Exploring valrubicin’s effect on Propionibacterium acnes-induced skin inflammation in vitro and in vivo

Autor: Louise Rottboell, Sarah de Foenss, Kenneth Thomsen, Helle Christiansen, Stine M. Andersen, Thomas N. Dam, Cecilia Rosada, Karin Stenderup

Publikováno v: Dermatology Reports, Vol 7, Iss 3 (2015)

Acne is a common skin disease involving colonization with Propionibacterium acnes (P. acnes), hyperproliferation of the follicular epithelium and inflammatory events. Valrubicin is a second-generation anthracycline, non-toxic upon contact, and availa

Externí odkaz: https://doaj.org/article/e50284aba9de463e9a6e0b17da891853

Activation and inhibition of the C-terminal kinase domain of p90 ribosomal S6 kinases

Autor: Marlene Uglebjerg Fruergaard, Christine Juul Fælled Nielsen, Cecilia Rosada Kjeldsen, Lars Iversen, Jacob Lauwring Andersen, Poul Nissen

Publikováno v: Fruergaard, M U, Nielsen, C J F, Kjeldsen, C R, Iversen, L, Andersen, J L & Nissen, P 2023, ' Activation and inhibition of the C-terminal kinase domain of p90 ribosomal S6 kinases ', Life science alliance, vol. 6, no. 5 . https://doi.org/10.26508/lsa.202201425

The p90 ribosomal S6 kinases (RSKs) contain two distinct catalytic kinase domains, the N-terminal and C-terminal kinase domains (NTKD and CTKD, respectively). The activation of CTKD is regulated by phosphorylation by extracellular signal-regulated ki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b8123ffa70e73caddd3df7ef5a58b5
https://doi.org/10.1101/2022.02.18.481032

Psoriasiform skin disease in transgenic pigs with high-copy ectopic expression of human integrins α2 and β1

Autor: Karin Stenderup, Lars Bolund, Mette Schmidt, Cecilia Rosada, Torben Steiniche, Rong Li, Henrik Callesen, Lisbeth Dahl Schrøder, Thomas K. Petersen, Nicklas Heine Staunstrup, Jacob Giehm Mikkelsen, Sidsel Mortensen, Frederik Dagnæs-Hansen, Stig Purup, Ying Liu, Lars Svensson, Maria Nascimento Primo

Publikováno v: Staunstrup, N H, Stenderup, K, Mortensen, S, Primo, M N, Rosada, C, Steiniche, T, Liu, Y, Li, R, Schmidt, M, Purup, S, Dagnæs-Hansen, F, Schrøder, L D, Svensson, L, Petersen, T K, Callesen, H, Bolund, L & Mikkelsen, J G 2017, ' Psoriasiform skin disease in transgenic pigs with high-copy ectopic expression of human integrins α2 and β1 ', Disease Models & Mechanisms, vol. 10, no. 7, pp. 869-880 . https://doi.org/10.1242/dmm.028662
Disease Models & Mechanisms, Vol 10, Iss 7, Pp 869-880 (2017)
Disease Models & Mechanisms
Staunstrup, N H, Stenderup, K, Mortensen, S, Nascimento Primo, M, Rosada, C, Steiniche, T, Liu, Y, Li, R, Schmidt, M, Purup, S, Dagnæs-Hansen, F, Schrøder, L D, Svensson, L, Petersen, T K, Callesen, H, Bolund, L & Mikkelsen, J G 2017, ' Psoriasiform skin disease in transgenic pigs with high-copy ectopic expression of human integrins α2 and β1 ', Disease Models & Mechanisms, vol. 10, pp. 869-880 . https://doi.org/10.1242/dmm.028662

Psoriasis is a complex human-specific disease characterized by perturbed keratinocyte proliferation and a pro-inflammatory environment in the skin. Porcine skin architecture and immunity are very similar to that in humans, rendering the pig a suitabl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f31d332f980c6edc2d638f47ad4d7f02
https://curis.ku.dk/ws/files/184391482/869.full.pdf

Topical valrubicin application reduces skin inflammation in murine models

Autor: E. de Darkó, Karin Stenderup, Cecilia Rosada, E. Hauge, H. Christiansen, Tomas Norman Dam

Publikováno v: British Journal of Dermatology. 167:288-295

Summary Background Valrubicin is a cytostatic anthracycline analogue, lacking toxicity by skin and tissue contact, and represents a new drug with potential for topical treatment of psoriasis and nonmelanoma skin cancer (NMSC); the beneficial effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d144c5f8337caa019ea85d51b5c3b33
https://doi.org/10.1111/j.1365-2133.2012.10964.x

Hidradenitis suppurativa: a disease of the absent sebaceous gland? Sebaceous gland number and volume are significantly reduced in uninvolved hair follicles from patients with hidradenitis suppurativa

Autor: Kåre Kemp, Gregor B.E. Jemec, Bente Pakkenberg, Cecilia Rosada, Søren Kamp, Karin Stenderup, A M Fiehn, Tomas Norman Dam

Publikováno v: British Journal of Dermatology. 164:1017-1022

Summary Background The pathogenesis of hidradenitis suppurativa (HS) is not clearly understood. The nomenclature suggests an important role for the apocrine glands but recent evidence implicates the pilosebaceous unit as a more likely candidate to pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0fce408688f201c8e7fc2177f2676224
https://doi.org/10.1111/j.1365-2133.2011.10224.x