Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Cecilia Giacomini"'
Autor:
Teresa Freire, Mercedes Landeira, Cecilia Giacomini, María Florencia Festari, Álvaro Pittini, Viviana Cardozo, Alina Brosque, Leticia Monin, Valeria da Costa, Paula Faral-Tello, Carlos Robello, Eduardo Osinaga
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 15032 (2022)
Lung cancer remains the leading cause of cancer mortality worldwide. Thus, the development of strategies against this type of cancer is of high value. Parasite infections can correlate with lower cancer incidence in humans and their use as vaccines h
Externí odkaz:
https://doaj.org/article/dadfa610f1e245d09bd10f276284fcad
Publikováno v:
Biochemistry and Biophysics Reports, Vol 26, Iss , Pp 100940- (2021)
Background: Sialic acids are widely distributed in nature and have biological relevance owing to their varied structural and functional roles. Immobilized neuraminidase can selectively remove terminal N-acetyl neuraminic acid from glycoproteins witho
Externí odkaz:
https://doaj.org/article/a89c4701a3bd4f4e86152cae625653a0
Autor:
Ernesto Rodríguez, Verónica Noya, Laura Cervi, María Laura Chiribao, Natalie Brossard, Carolina Chiale, Carlos Carmona, Cecilia Giacomini, Teresa Freire
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 12, p e0004234 (2015)
Helminths express various carbohydrate-containing glycoconjugates on their surface, and they release glycan-rich excretion/secretion products that can be very important in their life cycles, infection and pathology. Recent evidence suggests that para
Externí odkaz:
https://doaj.org/article/b1ac7ce769f240c4b3690169eb852218
Autor:
María Luciana Negro-Demontel, Paolo Saccardo, Cecilia Giacomini, Rafael Joaquín Yáñez-Muñoz, Neus Ferrer-Miralles, Esther Vazquez, Antonio Villaverde, Hugo Peluffo
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)
Traumatic brain injury (TBI) remains as one of the leading causes of mortality and morbidity worldwide and there are no effective treatments currently available. Gene therapy applications have emerged as important alternatives for the treatment of di
Externí odkaz:
https://doaj.org/article/f099278fdd284ed5a6437c7e91d776f9
Publikováno v:
Biotechnology and Applied Biochemistry. 69:209-220
The elucidation of glycans biological function is essential to understand their role in biological processes, both normal and pathological. Immobilized glycoenzymes are excellent tools for this purpose as they can selectively release glycans from gly
Autor:
Cecilia Porciúncula González, Carolina Fontana, Karina Mariño, Alejandro J. Cagnoni, Cecilia Giacomini, Gabriela Irazoqui, Patricia Saenz-Méndez
Publikováno v:
Carbohydrate Research. 472:1-15
Galectins are a family of carbohydrate-recognizing proteins that by interacting with specific glycoepitopes can mediate important biological processes, including immune cell homeostasis and activation of tolerogenic circuits. Among the different memb
Autor:
Karina Mariño, Cecilia Giacomini, Gabriela Irazoqui, Cecilia Porciúncula-González, Patricia Saenz-Méndez, Alejandro J. Cagnoni, Carolina Fontana
Publikováno v:
Bioorganicmedicinal chemistry. 44
Galectins, soluble lectins widely expressed intra- and extracellularly in different cell types, play major roles in deciphering the cellular glycocode. Galectin-1 (Gal-1), a prototype member of this family, presents a carbohydrate recognition domain
Autor:
Teresa Freire, Juan J. García Vallejo, Yvette van Kooyk, Hakan Kalay, Ernesto Rodríguez, Cecilia Giacomini, Natalie Brossard, Karen Francia
Publikováno v:
Enzyme and microbial technology, 117, 45-55. Elsevier Inc.
Rodríguez, E, Francia, K, Brossard, N, García Vallejo, J J, Kalay, H, van Kooyk, Y, Freire, T & Giacomini, C 2018, ' Immobilization of β-galactosidase and α-mannosidase onto magnetic nanoparticles : A strategy for increasing the potentiality of valuable glycomic tools for glycosylation analysis and biological role determination of glycoconjugates ', Enzyme and microbial technology, vol. 117, pp. 45-55 . https://doi.org/10.1016/j.enzmictec.2018.05.012
Rodríguez, E, Francia, K, Brossard, N, García Vallejo, J J, Kalay, H, van Kooyk, Y, Freire, T & Giacomini, C 2018, ' Immobilization of β-galactosidase and α-mannosidase onto magnetic nanoparticles : A strategy for increasing the potentiality of valuable glycomic tools for glycosylation analysis and biological role determination of glycoconjugates ', Enzyme and microbial technology, vol. 117, pp. 45-55 . https://doi.org/10.1016/j.enzmictec.2018.05.012
Glycans present in biological glycoconjugates have several structural and functional roles. Elucidation of glycan structure and biological function is critical to understand their role in physiological and pathogenic process, enabling the development
Autor:
Gabriela Irazoqui, Laura Franco Fraguas, Beatriz M. Brena, Silvia Soule, Cecilia Porciúncula González, Ernesto Rodríguez, Cecilia Giacomini
Publikováno v:
Biocatalysis and Biotransformation. 33:197-207
Glycosidases represent excellent green chemistry alternatives as catalysts for the synthesis of glycosides, and in particular their stereoselectivity allows the production of anomerically pure glycosides, in only one reaction step using mild reaction
Autor:
Juan J. Garcia-Vallejo, Yvette van Kooyk, Natalie Brossard, Cecilia Giacomini, Hakan Kalay, Ernesto Rodríguez, Verónica Noya, Teresa Freire
Publikováno v:
Scientific Reports, 7. Nature Publishing Group
Rodríguez, E, Kalay, H, Noya, V, Brossard, N, Giacomini, C, van Kooyk, Y, García-Vallejo, J J & Freire, T 2017, ' Fasciola hepatica glycoconjugates immuneregulate dendritic cells through the Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin inducing T cell anergy ', Scientific Reports, vol. 7, pp. 46748 . https://doi.org/10.1038/srep46748
Scientific Reports
Rodríguez, E, Kalay, H, Noya, V, Brossard, N, Giacomini, C, van Kooyk, Y, García-Vallejo, J J & Freire, T 2017, ' Fasciola hepatica glycoconjugates immuneregulate dendritic cells through the Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin inducing T cell anergy ', Scientific Reports, vol. 7, pp. 46748 . https://doi.org/10.1038/srep46748
Scientific Reports
Dendritic cell-specific ICAM-3 grabbing non-integrin (DC-SIGN) expressed on a variety of DCs, is a C-type lectin receptor that recognizes glycans on a diverse range of pathogens, including parasites. The interaction of DC-SIGN with pathogens triggers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b611cf95f06ee78ddf936a321f9ecbe
https://research.vumc.nl/en/publications/17c585a9-17bb-4d2c-bdd8-7436ad04e9c1
https://research.vumc.nl/en/publications/17c585a9-17bb-4d2c-bdd8-7436ad04e9c1