Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Cecilia Kwong"'
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Solid stress impairs lymphocyte infiltration into lymph-node metastases
Autor: Timothy P. Padera, Ethel R. Pereira, Hengbo Zhou, Rohin Banerji, Sue Zhang, Victoria Xiao, Zixiong Wang, Hadi Tavakoli Nia, Jan Willem Maurits van Wijnbergen, Ivy X. Chen, Peigen Huang, Cecilia Kwong, Dennis Jones, Benjamin J. Vakoc, Pin-Ji Lei
Publikováno v: Nat Biomed Eng
Strong and durable anticancer immune responses are associated with the generation of activated cancer-specific T cells in the draining lymph nodes. However, cancer cells can colonize lymph nodes and drive tumour progression. Here, we show that lympho
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7fefd7266a530a654a8fe22aded7152
https://doi.org/10.1038/s41551-021-00766-1
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3
Abstract 557: Engineering off-the-shelf anti mesothelin t-cell receptor fusion construct (TRuC™) t-cells
Autor: Julie Donaghey, Cecilia Kwong, Allison Powell, Troy Patterson, Ella Liberzon, Richard Decker, Julio Gomez Rodriguez, Darby Kreienberg, Jennifer Bian, Urmi Patankar, Holly Horton, Jian Ding, Robert Hofmeister, Dario Gutierrez, Robert Tighe
Publikováno v: Cancer Research. 82:557-557
We have previously described the generation of autologous T Cell Receptor Fusion Construct (TRuC™) T cells which are engineered to express a fusion protein comprised of an antibody-derived binder tethered to the extracellular domain of the CD3ε si
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f262d6fc52763424dab5f2723319c894
https://doi.org/10.1158/1538-7445.am2022-557
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5
Abstract 940: Development of ONCR-177, an miR-attenuated oncolytic HSV-1 designed to potently activate systemic antitumor immunity
Autor: Peter Grzesik, Caitlin Goshert, Prajna Behera, Jennifer S. Lee, Brian B. Haines, Cecilia Kwong, Allison Colthart, Lingxin Kong, Michael Ball, Terry Farkaly, Jacqueline Gursha, Christophe Quéva, Edward M. Kennedy, Agnieszka Denslow, Daniel Wambua, Lorena Lerner
Publikováno v: Cancer Research. 79:940-940
ONCR-177 is a highly modified recombinant oncolytic Herpes Simplex Virus (oHSV) designed to be a safe and efficacious therapy for the treatment of solid tumor indications. Complementary safety mechanisms, such as tissue-specific miR attenuation of es
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d75f3e4b9f949807dd5ee979edf1f7e
https://doi.org/10.1158/1538-7445.am2019-940
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6
Abstract 1452: Development of ONCR-148, a miR-attenuated oncolytic HSV-1 designed to potently activate antitumor T cell response
Autor: Agnieszka Denslow, Brian B. Haines, Michael S. Ball, Jacqueline Gursha, Daniel Wambua, Cecilia Kwong, Lingxin Kong, Allison Colthart, Prajna Behera, Peter Grzesik, Jennifer Lee, Terry Farkaly, Caitlin Goshert, Edward M. Kennedy, Lorena Lerner, Christophe Quéva
Publikováno v: Cancer Research. 79:1452-1452
Oncolytic viruses, through cancer cell-selective lysis and accompanying release of danger signals that promote immune activation, have demonstrated antitumor efficacy in monotherapy of metastatic melanoma and have shown promising activity in combinat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4746d8b469d52d8e8cfd51bd2033083
https://doi.org/10.1158/1538-7445.am2019-1452
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7
Abstract 4698: ONCR-1, a novel herpes simplex virus expressing MMP9 and ULBP3 transgenes, evokes potent oncolysis and development of antitumor immune responses
Autor: Weiguo Yao, Alexandra Hicks, Jacqueline Gursha, Michael Paglia, Lorenz Ponce, Jingzang Miu, Terry Farkaly, Joseph C. Glorioso, Daniel Wambua, Christophe Quéva, Michael Ball, Cecilia Kwong, Finer Mitchell H, Kyle Grant, Paola Grandi, Laura Viggiano Salta
Publikováno v: Cancer Research. 78:4698-4698
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor associated with poor prognosis and resistance to current therapies. ONCR-1 is a novel oncolytic herpes simplex virus type-1 vector in development for the treatment of GBM. ONCR-1 utiliz
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc51e0b4eb6496f98122ef71a7d21efa
https://doi.org/10.1158/1538-7445.am2018-4698
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8
Increased neurokinin B (Tac2) expression in the mouse arcuate nucleus is an early marker of pubertal onset with differential sensitivity to sex steroid-negative feedback than Kiss1
Autor: John C. Gill, Ursula B. Kaiser, Shuyun Xu, Cecilia Martin, Cecilia Kwong, Víctor M. Navarro, Rona S. Carroll, Donald K. Clifton, Sekoni D. Noel, Robert A. Steiner
Publikováno v: Endocrinology. 153(10)
At puberty, neurokinin B (NKB) and kisspeptin (Kiss1) may help to amplify GnRH secretion, but their precise roles remain ambiguous. We tested the hypothesis that NKB and Kiss1 are induced as a function of pubertal development, independently of the pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b247b71c2704ed6a40ad0a76e703ef3
https://pubmed.ncbi.nlm.nih.gov/22893725
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