Decreased expression of caveolin 1 in patients with systemic sclerosis: Crucial role in the pathogenesis of tissue fibrosis

Autor: Megan Musick, Sergio A. Jimenez, Francesco Del Galdo, Cecilia J. de Almeida, Jean-Francois Jasmin, Federica Sotgia, Michael P. Lisanti

Publikováno v: Del Galdo, F, Sotgia, F, De Almeida, C J, Jasmin, J F, Musick, M, Lisanti, M P & Jiménez, S A 2008, ' Decreased expression of caveolin 1 in patients with systemic sclerosis: Crucial role in the pathogenesis of tissue fibrosis ', Arthritis Care & Research, vol. 58, no. 9, pp. 2854-2865 . https://doi.org/10.1002/art.23791

Objective. Recent studies have implicated caveolin 1 in the regulation of transforming growth factor β (TGFβ) downstream signaling. Given the crucial role of TGFβ in the pathogenesis of systemic sclerosis (SSc), we sought to determine whether cave

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::650da6ae3960d00e59dc9939218cf0bb
https://doi.org/10.1002/art.23791

Caveolin-1-Deficient Mice Show Defects in Innate Immunity and Inflammatory Immune Response during Salmonella enterica Serovar Typhimurium Infection

Autor: Terence M. Williams, Cecilia J. de Almeida, Philippe G. Frank, Richard G. Pestell, Alex W. Cohen, Herbert B. Tanowitz, Jiangwei Li, Michael P. Lisanti, Freddy A. Medina, Elliott Dew, Gloria Bonuccelli

Publikováno v: Infection and Immunity. 74:6665-6674

A number of studies have shown an association of pathogens with caveolae. To this date, however, there are no studies showing a role for caveolin-1 in modulating immune responses against pathogens. Interestingly, expression of caveolin-1 has been sho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fca1b088eac20ac2ae830f0353c5e8a
https://doi.org/10.1128/iai.00949-06

Genetic ablation of caveolin-2 sensitizes mice to bleomycin-induced injury

Autor: Michael P. Lisanti, Francesco Del Galdo, Jean-Francois Jasmin, Cecilia J. de Almeida

Caveolar domains act as platforms for the organization of molecular complexes involved in signal transduction. Caveolin proteins, the principal structural components of caveolae, have been involved in many cellular processes. Caveolin-1 (Cav-1) and c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aef5949fa73b80f0b6c57db99da0e1d
https://europepmc.org/articles/PMC3755075/

Trypanosoma cruzi infection of cultured adipocytes results in an inflammatory phenotype

Autor: Vicki L. Braunstein, Michael P. Lisanti, Mahalia S. Desruisseaux, Philipp E. Scherer, Mauro M. Teixeira, Herbert B. Tanowitz, Chris Albanese, Louis M. Weiss, Cecilia J. de Almeida, Niranjan Thiruvur, Fnu Nagajyothi

Publikováno v: Obesity (Silver Spring, Md.). 16(9)

Infection with Trypanosoma cruzi, the etiologic agent of Chagas disease is accompanied by an intense inflammatory reaction. Our laboratory group has identified adipose tissue as one of the major sites of inflammation during disease progression. Becau

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e48004831a4469cd785bbc77b719117
https://pubmed.ncbi.nlm.nih.gov/19186325

Trypanosoma cruzi infection induces proliferation of vascular smooth muscle cells

Autor: Michael P. Lisanti, Ghada S. Hassan, Richard G. Pestell, Mahalia S. Desruisseaux, Boumediene Bouzahzah, Chris Albanese, Louis M. Weiss, Huan Huang, Cecilia J. de Almeida, Shankar Mukherjee, George J. Christ, Herbert B. Tanowitz, Stefka B. Petkova, Fnu Nagajyothi

Publikováno v: Infection and immunity. 74(1)

Trypanosoma cruzi infection causes cardiomyopathy and vasculopathy. Previous studies have demonstrated that infection of human umbilical vein endothelial and smooth muscle cells resulted in activation of extracellular signal-regulated kinase (ERK). I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e7ad659a85101fd53d277620b098f2
https://pubmed.ncbi.nlm.nih.gov/16368968