Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Cecilia Lorena Basiglio"'
Publikováno v:
Antioxidants & Redox Signaling. 35:808-831
Significance: Most hepatopathies are primarily or secondarily cholestatic in nature. Oxidative stress (OS) is a frequent trait among them, and impairs the machinery to generate bile by triggering e...
Autor:
Romina Belén Andermatten, María Laura Ruiz, Cecilia Lorena Basiglio, Paula María Maidagan, Nadia Ciriaci, Enrique J. Sánchez Pozzi, Ismael Ricardo Barosso, María Valeria Razori, Marcelo G. Roma, Pamela Lucía Martín
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Aims: Lipopolysaccharide (LPS) induces inflammatory cholestasis by impairing expression, localization, and function of carriers involved in bile formation, e.g. bile salt export pump (Bsep) and multidrug resistance-associated protein 2 (Mrp2). A spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8865b4c1d6be3c72ed1c39a0f84a57a1
https://linkinghub.elsevier.com/retrieve/pii/S002432052031105X
https://linkinghub.elsevier.com/retrieve/pii/S002432052031105X
Autor:
Pamela Lucía Martín, Enrique J. Sánchez Pozzi, Marcelo G. Roma, Cecilia Lorena Basiglio, María Laura Ruiz, Nadia Ciriaci, Romina Belén Andermatten, Ismael Ricardo Barosso, Paula María Maidagan, María Valeria Razori
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Lipopolysaccharide (LPS) from Gram (-) bacteria induces inflammatory cholestasis by impairing the expression/localization of transporters involved in bile formation (e.g., Bsep, Mrp2). Therapeutic options for this disease are lacking. Ursodeoxycholic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6b4f6dd6558af58ea0db23acdbd3f3
https://www.sciencedirect.com/science/article/abs/pii/S000629521930228X
https://www.sciencedirect.com/science/article/abs/pii/S000629521930228X
Autor:
Marcelo G. Roma, Daniel E. Francés, Alejandra I. Martínez, Cecilia Lorena Basiglio, Enrique J. Sánchez Pozzi, Gerardo B. Pisani, Sandra Mónica María Arriaga, Paula Ceccatto, Pamela Lucía Martín, María Valeria Razori
Publikováno v:
Clinical science (London, England : 1979). 133(1)
We previously demonstrated in in vitro and ex vivo models that physiological concentrations of unconjugated bilirubin (BR) prevent oxidative stress (OS)-induced hepatocanalicular dysfunction and cholestasis. Here, we aimed to ascertain, in the whole
Autor:
Flavia Daniela Toledo, Andrés Ernesto Zucchetti, Cecilia Lorena Basiglio, Andrea Carolina Boaglio, Marcelo G. Roma, Ismael Ricardo Barosso, Enrique J. Sánchez Pozzi
Publikováno v:
RepHipUNR (UNR)
Universidad Nacional de Rosario
instacron:UNR
Universidad Nacional de Rosario
instacron:UNR
In previous studies, we showed that the pro-oxidant model agent tert-butyl hydroperoxide (tBuOOH) induces alterations in hepatocanalicular secretory function by activating Ca2+-dependent protein kinase C isoforms (cPKC), via F-actin disorganization f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9c49a6d783fd837395f53003946ac36
Autor:
Enrique J. Sánchez Pozzi, Justina E. Ochoa, Cecilia Lorena Basiglio, Leonardo Martín Pérez, Marcelo G. Roma, Flavia Daniela Toledo
Publikováno v:
Archives of Toxicology. 88:1695-1709
Oxidative stress (OS) is a common event in most hepatopathies, leading to mitochondrial permeability transition pore (MPTP) formation and further exacerbation of both OS from mitochondrial origin and cell death. Intracellular Ca2+ increase plays a pe
Autor:
Hebe Bottai, Héctor Fabián Pelusa, Sandra Mónica María Arriaga, Eleonora Pezzarini, Jorge Musuruana, Stella Maris Daniele, Mariela Bearzotti, M. J. Svetaz, Cecilia Lorena Basiglio
Publikováno v:
RepHipUNR (UNR)
Universidad Nacional de Rosario
instacron:UNR
Universidad Nacional de Rosario
instacron:UNR
Background: Antiphospholipid syndrome is an autoimmune disease characterized by thrombosis, fetal losses and thrombocytopenia associated to antiphospholipid antibodies. They are directed to phospholipids, such as cardiolipins (anticardiolipin) and lu
Publikováno v:
Chemico-Biological Interactions. 188:386-392
Ursodeoxycholic acid is widely used as a therapeutic agent for the treatment of cholestatic liver diseases. In these hepatopathies, the bile secretory failure produces accumulation of endogenous, tensioactive bile salts, leading to plasma membrane da
Autor:
Fabián Pelusa, Sandra Mónica María Arriaga, Cecilia Lorena Basiglio, Adriana M. Almará, Aldo D. Mottino, Jaime Kapitulnik
Publikováno v:
Clinical Science. 118:99-113
Complement, an important effector mechanism of the immune system, is an enzymatic cascade of approx. 30 serum proteins leading to the amplification of a specific humoral response. It can be activated through the classical or alternative pathways, or
Publikováno v:
Chemico-Biological Interactions. 179:297-303
Silymarin (SIL) is a natural extract with hepatoprotective properties composed mainly of flavonolignans, with silibinin (SB) being its principal constituent. SB is thought to be the main responsible for SIL hepatoprotective properties, although this