Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Cecilia M. Canessa"'
Autor:
Rebeca González-Fernández, Julio Ávila, María F. Arteaga, Cecilia M. Canessa, Pablo Martín-Vasallo
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 4, Pp 7462-7477 (2015)
The Serum- and Glucocorticoid-induced Kinase 1, SGK1, exhibits a broad range of cellular functions that include regulation of the number of ion channels in plasma membrane and modulation of signaling pathways of cell survival. This diversity of funct
Externí odkaz:
https://doaj.org/article/5fcb46bad33d4eca890fcb4a57003064
Publikováno v:
eLife, Vol 10 (2021)
ASIC1a is a proton-gated sodium channel involved in modulation of pain, fear, addiction, and ischemia-induced neuronal injury. We report isolation and characterization of alpaca-derived nanobodies (Nbs) that specifically target human ASIC1a. Cryo-ele
Externí odkaz:
https://doaj.org/article/3015e42f8a4b4c0d9076d62eb3fb7ffc
Publikováno v:
eLife, Vol 8 (2019)
ASICs are proton-gated sodium channels expressed in neurons. Structures of chicken ASIC1 in three conformations have advanced understanding of proton-mediated gating; however, a molecular mechanism describing desensitization from open and pre-open st
Externí odkaz:
https://doaj.org/article/45151b0abd764d61baee06f2cd535376
Publikováno v:
Journal of Cellular and Molecular Medicine. 26:2852-2865
Serum-glucocorticoid-induced kinase-1 (SGK1) regulates ion homeostasis and promotes survival under stress conditions. The expression of SGK1 is under transcriptional and post-translational regulations that are frequently altered in cancer and immune
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
ASIC1a is a proton-gated sodium channel involved in modulation of pain, fear, addiction, and ischemia-induced neuronal injury. We report isolation and characterization of alpaca-derived nanobodies (Nbs) that specifically target human ASIC1a. Cryo-ele
A flexible GAS belt responds to pore mutations changing the ion selectivity of proton-gated channels
Publikováno v:
The Journal of General Physiology
Chen et al. computationally model the open conformation of the hASIC1a channel to predict that mutations that eliminate channel selectivity cause a widening of the GAS belt. Their findings implicate the GAS belt diameter in channel kinetics and ion s
Publikováno v:
The Journal of General Physiology
Acid-sensing ion channels (ASIC) play central roles in the central and peripheral nervous systems. In this paper, Chen et al. show that changes to a single arginine of a human ASIC both affect the efficacy of proton-mediated gating and delay the dese
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
ASICs are proton-gated sodium channels expressed in neurons. Structures of chicken ASIC1 in three conformations have advanced understanding of proton-mediated gating; however, a molecular mechanism describing desensitization from open and pre-open st