Exploiting Sphingo- and Glycerophospholipid Impairment to Select Effective Drugs and Biomarkers for CMT1A

Autor: Davide Visigalli, Giovanna Capodivento, Abdul Basit, Roberto Fernández, Zeeshan Hamid, Barbora Pencová, Chiara Gemelli, Daniela Marubbi, Cecilia Pastorino, Adrienne M. Luoma, Christian Riekel, Daniel A. Kirschner, Angelo Schenone, José A. Fernández, Andrea Armirotti, Lucilla Nobbio

Publikováno v: Frontiers in Neurology, Vol 11 (2020)

In Charcot–Marie–Tooth type 1A (CMT1A), Schwann cells exhibit a preponderant transcriptional deficiency of genes involved in lipid biosynthesis. This perturbed lipid metabolism affects the peripheral nerve physiology and the structure of peripher

Externí odkaz: https://doaj.org/article/dab3a83382504d50bb13125de0d5d8ed

Urinary Extracellular Vesicles Carrying Klotho Improve the Recovery of Renal Function in an Acute Tubular Injury Model

Autor: Cecilia Pastorino, Jordi Molina, Cristina Grange, Paul D. Robbins, Benedetta Bussolati, Elli Papadimitriou, Ryan D. O’Kelly, Laura J. Niedernhofer, Veronica Dimuccio, Giovanni Camussi

Publikováno v: Molecular Therapy

Acute kidney injury, defined by a rapid deterioration of renal function, is a common complication in hospitalized patients. Among the recent therapeutic options, the use of extracellular vesicles (EVs) is considered a promising strategy. Here we prop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e726d5aaafe2fd3a659f6d02da884a3
http://hdl.handle.net/2318/1726934

What are we talking about when we talk about education and Chagas? A systematic review of the issue

Autor: Isabel Cecilia Pastorino, Celeste Mateyca, Mariana Sanmartino

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP

More than 110 years has passed since the first publications on Chagas disease, and it still urges the necessity of understanding it as a complex socioenvironmental issue in which components of diverse nature converge and interact beyond the biomedica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::866f9290bb182faeca30179f626085c2
https://pubmed.ncbi.nlm.nih.gov/32006572

Chronic stress effects on the apoptotic index of the adrenal cortex of pregnant rats

Autor: Carlos Alberto Soñez, Alicia Nélida Rolando, A. Bozzo, María Teresa Mugnaini, María Cristina Romanini, Isabel Cecilia Pastorino, Héctor Fernando Gauna

Publikováno v: Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al. 30(3)

Chronic stress by immobilization during gestation can alter several mechanisms that maintain homeostasis in adrenal gland. The aim of this work was to quantify the apoptotic index of adrenal cortex during mid-pregnancy and to prove cytological charac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75aba92b7f4ed4635c731c5f0f3a4a09
https://pubmed.ncbi.nlm.nih.gov/17375464

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