Výsledky vyhledávání - "Cecilia R. Schaaf"

Akademický článek

Immune-reactive tumor organoids system to determine the effects of microbial metabolites on cancer immunity and immunotherapies

Autor: Azza M. El-Derby, Cecilia R. Schaaf, Ethan Shelkey, Katherine L. Cook, Konstantinos I. Votanopoulos, Shay Soker

Publikováno v: Frontiers in Microbiomes, Vol 3 (2024)

Immunotherapies are a revolutionary approach to treating cancer by utilizing the body’s immune system to target and combat cancer cells. This approach offers promising alternatives to traditional chemotherapies. Its potential to induce long-lasting

Externí odkaz: https://doaj.org/article/309c00da05ab4fd880ee8e3239373246

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Akademický článek

Cisplatin exhibits superiority over MMC as a perfusion agent in a peritoneal mesothelioma patient specific organoid HIPEC platform

Autor: Steven D. Forsythe, Richard A. Erali, Nicholas Edenhoffer, William Meeker, Nadeem Wajih, Cecilia R. Schaaf, Preston Laney, Cristian D. Vanezuela, Wencheng Li, Edward A. Levine, Shay Soker, Konstantinos I. Votanopoulos

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)

Abstract Peritoneal mesothelioma (PM) is a rare malignancy with poor prognosis, representing about 10–15% of all mesothelioma cases. Herein we apply PM patient-derived tumor organoids (PTOs) in elucidating personalized HIPEC responses to bypass rar

Externí odkaz: https://doaj.org/article/b06ce63a27604f8892e9538a0600cbd8

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Akademický článek

Culture of equine intestinal epithelial stem cells after delayed tissue storage for future applications

Autor: Amy Stieler Stewart, Cecilia R. Schaaf, Brittany Veerasammy, John M. Freund, Liara M. Gonzalez

Publikováno v: BMC Veterinary Research, Vol 18, Iss 1, Pp 1-7 (2022)

Abstract Background Equine intestinal epithelial stem cells (ISCs) serve as potential targets to treat horses with severe intestinal injury. The ability to isolate and store ISCs from intestinal biopsies creates an opportunity for both in vitro exper

Externí odkaz: https://doaj.org/article/8ea0f5e5299348519bbe003976e43959

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Akademický článek

Orthotopic Transplantation of the Full-length Porcine Intestine After Normothermic Machine Perfusion

Autor: Nader Abraham, MBBS, Elsa K. Ludwig, DVM, Cecilia R. Schaaf, DVM, PhD, Brittany Veerasammy, DVM, Amy S. Stewart, DVM, PhD, Caroline McKinney, DVM, MPH, John Freund, BS, John Brassil, MS, Kannan P. Samy, MD, Qimeng Gao, MD, MHS, Riley Kahan, MBS, Donna Niedzwiecki, PhD, Diana M. Cardona, MD, Katherine S. Garman, MD, Andrew S. Barbas, MD, Debra L. Sudan, MD, Liara M. Gonzalez, DVM, PhD

Publikováno v: Transplantation Direct, Vol 8, Iss 11, p e1390 (2022)

Background. Successful intestinal transplantation is currently hindered by graft injury that occurs during procurement and storage, which contributes to postoperative sepsis and allograft rejection. Improved graft preservation may expand transplantab

Externí odkaz: https://doaj.org/article/c8e289dfaed3407f84301271645c8209

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Akademický článek

Use of Translational, Genetically Modified Porcine Models to Ultimately Improve Intestinal Disease Treatment

Autor: Cecilia R. Schaaf, Liara M. Gonzalez

Publikováno v: Frontiers in Veterinary Science, Vol 9 (2022)

For both human and veterinary patients, non-infectious intestinal disease is a major cause of morbidity and mortality. To improve treatment of intestinal disease, large animal models are increasingly recognized as critical tools to translate the basi

Externí odkaz: https://doaj.org/article/2752834bc4644bdc9e0ecbb26609a92a

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