. Efforts to integrate bioactive cues direct
Externí odkaz:
https://doaj.org/article/4d2f4b7c942a4010ab8f14c8592425b7
Autor:
Joanna Kałafut, Jakub Czapiński, Alicja Przybyszewska-Podstawka, Arkadiusz Czerwonka, Adrian Odrzywolski, Cecilia Sahlgren, Adolfo Rivero-Müller
Publikováno v:
Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-14 (2022)
Abstract The Notch signaling pathway is a crucial regulator of cell differentiation as well as tissue organization, whose deregulation is linked to the pathogenesis of different diseases. NOTCH1 plays a key role in breast cancer progression by increa
Externí odkaz:
https://doaj.org/article/1ae1335d10fe49398ddb79f9c774c978
Autor:
Songbai Zhang, Ayako Miyakawa, Malin Wickström, Cecilia Dyberg, Lauri Louhivuori, Manuel Varas-Godoy, Kati Kemppainen, Shigeaki Kanatani, Dagmara Kaczynska, Ivar Dehnisch Ellström, Lotta Elfman, Pauliina Kronqvist, Heli Repo, Katsuhiko Mikoshiba, Cecilia Sahlgren, John Inge Johnsen, Per Uhlén
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Notch signalling is reported to be hyperactivated in oestrogen receptor-negative (ER-) breast cancer. Here the authors show that G protein-coupled receptor kinase-interacting protein 1 (GIT1) negatively regulates Notch signalling and tumour growth in
Externí odkaz:
https://doaj.org/article/bcf68ef5145e4a00816fadb87092743a
Publikováno v:
Smart Medicine, Vol 2, Iss 1, Pp n/a-n/a (2023)
Abstract Current biomedical models fail to replicate the complexity of human biology. Consequently, almost 90% of drug candidates fail during clinical trials after decades of research and billions of investments in drug development. Despite their phy
Externí odkaz:
https://doaj.org/article/0bd94bdd36cd4a0491ac5abf7bc9fcc4
Autor:
Valeriy M. Paramonov, Melanie Gerstenberg, Cecilia Sahlgren, Mika Lindén, Adolfo Rivero-Müller
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Demonstration of receptor-mediated targeting of nanoparticles to specific organs and/or cell types is an integral aim in many bionanomedicine development projects. However, engagement of targeted receptors with ligands on nanocarriers, which is the c
Externí odkaz:
https://doaj.org/article/42743c2f9fb14cce8d9fc188cc49b401
Autor:
Ilkka Paatero, Eudald Casals, Rasmus Niemi, Ezgi Özliseli, Jessica M. Rosenholm, Cecilia Sahlgren
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Mesoporous silica nanoparticles (MSNs) are extensively explored as drug delivery systems, but in depth understanding of design-toxicity relationships is still scarce. We used zebrafish (Danio rerio) embryos to study toxicity profiles of diff
Externí odkaz:
https://doaj.org/article/3030e357a6c242d8a8ea19a59c6cc4bc
Autor:
Neeraj Prabhakar, Ilya Belevich, Markus Peurla, Xavier Heiligenstein, Huan-Cheng Chang, Cecilia Sahlgren, Eija Jokitalo, Jessica M. Rosenholm
Publikováno v:
Nanomaterials, Vol 11, Iss 1, p 14 (2020)
Three-dimensional correlative light and electron microscopy (3D CLEM) is attaining popularity as a potential technique to explore the functional aspects of a cell together with high-resolution ultrastructural details across the cell volume. To perfor
Externí odkaz:
https://doaj.org/article/c9d97d920e6b41938fd97746d3fd236d
Autor:
Eike-Benjamin Braune, Yat Long Tsoi, Yee Peng Phoon, Sebastian Landor, Helena Silva Cascales, Daniel Ramsköld, Qiaolin Deng, Arne Lindqvist, Xiaojun Lian, Cecilia Sahlgren, Shao-Bo Jin, Urban Lendahl
Publikováno v:
Stem Cell Reports, Vol 6, Iss 5, Pp 643-651 (2016)
Notch signaling is an important regulator of stem cell differentiation. All canonical Notch signaling is transmitted through the DNA-binding protein CSL, and hyperactivated Notch signaling is associated with tumor development; thus it may be anticipa
Externí odkaz:
https://doaj.org/article/27589c4550a849429ff87dd9d4307da5
Publikováno v:
Micromachines, Vol 11, Iss 6, p 552 (2020)
Endothelial cells sense and respond to shear stress. Different in vitro model systems have been used to study the cellular responses to shear stress, but these platforms do not allow studies on high numbers of cells under uniform and controllable she
Externí odkaz:
https://doaj.org/article/45200878c7814c089544a6f94856c7ff