Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Cecilia A. O'Brien"'
Autor:
Denise Haslwanter, M. Eugenia Dieterle, Anna Z. Wec, Cecilia M. O’Brien, Mrunal Sakharkar, Catalina Florez, Karen Tong, C. Garrett Rappazzo, Gorka Lasso, Olivia Vergnolle, Ariel S. Wirchnianski, Robert H. Bortz, Ethan Laudermilch, J. Maximilian Fels, Amanda Mengotto, Ryan J. Malonis, George I. Georgiev, Jose A. Quiroz, Daniel Wrapp, Nianshuang Wang, Kathryn E. Dye, Jason Barnhill, John M. Dye, Jason S. McLellan, Johanna P. Daily, Jonathan R. Lai, Andrew S. Herbert, Laura M. Walker, Kartik Chandran, Rohit K. Jangra
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
The U.S. FDA has issued emergency use authorizations (EUAs) for multiple investigational monoclonal antibody (MAb) therapies for the treatment of mild to moderate COVID-19.
Externí odkaz:
https://doaj.org/article/679d11cbba69478ca30bdf9534e81939
Autor:
Lisa L. Hunter, Gordon P. Watt, Cecilia A. O'Brien, Rebecca M. Howell, John D. Boice, Laura Cervino, Meghan Woods, Marilyn Stovall, Eric J. Chow, Kathleen E. Malone, Judy Goldstein, Michele M. West, Xiaolin Liang, Lene Mellemkjӕr, Lawrence T. Dauer, Charles F. Lynch, Lauren E. Carlson, Emily S. Tonorezos, Roy E. Shore, Leslie Bernstein, Mark E. Robson, Rikke Langballe, Anne S. Reiner, Marinela Capanu, Anthony F. Yu, Jonine L. Bernstein, Irene Orlow, Susan A. Smith, Jennifer D. Brooks, Jørgen H. Olsen, Kristina M. Blackmore, Esther M. John, Rita E. Weathers, Irene Harris, Julia A. Knight, Elaine Ramos
Publikováno v:
JACC: CardioOncology
Background Radiation therapy (RT) for breast cancer increases risk of coronary artery disease (CAD). Women treated for left- vs right-sided breast cancer receive greater heart radiation exposure, which may further increase this risk. The risk of radi
Autor:
Eva Mittler, Anna Z. Wec, Janne Tynell, Pablo Guardado-Calvo, Julia Wigren-Byström, Laura C. Polanco, Cecilia M. O’Brien, Megan M. Slough, Dafna M. Abelson, Alexandra Serris, Mrunal Sakharkar, Gerard Pehau-Arnaudet, Russell R. Bakken, James C. Geoghegan, Rohit K. Jangra, Markus Keller, Larry Zeitlin, Olli Vapalahti, Rainer G. Ulrich, Zachary A. Bornholdt, Clas Ahlm, Felix A. Rey, John M. Dye, Steven B. Bradfute, Tomas Strandin, Andrew S. Herbert, Mattias N. E. Forsell, Laura M. Walker, Kartik Chandran
Publikováno v:
Science Translational Medicine
Science Translational Medicine, 2022, 14 (636), ⟨10.1126/scitranslmed.abl5399⟩
Sci Transl Med
Science Translational Medicine, 2022, 14 (636), ⟨10.1126/scitranslmed.abl5399⟩
Sci Transl Med
International audience; The rodent-borne hantavirus Puumala virus (PUUV) and related agents cause hemorrhagic fever with renal syndrome (HFRS) in humans. Other hantaviruses, including Andes virus (ANDV) and Sin Nombre virus, cause a distinct zoonotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33627d589b049bedaa9052abd9b3ea5f
https://hal-pasteur.archives-ouvertes.fr/pasteur-03902510
https://hal-pasteur.archives-ouvertes.fr/pasteur-03902510
Autor:
Rohit K. Jangra, J. Maximilian Fels, John M. Dye, Karen Tong, Olivia Vergnolle, Johanna P. Daily, Ryan J. Malonis, Jonathan R. Lai, M. Eugenia Dieterle, Ariel S. Wirchnianski, Andrew S. Herbert, Kartik Chandran, Denise Haslwanter, Jose A. Quiroz, Mrunal Sakharkar, C. Garrett Rappazzo, George I. Georgiev, Daniel Wrapp, Catalina Florez, Jason S. McLellan, Jason Barnhill, Anna Z. Wec, Robert H. Bortz, Laura M. Walker, Gorka Lasso, Ethan Laudermilch, Kathryn E Dye, Amanda Mengotto, Nianshuang Wang, Cecilia M. O’Brien
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
mBio
mBio
Most known SARS-CoV-2 neutralizing antibodies (nAbs), including those approved by the FDA for emergency use, inhibit viral infection by targeting the receptor-binding domain (RBD) of the spike (S) protein. Variants of concern (VOC) carrying mutations
Autor:
Jason S. McLellan, C. Garrett Rappazzo, James C. Geoghegan, Longping V. Tse, John M. Dye, James E. Voss, Dennis R. Burton, Jonathan P. Belk, Laura M. Walker, Linlin Yang, Yixuan J. Hou, Chengzi I. Kaku, Andrew S. Herbert, Mrunal Sakharkar, Ralph S. Baric, Laura M. Deveau, Trevor Scobey, David Nemazee, Thomas J. Yockachonis, Michael E. Brown, Daniel Wrapp, Bronwyn M. Gunn, Linghang Peng, Cecilia M. O’Brien, Michael B. Battles, Deli Huang, Lisa E. Gralinski
