Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Cecilia S, Lindestam Arlehamn"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Neurodegenerative diseases represent a huge healthcare challenge which is predicted to increase with an aging population. Synucleinopathies, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), pre
Externí odkaz:
https://doaj.org/article/87463549cddc4af7a41b4851bd98f5e6
Autor:
Christine E Nelson, Taylor W Foreman, Eduardo R Fukutani, Keith D Kauffman, Shunsuke Sakai, Joel D Fleegle, Felipe Gomez, NIAID/DIR Tuberculosis Imaging Program, Sydnee T Gould, Cyril Le Nouën, Xueqiao Liu, Tracey L Burdette, Nicole L Garza, Bernard A P Lafont, Kelsie Brooks, Cecilia S Lindestam Arlehamn, Daniela Weiskopf, Alessandro Sette, Heather D Hickman, Ursula J Buchholz, Reed F Johnson, Jason M Brenchley, James P Oberman, Artur T L Quieroz, Bruno B Andrade, Laura E Via, Daniel L Barber
Publikováno v:
PLoS Pathogens, Vol 20, Iss 7, p e1012339 (2024)
The regulation of inflammatory responses and pulmonary disease during SARS-CoV-2 infection is incompletely understood. Here we examine the roles of the prototypic pro- and anti-inflammatory cytokines IFNγ and IL-10 using the rhesus macaque model of
Externí odkaz:
https://doaj.org/article/4f2fca22c4d14a298492237eba187e8e
Autor:
Sudhasini Panda, Jeffrey Morgan, Catherine Cheng, Mayuko Saito, Robert H. Gilman, Nelly Ciobanu, Valeriu Crudu, Donald G. Catanzaro, Antonino Catanzaro, Timothy Rodwell, Judy S. B. Perera, Teshan Chathuranga, Bandu Gunasena, Aruna D. DeSilva, Bjoern Peters, Alessandro Sette, Cecilia S. Lindestam Arlehamn
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract There is still incomplete knowledge of which Mycobacterium tuberculosis (Mtb) antigens can trigger distinct T cell responses at different stages of infection. Here, a proteome-wide screen of 20,610 Mtb-derived peptides in 21 patients mid-tre
Externí odkaz:
https://doaj.org/article/e988ebdad996476e8dbd91d75bc16235
Autor:
Paul Ogongo, Anthony Tran, Florence Marzan, David Gingrich, Melissa Krone, Francesca Aweeka, Cecilia S. Lindestam Arlehamn, Jeffrey N. Martin, Steven G. Deeks, Peter W. Hunt, Joel D. Ernst
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundInterleukin-17–producing CD4 T cells contribute to the control of Mycobacterium tuberculosis (Mtb) infection in humans; whether infection with human immunodeficiency virus (HIV) disproportionately affects distinct Th17-cell subsets that r
Externí odkaz:
https://doaj.org/article/af207d4c66734e13b49fa7ac8b2e1337
Publikováno v:
International Journal of Infectious Diseases, Vol 141, Iss , Pp 106983- (2024)
Objectives: Tuberculosis (TB) remains a global health challenge due to various factors, including delayed diagnoses leading to the spread of infection, limited efficacy of current vaccination strategies, and emergence of drug-resistant strains. Here,
Externí odkaz:
https://doaj.org/article/c7e56da5535049f49db369356c9df184
Autor:
Paige K Marty, Balaji Pathakumari, Thomas M Cox, Virginia P Van Keulen, Courtney L Erskine, Maleeha Shah, Mounika Vadiyala, Pedro Arias-Sanchez, Snigdha Karnakoti, Kelly M Pennington, Elitza S Theel, Cecilia S Lindestam Arlehamn, Tobias Peikert, Patricio Escalante
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0301659 (2024)
Clinical prediction of nontuberculous mycobacteria lung disease (NTM-LD) progression remains challenging. We aimed to evaluate antigen-specific immunoprofiling utilizing flow cytometry (FC) of activation-induced markers (AIM) and IFN-γ enzyme-linked
Externí odkaz:
https://doaj.org/article/d1de496605114f6daec64dbbf47d5485
A protective, single-visit TB vaccination regimen by co-administration of a subunit vaccine with BCG
Autor:
Karin Dijkman, Thomas Lindenstrøm, Ida Rosenkrands, Rikke Søe, Joshua S. Woodworth, Cecilia S. Lindestam Arlehamn, Rasmus Mortensen
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-13 (2023)
Abstract The only licensed tuberculosis (TB) vaccine, Bacillus Calmette Guerin (BCG), fails to reliably protect adolescents and adults from pulmonary TB, resulting in ~1.6 million deaths annually. Protein subunit vaccines have shown promise against T
Externí odkaz:
https://doaj.org/article/e5bea802532e4b85bb0bd072def421f9
Autor:
Rocky Lai, Diana N. Gong, Travis Williams, Abiola F. Ogunsola, Kelly Cavallo, Cecilia S. Lindestam Arlehamn, Sarah Acolatse, Gillian L. Beamer, Martin T. Ferris, Christopher M. Sassetti, Douglas A. Lauffenburger, Samuel M. Behar
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 13 (2023)
Heterogeneity in human immune responses is difficult to model in standard laboratory mice. To understand how host variation affects Bacillus Calmette Guerin–induced (BCG-induced) immunity against Mycobacterium tuberculosis, we studied 24 unique col
Externí odkaz:
https://doaj.org/article/fa4dabc704214397b7fdfba0992f39f3
Autor:
Stella G. Hoft, Keith D. Kauffman, Shunsuke Sakai, Cecilia S. Lindestam Arlehamn, Alessandro Sette, Daniel F. Hoft, Richard Herbert, Daniel L. Barber
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT Alternative delivery routes of the current Mycobacterium tuberculosis (Mtb) vaccine, intradermally (ID) delivered BCG, may provide better protection against tuberculosis, and be more easily administered. Here, we use rhesus macaques to compa
Externí odkaz:
https://doaj.org/article/0ede394fe9264bd2be150bdaf50800d8
Autor:
Rashmi Tippalagama, Leila Y. Chihab, Kendall Kearns, Sloan Lewis, Sudhasini Panda, Lisa Willemsen, Julie G. Burel, Cecilia S. Lindestam Arlehamn
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Antigen-specific T cells play a central role in the adaptive immune response and come in a wide range of phenotypes. T cell receptors (TCRs) mediate the antigen-specificities found in T cells. Importantly, high-throughput TCR sequencing provides a fi
Externí odkaz:
https://doaj.org/article/d886030d7409475fbb9c72670ca8056c