Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Cecilia M. Prêle"'
Publikováno v:
BMC Molecular and Cell Biology, Vol 24, Iss 1, Pp 1-15 (2023)
Abstract Background Hypoxic culture conditions have been used to study the impact of oxygen deprivation has on gene expression in a number of disease models. However, hypoxia response elements present in the promoter regions of some commonly used hou
Externí odkaz:
https://doaj.org/article/5dcb3426e9354c35ad98bc0dd3afb830
Autor:
Kady J. Braack, Tylah Miles, Farah Amat, Daniel J. Brown, Marcus D. Atlas, Jafri Kuthubutheen, Wilhelmina H.A.M. Mulders, Cecilia M. Prêle
Publikováno v:
Heliyon, Vol 9, Iss 9, Pp e19343- (2023)
Cochlear implants (CIs) allow individuals with profound hearing loss to understand speech and perceive sounds. However, not all patients obtain the full benefits that CIs can provide and the cause of this disparity is not fully understood. One possib
Externí odkaz:
https://doaj.org/article/084def3e33214542abbbf76eb1c3397d
Autor:
David W. Waters, Michael Schuliga, Prabuddha S. Pathinayake, Lan Wei, Hui-Ying Tan, Kaj E. C. Blokland, Jade Jaffar, Glen P. Westall, Janette K. Burgess, Cecilia M. Prêle, Steven E. Mutsaers, Christopher L. Grainge, Darryl A. Knight
Publikováno v:
Biomedicines, Vol 9, Iss 9, p 1162 (2021)
Idiopathic pulmonary fibrosis (IPF) is a chronic disease characterised by a dense fibrosing of the lung parenchyma. An association between IPF and cellular senescence is well established and several studies now describe a higher abundance of senescen
Externí odkaz:
https://doaj.org/article/9b887b3e6a684a2cbaf59851201b3ebd
Autor:
Cecilia M. Prêle, Thomas Iosifidis, Robin J. McAnulty, David R. Pearce, Bahareh Badrian, Tylah Miles, Sarra E. Jamieson, Matthias Ernst, Philip J. Thompson, Geoffrey J. Laurent, Darryl A. Knight, Steven E. Mutsaers
Publikováno v:
Biomedicines, Vol 9, Iss 5, p 498 (2021)
The interleukin (IL)-6 family of cytokines and exaggerated signal transducer and activator of transcription (STAT)3 signaling is implicated in idiopathic pulmonary fibrosis (IPF) pathogenesis, but the mechanisms regulating STAT3 expression and functi
Externí odkaz:
https://doaj.org/article/f48fa198e8004c7484e59b7e0c37a1fd
Autor:
Mansour A. Alghamdi, Hilary J. Wallace, Phillip E. Melton, Eric K. Moses, Andrew Stevenson, Laith N. Al-Eitan, Suzanne Rea, Janine M. Duke, Patricia L. Danielsen, Cecilia M. Prêle, Fiona M. Wood, Mark W. Fear
Publikováno v:
Biomedicines, Vol 8, Iss 7, p 181 (2020)
As a part of an abnormal healing process of dermal injuries and irritation, keloid scars arise on the skin as benign fibroproliferative tumors. Although the etiology of keloid scarring remains unsettled, considerable recent evidence suggested that ke
Externí odkaz:
https://doaj.org/article/3059482363f54e428dcac76d30032514
Publikováno v:
Biomedicines, Vol 8, Iss 5, p 101 (2020)
The timely resolution of wound healing is critical for restoring the skin as a protective barrier. The switch from a proinflammatory to a reparative microenvironment must be tightly regulated. Interleukin (IL)-6 is a key modulator of the inflammatory
Externí odkaz:
https://doaj.org/article/dd62f903becf47e3b74b06a25d474eb0
Autor:
Kaj E. C. Blokland, David W. Waters, Michael Schuliga, Jane Read, Simon D. Pouwels, Christopher L. Grainge, Jade Jaffar, Glen Westall, Steven E. Mutsaers, Cecilia M. Prêle, Janette K. Burgess, Darryl A. Knight
Publikováno v:
Pharmaceutics, Vol 12, Iss 4, p 389 (2020)
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease marked by excessive accumulation of lung fibroblasts (LFs) and collagen in the lung parenchyma. The mechanisms that underlie IPF pathophysiology are thought to reflect repeated alveola
Externí odkaz:
https://doaj.org/article/c78d3268b80d43e7a397a1b9abe04195
Autor:
Ian L. Chin, Yu Suk Choi, Fiona M. Wood, Manon Subilia, Mark W. Fear, Zhenjun Deng, Andrew W. Stevenson, Cecilia M Prêle, Nicole Hortin
Publikováno v:
Journal of Dermatological Science. 104:11-20
Background Fibroblasts found in keloid tissues are known to present an altered sensitivity to microenvironmental stimuli. However, the impact of changes in extracellular matrix stiffness on phenotypes of normal fibroblasts (NFs) and keloid fibroblast
Autor:
Cecilia M. Prêle, Claire Thomson, Darryl A. Knight, Steven E. Mutsaers, Amama Kanwal, Kaj E C Blokland, Jane Read, Michael Schuliga, Janette K. Burgess, Christopher Grainge, Nathan W. Bartlett, Allen James
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology, 321(5), L859-L871. AMER PHYSIOLOGICAL SOC
Alveolar epithelial cell (AEC) senescence is implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Mitochondrial dysfunction including release of mitochondrial DNA (mtDNA) is a feature of senescence, which led us to investigate the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9c5aa3b2b498def3fbda3c8f9e1ee71
https://research.rug.nl/en/publications/556d48b1-48e1-4762-9dc7-e55a4f14cabd
https://research.rug.nl/en/publications/556d48b1-48e1-4762-9dc7-e55a4f14cabd
Autor:
Cecilia M. Prêle, Tylah Miles, David R. Pearce, Robert J. O'Donoghue, Chris Grainge, Lucy Barrett, Kimberly Birnie, Andrew D. Lucas, Svetlana Baltic, Matthias Ernst, Catherine Rinaldi, Geoffrey J. Laurent, Darryl A. Knight, Mark Fear, Gerard Hoyne, Robin J. McAnulty, Steven E. Mutsaers
Publikováno v:
European Respiratory Journal. 60:2101469
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease associated with chronic inflammation and tissue remodelling leading to fibrosis, reduced pulmonary function, respiratory failure and death. Bleomycin (Blm)-induced lung fibrosis in m