Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Cecilia P Sanchez"'
Autor:
Guillermo M Gomez, Giulia D'Arrigo, Cecilia P Sanchez, Fiona Berger, Rebecca C Wade, Michael Lanzer
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6, p e1011436 (2023)
The chloroquine resistance transporter (PfCRT) confers resistance to a wide range of quinoline and quinoline-like antimalarial drugs in Plasmodium falciparum, with local drug histories driving its evolution and, hence, the drug transport specificitie
Externí odkaz:
https://doaj.org/article/4dfce052391d4bef93bf212ea18e6e8b
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 4, p e1009509 (2022)
Red blood cells can withstand the harsh mechanical conditions in the vasculature only because the bending rigidity of their plasma membrane is complemented by the shear elasticity of the underlying spectrin-actin network. During an infection by the m
Externí odkaz:
https://doaj.org/article/9996aa98a6bb48bb8f54bde4b91b2f5c
Co-chaperone involvement in knob biogenesis implicates host-derived chaperones in malaria virulence.
Autor:
Mathias Diehl, Lena Roling, Lukas Rohland, Sebastian Weber, Marek Cyrklaff, Cecilia P Sanchez, Carlo A Beretta, Caroline S Simon, Julien Guizetti, Julia Hahn, Norma Schulz, Matthias P Mayer, Jude M Przyborski
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10, p e1009969 (2021)
The pathology associated with malaria infection is largely due to the ability of infected human RBCs to adhere to a number of receptors on endothelial cells within tissues and organs. This phenomenon is driven by the export of parasite-encoded protei
Externí odkaz:
https://doaj.org/article/ad3aa796df9c4134ab9f7afc1411acec
Autor:
Stefano Pegoraro, Maëlle Duffey, Thomas D Otto, Yulin Wang, Roman Rösemann, Roland Baumgartner, Stefanie K Fehler, Leonardo Lucantoni, Vicky M Avery, Alicia Moreno-Sabater, Dominique Mazier, Henri J Vial, Stefan Strobl, Cecilia P Sanchez, Michael Lanzer
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Severe malaria is a life-threatening infection with limited treatment options. Here, using a medicinal chemistry approach starting from amicarbalide, Pegoraroet al. identify a compound that, when delivered intravenously, can cure Plasmodium falciparu
Externí odkaz:
https://doaj.org/article/31209cc459aa4f289ae53a99dad149ad
Autor:
Cecilia P Sanchez, Chia-Hao Liu, Sybille Mayer, Astutiati Nurhasanah, Marek Cyrklaff, Jianbing Mu, Michael T Ferdig, Wilfred D Stein, Michael Lanzer
Publikováno v:
PLoS Genetics, Vol 10, Iss 5, p e1004382 (2014)
The emerging resistance to quinine jeopardizes the efficacy of a drug that has been used in the treatment of malaria for several centuries. To identify factors contributing to differential quinine responses in the human malaria parasite Plasmodium fa
Externí odkaz:
https://doaj.org/article/b8a0c684db08460f8f748bb50b61abfb
Autor:
Marek Cyrklaff, Shih-Ying Scott Chang, Ulrich S. Schwarz, Nicole Kilian, Pintu Patra, Christos Karathanasis, Mike Heilemann, Cecilia P. Sanchez, Michael Lanzer, Mikhail Kudryashev, Lukas Hanebutte
Publikováno v:
Molecular Microbiology. 117:274-292
The knob-associated histidine-rich protein (KAHRP) plays a pivotal role in the pathophysiology of Plasmodium falciparum malaria by forming membrane protrusions in infected erythrocytes, which anchor parasite-encoded adhesins to the membrane skeleton.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26a51819be36ea9a955f21bc93771ccb
https://doi.org/10.1111/mmi.14811
https://doi.org/10.1111/mmi.14811
Autor:
Akihisa Yamamoto, Julian Czajor, Michael Lanzer, Anil K. Dasanna, Motomu Tanaka, Benjamin Fröhlich, Alister Craig, Marek Cyrklaff, Cecilia P. Sanchez, Ulrich S. Schwarz, Christine Lansche
Publikováno v:
Biophysical Journal. 120:3315-3328
The pathology of Plasmodium falciparum malaria is largely defined by the cytoadhesion of infected erythrocytes to the microvascular endothelial lining. The complexity of the endothelial surface and the large range of interactions available for the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0900956c3974c220a4451fd4291256d
https://doi.org/10.1016/j.bpj.2021.07.003
https://doi.org/10.1016/j.bpj.2021.07.003
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2470
Super-resolution microscopy in the form of photoactivated localization microscopy (PALM) offers the possibility of counting single molecules in a cell, a cellular compartment or a molecular complex. PALM can, therefore, underpin molecular and biochem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::254c221bca3a67b0de9271e59aef33a5
https://pubmed.ncbi.nlm.nih.gov/35881366
https://pubmed.ncbi.nlm.nih.gov/35881366
Autor:
Christine Lansche, Cecilia P. Sanchez, Benjamin Fröhlich, Peter Cloetens, Judith Thoma, Yang Yang, Julian Czajor, Michael Lanzer, Motomu Tanaka
Publikováno v:
Analytical Chemistry. 92:5765-5771
While there is ample evidence suggesting that carriers of heterozygous hemoglobin S and C are protected from life-threatening malaria, little is known about the underlying biochemical mechanisms at the single cell level. Using nanofocused scanning X-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b167d016153cc17a4e933dc2f49812b0
https://doi.org/10.1021/acs.analchem.9b05111
https://doi.org/10.1021/acs.analchem.9b05111
Publikováno v:
Methods in Molecular Biology ISBN: 9781071621882
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35e8fe3ec70efcf468c2e126fea6e61e
https://doi.org/10.1007/978-1-0716-2189-9_34
https://doi.org/10.1007/978-1-0716-2189-9_34
