Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Cecilia B Levandowski"'
Autor:
Cecilia B Levandowski, Taylor Jones, Margaret Gruca, Sivapriya Ramamoorthy, Robin D Dowell, Dylan J Taatjes
Publikováno v:
PLoS Biology, Vol 19, Iss 8, p e3001364 (2021)
The naturally occurring Δ40p53 isoform heterotetramerizes with wild-type p53 (WTp53) to regulate development, aging, and stress responses. How Δ40p53 alters WTp53 function remains enigmatic because their co-expression causes tetramer heterogeneity.
Externí odkaz:
https://doaj.org/article/94aa714894df457982ab202df1437cf9
Autor:
Daniel P. Nussbaum, Colin A. Martz, Andrew M. Waters, Alejandro Barrera, Annie Liu, Justine C. Rutter, Christian G. Cerda-Smith, Amy E. Stewart, Chao Wu, Merve Cakir, Cecilia B. Levandowski, David E. Kantrowitz, Shannon J. McCall, Mariaelena Pierobon, Emanuel F. Petricoin, J. Joshua Smith, Timothy E. Reddy, Channing J. Der, Dylan J. Taatjes, Kris C. Wood
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-14 (2024)
Abstract Acquired resistance remains a major challenge for therapies targeting oncogene activated pathways. KRAS is the most frequently mutated oncogene in human cancers, yet strategies targeting its downstream signaling kinases have failed to produc
Externí odkaz:
https://doaj.org/article/f640317b562445dfa0b4f3772b68e0d1
Autor:
Benjamin L. Allen, Kim Quach, Taylor Jones, Cecilia B. Levandowski, Christopher C. Ebmeier, Jonathan D. Rubin, Timothy Read, Robin D. Dowell, Alanna Schepartz, Dylan J. Taatjes
Publikováno v:
Cell Reports, Vol 39, Iss 1, Pp 110630- (2022)
Summary: DNA-binding transcription factors (TFs) remain challenging to target with molecular probes. Many TFs function in part through interaction with Mediator, a 26-subunit complex that controls RNA polymerase II activity genome-wide. We sought to
Externí odkaz:
https://doaj.org/article/778fb17bca8f4e708f1fcf23e5732ca5
Autor:
Daniel P. Nussbaum, Colin A. Martz, Andrew M. Waters, Alejandro Barrera, Justine C. Rutter, Christian G. Cerda-Smith, Amy E. Stewart, Chao Wu, Merve Cakir, Cecilia B. Levandowski, David E. Kantrowitz, Shannon J McCall, Mariaelena Pierobon, Emanuel F. Petricoin, J. Joshua Smith, Timothy E. Reddy, Channing J. Der, Dylan J. Taatjes, Kris C. Wood
Acquired resistance remains a major challenge for therapies targeting oncogene activated pathways. KRAS is the most frequently mutated oncogene in human cancers, yet strategies targeting its downstream signaling kinases have failed to produce durable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6680a174951b6e46872d5d13c55fc4f
https://doi.org/10.1101/2022.09.17.508384
https://doi.org/10.1101/2022.09.17.508384
Autor:
Jonathan D. Rubin, Rutendo F. Sigauke, Robin D. Dowell, Dylan J. Taatjes, Jessica T. Westfall, Zachary L. Maas, Cecilia B. Levandowski, Jacob T. Stanley
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Detecting changes in the activity of a transcription factor (TF) in response to a perturbation provides insights into the underlying cellular process. Transcription Factor Enrichment Analysis (TFEA) is a robust and reliable computational method that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d6ec6891fb256f2ed491a83d837202c
https://pubmed.ncbi.nlm.nih.gov/34079046
https://pubmed.ncbi.nlm.nih.gov/34079046
Autor:
Adrian TA Dominguez, Adreanna G. Real, Cecilia B. Levandowski, Matthew S. Lewis, Sarah Hartman, Betelehem Yacob, Stephen Smoots, Anna Schreiber, Jordi Lanis, Pragya Nepal, Jennifer Diamond, Chris Lieu, Wells Messersmith, Julie Lang, Todd Pitts
Publikováno v:
Cancer Research. 82:3509-3509
Pancreatic ductal adenocarcinoma (PDAC) shows little to no symptoms and is often detected at later stages which makes it difficult to treat resulting in a very low survival rate. PDAC is resistant to most chemotherapy mostly due to a high amount of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3048bbe183fa46a0c9a1c85d9a6e1665
https://doi.org/10.1158/1538-7445.am2022-3509
https://doi.org/10.1158/1538-7445.am2022-3509
Autor:
Rutendo F. Sigauke, Jessica T. Westfall, Zachary L. Maas, Dylan J. Taatjes, Robin D. Dowell, Jacob T. Stanley, Cecilia B. Levandowski, Jonathan D. Rubin
1AbstractDetecting differential activation of transcription factors (TFs) in response to perturbation provides insight into cellular processes. Transcription Factor Enrichment Analysis (TFEA) is a robust and reliable computational method that detects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f6d70cf9e322afec7179036698cbfb6
https://doi.org/10.1101/2020.01.25.919738
https://doi.org/10.1101/2020.01.25.919738
Autor:
Cecilia B. Levandowski, Sivapriya Ramamoorthy, Robin D. Dowell, T. Jones, Margaret Gruca, Dylan J. Taatjes
Publikováno v:
SSRN Electronic Journal.
The Δ40p53 isoform heterotetramerizes with WTp53 to regulate development, aging, and stress responses. How Δ40p53 alters WTp53 function remains enigmatic because their co-expression causes tetramer heterogeneity. We circumvented this issue with kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a44854c6c61d4af3eff60d9d832db512
https://doi.org/10.2139/ssrn.3624472
https://doi.org/10.2139/ssrn.3624472
Autor:
Robin D. Dowell, Taylor Jones, Margaret Gruca, Dylan J. Taatjes, Sivapriya Ramamoorthy, Cecilia B. Levandowski
Publikováno v:
PLoS Biology, Vol 19, Iss 8, p e3001364 (2021)
PLoS Biology
PLoS Biology
The naturally occurring Δ40p53 isoform heterotetramerizes with wild-type p53 (WTp53) to regulate development, aging, and stress responses. How Δ40p53 alters WTp53 function remains enigmatic because their co-expression causes tetramer heterogeneity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ece2e5619077f8638b9c0baccb87d0ef
https://doi.org/10.1371/journal.pbio.3001364
https://doi.org/10.1371/journal.pbio.3001364
Autor:
Cory Manly, William E. Brandenburg, Tom Califf, Cecilia B. Levandowski, William Brower Levandowski
Publikováno v:
Wilderness & Environmental Medicine. 28:127-138
Mountains are home to numerous organisms known to cause skin disease. Bites, stings, poisons, chemicals, toxins, trauma, and infections all contribute to this end. Numerous plants, animals, fungi, bacteria, viruses, and protozoa are responsible. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7fd81682ef3c4d39ef350c712724338
https://doi.org/10.1016/j.wem.2017.02.007
https://doi.org/10.1016/j.wem.2017.02.007