Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Cecilia Carnrot"'
Autor:
Barnabas G. Williams, Lloyd D. W. King, David Pulido, Doris Quinkert, Amelia M. Lias, Sarah E. Silk, Robert J. Ragotte, Hannah Davies, Jordan R. Barrett, Kirsty McHugh, Cassandra A. Rigby, Daniel G. W. Alanine, Lea Barfod, Michael W. Shea, Li An Cowley, Rebecca A. Dabbs, David J. Pattinson, Alexander D. Douglas, Oliver R. Lyth, Joseph J. Illingworth, Jing Jin, Cecilia Carnrot, Vinayaka Kotraiah, Jayne M. Christen, Amy R. Noe, Randall S. MacGill, C. Richter King, Ashley J. Birkett, Lorraine A. Soisson, Katherine Skinner, Kazutoyo Miura, Carole A. Long, Matthew K. Higgins, Simon J. Draper
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Reticulocyte-binding protein homologue 5 (RH5), a leading blood-stage Plasmodium falciparum malaria vaccine target, interacts with cysteine-rich protective antigen (CyRPA) and RH5-interacting protein (RIPR) to form an essential heterotrimeri
Externí odkaz:
https://doaj.org/article/c0357f954cd04ff984155d03439a386e
Autor:
Cecilia Carnrot, Berit Carow, Anna-Karin E. Palm, Eray Akpinar, Per-Henrik Helgesson, Ingrid Lekberg Osterman, Emelie Bringeland, Bryant Foreman, Nita Patel, Johan Bankefors, Louis Fries, Linda Stertman
Publikováno v:
Frontiers in Drug Delivery, Vol 3 (2023)
Novel adjuvants are extensively utilized in the development of safe and effective vaccines against emerging pathogens. Matrix-M™ adjuvant is a saponin-based adjuvant used in several active clinical development programs and in widespread use in the
Externí odkaz:
https://doaj.org/article/4481fd86955545dfac2655cb03706e44
Autor:
Linda Stertman, Anna-Karin E. Palm, Behdad Zarnegar, Berit Carow, Carolina Lunderius Andersson, Sofia E. Magnusson, Cecilia Carnrot, Vivek Shinde, Gale Smith, Gregory Glenn, Louis Fries, Karin Lövgren Bengtsson
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 19, Iss 1 (2023)
Matrix-M™ adjuvant is a key component of several novel vaccine candidates. The Matrix-M adjuvant consists of two distinct fractions of saponins purified from the Quillaja saponaria Molina tree, combined with cholesterol and phospholipids to form 40
Externí odkaz:
https://doaj.org/article/f73e86e78de8490f9c7688c046ee0852
Autor:
Jure Piškur, Michael P. B. Sandrini, Anders R. Clausen, Cecilia Carnrot, U. Kosinska, Staffan Eriksson, Hans Eklund, Liya Wang
Publikováno v:
FEBS Journal. 274:727-737
Thymidine kinase (TK) is the key enzyme in salvaging thymidine to produce thymidine monophosphate. Owing to its ability to phosphorylate nucleoside analogue prodrugs, TK has gained attention as a rate-limiting drug activator. We describe the structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33cc0dfbd83a592e7ffbeb761310ef15
https://doi.org/10.1111/j.1742-4658.2006.05617.x
https://doi.org/10.1111/j.1742-4658.2006.05617.x
Autor:
U. Kosinska, Nils-Egil Mikkelsen, Liya Wang, Martin Welin, Staffan Eriksson, Birgitte Munch-Petersen, Chunying Zhu, Cecilia Carnrot, Hans Eklund
Publikováno v:
Proceedings of the National Academy of Sciences. 101:17970-17975
Cytosolic thymidine kinase 1, TK1, is a well known cell-cycle-regulated enzyme of importance in nucleotide metabolism as well as an activator of antiviral and anticancer drugs such as 3′-azido-3′-deoxythymidine (AZT). We have now determined the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62722bb9521602c944c58cac08058a2e
https://doi.org/10.1073/pnas.0406332102
https://doi.org/10.1073/pnas.0406332102
Antibodies against type II collagen (CII) are essential for development of collagen-induced arthritis (CIA), but how and where the B-cell response to CII is initiated is not fully known. We show here that naive DBA/1 mice display naturally reactive I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a403029ab167112cedc759c1d91b4c
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-109185
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-109185
Autor:
Werner Tjarks, Susan R. Vogel, Youngjoo Byun, Cecilia Carnrot, Andrew J. Phipps, Staffan Eriksson, Rohit Tiwari
Publikováno v:
ChemInform. 39
Nineteen lipophilic thymidine phosphate-mimicking compounds were designed and synthesized as potential inhibitors of thymidine monophosphate kinase of Bacillus anthracis, a Gram-positive bacterium that causes anthrax. These thymidine analogues were s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca808729babcea5448076c2911f4afa9
https://doi.org/10.1002/chin.200831206
https://doi.org/10.1002/chin.200831206
Publikováno v:
Protein science : a publication of the Protein Society. 17(9)
Bacillus anthracis is well known in connection with biological warfare. The search for new drug targets and antibiotics is highly motivated because of upcoming multiresistant strains. Thymidylate kinase is an ideal target since this enzyme is at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36fbf1542586fe5086fbc4a2b5cc8213
https://pubmed.ncbi.nlm.nih.gov/18523102
https://pubmed.ncbi.nlm.nih.gov/18523102
Autor:
Cecilia Carnrot, Susan R. Vogel, Rohit Tiwari, Werner Tjarks, Staffan Eriksson, Youngjoo Byun, Andrew J. Phipps
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 27(3)
Nineteen lipophilic thymidine phosphate-mimicking compounds were designed and synthesized as potential inhibitors of thymidine monophosphate kinase of Bacillus anthracis, a Gram-positive bacterium that causes anthrax. These thymidine analogues were s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2271e72e281108312e8fe971fb15bb56
https://pubmed.ncbi.nlm.nih.gov/18260009
https://pubmed.ncbi.nlm.nih.gov/18260009
Autor:
Liya Wang, Andrew J. Phipps, Cecilia Carnrot, Werner Tjarks, Youngjoo Byun, Susan R. Vogel, Staffan Eriksson
Publikováno v:
Biological Chemistry. 387
Bacillus anthracis, which causes anthrax, has attracted attention because of its potential use as a biological weapon. The risk of multidrug resistance against B. anthracis increases the need for antibiotics with new molecular targets. Nucleoside ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f836a8d78d5340c443a726ec1debbdbd
https://doi.org/10.1515/bc.2006.196
https://doi.org/10.1515/bc.2006.196