Publikováno v:
Science
Targeting sarbecoviruses As we continue to battle the COVID-19 pandemic, we must confront the possibility of new pathogenic coronaviruses emerging in humans in the future. With this in mind, Rappazzo et al. isolated antibodies from a survivor of the
Autor:
Chengzi I. Kaku, Longping V. Tse, Rappazzo Cg, James E. Voss, Andrew S. Herbert, Bronwyn M. Gunn, Dennis R. Burton, Michael E. Brown, Jason S. McLellan, Yockachonis Tj, Linghang Peng, Cecilia M. O’Brien, John M. Dye, Jonathan P. Belk, Laura M. Walker, Deli Huang, Trevor Scobey, Lisa E. Gralinski, Linlin Yang, Ralph S. Baric, Daniel Wrapp, Deveau Lm, James C. Geoghegan, Mrunal Sakharkar, David Nemazee, Michael B. Battles
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
The recurrent zoonotic spillover of coronaviruses (CoVs) into the human population underscores the need for broadly active countermeasures. Here, we employed a directed evolution approach to engineer three SARS-CoV-2 antibodies for enhanced neutraliz
Autor:
Akers Ks, Keersten M. Ricks, Andrew S. Herbert, Timothy D. Minogue, Jeffrey W. Koehler, Jay W. Hooper, Sara C. Johnston, Gibson Km, Kuehnert Pa, Delp Kl, Brett Beitzel, Kugelman, Cecilia M. O’Brien, Clements Tl, Charles J. Shoemaker, Jeffrey M. Smith, Ana I. Kuehne, John M. Dye, Coyne
COVID-19 presents herculean challenges to research and scientific communities for producing diagnostic and treatment solutions. Any return to normalcy requires rapid development of countermeasures, with animal models serving as a critical tool in tes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d923069056f1fecaf87aee7cf9da6187
https://doi.org/10.1101/2020.07.06.189803
https://doi.org/10.1101/2020.07.06.189803
Autor:
Anna Z. Wec, Daniel Wrapp, Andrew S. Herbert, Daniel Maurer, Denise Haslwanter, Mrunal Sakharkar, Rohit K. Jangra, M. Eugenia Dieterle, Asparouh Lilov, Deli Huang, Longping V. Tse, Nicole V. Johnson, Ching-Lin Hsieh, Nianshuang Wang, Juergen H. Nett, Elizabeth Champney, Irina Burnina, Michael Brown, Shu Lin, Melanie Sinclair, Carl Johnson, Sarat Pudi, Robert Bortz, Ariel S. Wirchnianski, Ethan Laudermilch, Catalina Florez, J. Maximilian Fels, Cecilia M. O’Brien, Barney S. Graham, David Nemazee, Dennis R. Burton, Ralph S. Baric, James E. Voss, Kartik Chandran, John M. Dye, Jason S. McLellan, Laura M. Walker
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 2
article-version (status) pre
article-version (number) 2
Broadly protective vaccines against known and pre-emergent coronaviruses are urgently needed. Critical to their development is a deeper understanding of cross-neutralizing antibody responses induced by natural human coronavirus (HCoV) infections. Her
Autor:
Laura M. Walker, Mrunal Sakharkar, Ching-Lin Hsieh, Kartik Chandran, Ethan Laudermilch, Ariel S. Wirchnianski, Barney S. Graham, Daniel P. Maurer, Deli Huang, Sarat Pudi, John M. Dye, Elizabeth Champney, Asparouh Lilov, James E. Voss, David Nemazee, Melanie Sinclair, Catalina Florez, Denise Haslwanter, Jason S. McLellan, M. Eugenia Dieterle, Dennis R. Burton, Andrew S. Herbert, Ralph S. Baric, Irina Burnina, Nicole V. Johnson, Anna Z. Wec, Longping V. Tse, Daniel Wrapp, Rohit K. Jangra, Nianshuang Wang, Cecilia M. O’Brien, Shu Lin, Juergen Hermann Nett, J. Maximilian Fels, Carl Hirschie Johnson, Michael G. Brown, Robert H. Bortz
Publikováno v:
Science (New York, N.y.)
Science
Science
Seeking broad protection As scientists develop therapeutic antibodies and vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the risk of emergent coronaviruses makes it important to also identify broadly protective antibod
Autor:
Laura I. Prugar, Stanford Schor, Shirit Einav, Steven De Jonghe, Jef Rozenski, Cecilia M. O’Brien, Randy Wouters, Jennifer M. Brannan, Rina Barouch-Bentov, Piet Herdewijn, John M. Dye, Szu-Yuan Pu
Publikováno v:
Journal of Medicinal Chemistry. 61:6178-6192
There is an urgent need for strategies to combat dengue and other emerging viral infections. We reported that cyclin G-associated kinase (GAK), a cellular regulator of the clathrin-associated host adaptor proteins AP-1 and AP-2, regulates intracellul