Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Cecilia Ferrantini"'
Autor:
Beatrice Scellini, Nicoletta Piroddi, Marica Dente, J. Manuel Pioner, Cecilia Ferrantini, Corrado Poggesi, Chiara Tesi
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 9784 (2024)
Omecamtiv mecarbil (OM) is a small molecule that has been shown to improve the function of the slow human ventricular myosin (MyHC) motor through a complex perturbation of the thin/thick filament regulatory state of the sarcomere mediated by binding
Externí odkaz:
https://doaj.org/article/d6dae918ed444ff2b7450ae5f53d5822
Autor:
Josè Manuel Pioner, Lorenzo Santini, Chiara Palandri, Marianna Langione, Bruno Grandinetti, Silvia Querceto, Daniele Martella, Costanza Mazzantini, Beatrice Scellini, Lucrezia Giammarino, Flavia Lupi, Francesco Mazzarotto, Aoife Gowran, Davide Rovina, Rosaria Santoro, Giulio Pompilio, Chiara Tesi, Camilla Parmeggiani, Michael Regnier, Elisabetta Cerbai, David L. Mack, Corrado Poggesi, Cecilia Ferrantini, Raffaele Coppini
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/09df826ed4e8452db5de3039b389a56f
Autor:
Josè Manuel Pioner, Lorenzo Santini, Chiara Palandri, Marianna Langione, Bruno Grandinetti, Silvia Querceto, Daniele Martella, Costanza Mazzantini, Beatrice Scellini, Lucrezia Giammarino, Flavia Lupi, Francesco Mazzarotto, Aoife Gowran, Davide Rovina, Rosaria Santoro, Giulio Pompilio, Chiara Tesi, Camilla Parmeggiani, Michael Regnier, Elisabetta Cerbai, David L. Mack, Corrado Poggesi, Cecilia Ferrantini, Raffaele Coppini
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Cardiomyocytes differentiated from human induced Pluripotent Stem Cells (hiPSC- CMs) are a unique source for modelling inherited cardiomyopathies. In particular, the possibility of observing maturation processes in a simple culture dish opens novel p
Externí odkaz:
https://doaj.org/article/95e6e0e9e12446fa8397f9dbba59be9f
Autor:
Josè Manuel Pioner, Giulia Vitale, Francesca Gentile, Beatrice Scellini, Nicoletta Piroddi, Elisabetta Cerbai, Iacopo Olivotto, Jil Tardiff, Raffaele Coppini, Chiara Tesi, Corrado Poggesi, Cecilia Ferrantini
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Atrial dilation and atrial fibrillation (AF) are common in Hypertrophic CardioMyopathy (HCM) patients and associated with a worsening of prognosis. The pathogenesis of atrial myopathy in HCM remains poorly investigated and no specific association wit
Externí odkaz:
https://doaj.org/article/06e829932fea48f2bca1c796e4de4f36
Autor:
Francesco Giardini, Erica Lazzeri, Giulia Vitale, Cecilia Ferrantini, Irene Costantini, Francesco S. Pavone, Corrado Poggesi, Leonardo Bocchi, Leonardo Sacconi
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Proper three-dimensional (3D)-cardiomyocyte orientation is important for an effective tension production in cardiac muscle. Cardiac diseases can cause severe remodeling processes in the heart, such as cellular misalignment, that can affect both the e
Externí odkaz:
https://doaj.org/article/45e7f98f680e4abbb1bfc477a0996276
Autor:
M. Caroline Müllenbroich, Allen Kelly, Corey Acker, Gil Bub, Tobias Bruegmann, Anna Di Bona, Emilia Entcheva, Cecilia Ferrantini, Peter Kohl, Stephan E. Lehnart, Marco Mongillo, Camilla Parmeggiani, Claudia Richter, Philipp Sasse, Tania Zaglia, Leonardo Sacconi, Godfrey L. Smith
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Optical techniques for recording and manipulating cellular electrophysiology have advanced rapidly in just a few decades. These developments allow for the analysis of cardiac cellular dynamics at multiple scales while largely overcoming the drawbacks
Externí odkaz:
https://doaj.org/article/a9e4c73a9f3a472da2cc8abc80c6b389
Autor:
Raffaele Coppini, MD, PhD, Cecilia Ferrantini, MD, PhD, Josè Manuel Pioner, PhD, Lorenzo Santini, MS, Zhinuo J. Wang, PhD, Chiara Palandri, MS, Marina Scardigli, PhD, Giulia Vitale, MS, Leonardo Sacconi, PhD, Pierluigi Stefàno, MD, Laura Flink, MD, Katherine Riedy, MD, Francesco Saverio Pavone, PhD, Elisabetta Cerbai, PhD, Corrado Poggesi, MD, Alessandro Mugelli, MD, Alfonso Bueno-Orovio, PhD, Iacopo Olivotto, MD, Mark V. Sherrid, MD
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 7, Pp 795-813 (2019)
Summary: Disopyramide is effective and safe in patients with obstructive hypertrophic cardiomyopathy. However, its cellular and molecular mechanisms of action are unknown. We tested disopyramide in cardiomyocytes from the septum of surgical myectomy
Externí odkaz:
https://doaj.org/article/383410aaa4f04130b18b186ad5f7d1d6
Autor:
Josè Manuel Pioner, Alessandra Fornaro, Raffaele Coppini, Nicole Ceschia, Leonardo Sacconi, Maria Alice Donati, Silvia Favilli, Corrado Poggesi, Iacopo Olivotto, Cecilia Ferrantini
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Familial dilated cardiomyopathy (DCM) is mostly caused by mutations in genes encoding cytoskeletal and sarcomeric proteins. In the pediatric population, DCM is the predominant type of primitive myocardial disease. A severe form of DCM is associated w
Externí odkaz:
https://doaj.org/article/c88d4495593646f98d60cab2621f4ff5
Autor:
Kathleen C. Woulfe, Claudia Ferrara, Jose Manuel Pioner, Jennifer H. Mahaffey, Raffaele Coppini, Beatrice Scellini, Cecilia Ferrantini, Nicoletta Piroddi, Chiari Tesi, Corrado Poggesi, Mark Jeong
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 6 (2019)
Myofibril based mechanical studies allow evaluation of sarcomeric protein function. We describe a novel method of obtaining myofibrils from primary cardiomyocyte culture. Adult rat ventricular myocytes (ARVMs) were obtained by enzymatic digestion and
Externí odkaz:
https://doaj.org/article/595589edb5034a48a247cab85f612073
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Asynchronous Ca2+ release promotes non-homogeneous myofilament activation, leading to mechanical dysfunction, as well as initiation of propagated calcium waves and arrhythmias. Recent advances in microscopy techniques have allowed for optical recordi
Externí odkaz:
https://doaj.org/article/db474991e8f14f528cf82ce2906f5b3e