Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Cecilia, Pozzi"'
Autor:
Giusy Tassone, Samuele Maramai, Marco Paolino, Stefania Lamponi, Federica Poggialini, Elena Dreassi, Elena Petricci, Stefano Alcaro, Cecilia Pozzi, Isabella Romeo
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Bioconjugation is one of the most promising strategies to improve drug delivery, especially in cancer therapy. Biomolecules such as bile acids (BAs) have been intensively explored as carriers, due to their peculiar physicochemical properties
Externí odkaz:
https://doaj.org/article/1a4c84aa763544cdb95cf8741a3df437
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8279 (2024)
Glutaminyl-peptide cyclotransferases (QCs) convert the N-terminal glutamine or glutamate residues of protein and peptide substrates into pyroglutamate (pE) by releasing ammonia or a water molecule. The N-terminal pE modification protects peptides/pro
Externí odkaz:
https://doaj.org/article/9b8d5d15b9bd4b4d971b0bd4f9c4880c
Autor:
Luca Costantino, Stefania Ferrari, Matteo Santucci, Outi MH Salo-Ahen, Emanuele Carosati, Silvia Franchini, Angela Lauriola, Cecilia Pozzi, Matteo Trande, Gaia Gozzi, Puneet Saxena, Giuseppe Cannazza, Lorena Losi, Daniela Cardinale, Alberto Venturelli, Antonio Quotadamo, Pasquale Linciano, Lorenzo Tagliazucchi, Maria Gaetana Moschella, Remo Guerrini, Salvatore Pacifico, Rosaria Luciani, Filippo Genovese, Stefan Henrich, Silvia Alboni, Nuno Santarem, Anabela da Silva Cordeiro, Elisa Giovannetti, Godefridus J Peters, Paolo Pinton, Alessandro Rimessi, Gabriele Cruciani, Robert M Stroud, Rebecca C Wade, Stefano Mangani, Gaetano Marverti, Domenico D'Arca, Glauco Ponterini, Maria Paola Costi
Publikováno v:
eLife, Vol 11 (2022)
Drugs that target human thymidylate synthase (hTS), a dimeric enzyme, are widely used in anticancer therapy. However, treatment with classical substrate-site-directed TS inhibitors induces over-expression of this protein and development of drug resis
Externí odkaz:
https://doaj.org/article/6b5ed787a8314e518ea035b5e470ee7c
Autor:
Tommaso Palomba, Giusy Tassone, Carmine Vacca, Matteo Bartalucci, Aurora Valeri, Cecilia Pozzi, Simon Cross, Lydia Siragusa, Jenny Desantis
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 14218 (2022)
The field of targeted protein degradation, through the control of the ubiquitin–proteasome system (UPS), is progressing considerably; to exploit this new therapeutic modality, the proteolysis targeting chimera (PROTAC) technology was born. The oppo
Externí odkaz:
https://doaj.org/article/3746b5fdb19a430aa4718c71306cfa7d
Publikováno v:
Pharmaceuticals, Vol 15, Iss 11, p 1341 (2022)
Protozoan parasites are responsible for several harmful and widespread human diseases that cause high morbidity and mortality. Currently available treatments have serious limitations due to poor efficiency, strong adverse effects, and high cost. Henc
Externí odkaz:
https://doaj.org/article/0a1703002fc6475aa5cadd2be35ba060
Autor:
Giusy Tassone, Marco Mazzorana, Stefano Mangani, Elena Petricci, Elena Cini, Giuseppe Giannini, Cecilia Pozzi, Samuele Maramai
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 9458 (2022)
Heat shock protein 90 (Hsp90) is a ubiquitous molecular chaperone that stabilizes client proteins in a folded and functional state. It is composed of two identical and symmetrical subunits and each monomer consists of three domains, the N-terminal (N
Externí odkaz:
https://doaj.org/article/36a7d552437642ad946f7f7e91da1c5c
Autor:
Cecilia Pozzi, Anne Vanet, Valeria Francesconi, Lorenzo Tagliazucchi, Giusy Tassone, Alberto Venturelli, Francesca Spyrakis, Marco Mazzorana, Maria P. Costi, Michele Tonelli
Publikováno v:
Journal of Medicinal Chemistry. 66:3664-3702
Autor:
Matteo Santucci, Rosaria Luciani, Eleonora Gianquinto, Cecilia Pozzi, Flavio di Pisa, Lucia dello Iacono, Giacomo Landi, Lorenzo Tagliazucchi, Stefano Mangani, Francesca Spyrakis, Maria Paola Costi
Publikováno v:
Pharmaceuticals, Vol 14, Iss 12, p 1246 (2021)
Three open-source anti-kinetoplastid chemical boxes derived from a whole-cell phenotypic screening by GlaxoSmithKline (Tres Cantos Anti-Kinetoplastid Screening, TCAKS) were exploited for the discovery of a novel core structure inspiring new treatment
Externí odkaz:
https://doaj.org/article/dea8a1bafe16424b8a3fa4033cb94bf8
Autor:
Giusy Tassone, Giacomo Landi, Pasquale Linciano, Valeria Francesconi, Michele Tonelli, Lorenzo Tagliazucchi, Maria Paola Costi, Stefano Mangani, Cecilia Pozzi
Publikováno v:
Pharmaceuticals, Vol 14, Iss 7, p 636 (2021)
Trypanosoma and Leishmania parasites are the etiological agents of various threatening neglected tropical diseases (NTDs), including human African trypanosomiasis (HAT), Chagas disease, and various types of leishmaniasis. Recently, meaningful progres
Externí odkaz:
https://doaj.org/article/70e738fa89394bc7959ea50a78f26d41
Autor:
Pasquale Linciano, Alice Dawson, Ina Pöhner, David M. Costa, Monica S. Sá, Anabela Cordeiro-da-Silva, Rosaria Luciani, Sheraz Gul, Gesa Witt, Bernhard Ellinger, Maria Kuzikov, Philip Gribbon, Jeanette Reinshagen, Markus Wolf, Birte Behrens, Véronique Hannaert, Paul A. M. Michels, Erika Nerini, Cecilia Pozzi, Flavio di Pisa, Giacomo Landi, Nuno Santarem, Stefania Ferrari, Puneet Saxena, Sandra Lazzari, Giuseppe Cannazza, Lucio H. Freitas-Junior, Carolina B. Moraes, Bruno S. Pascoalino, Laura M. Alcântara, Claudia P. Bertolacini, Vanessa Fontana, Ulrike Wittig, Wolfgang Müller, Rebecca C. Wade, William N. Hunter, Stefano Mangani, Luca Costantino, Maria P. Costi
Publikováno v:
ACS Omega, Vol 2, Iss 9, Pp 5666-5683 (2017)
Externí odkaz:
https://doaj.org/article/5c64fcc1dcb6440098320d12bd53e394