In-depth analysis of transcriptomes in ovarian cortical follicles from children and adults reveals interfollicular heterogeneity

Autor: Ilmatar Rooda, Jasmin Hassan, Jie Hao, Magdalena Wagner, Elisabeth Moussaud-Lamodière, Kersti Jääger, Marjut Otala, Katri Knuus, Cecilia Lindskog, Kiriaki Papaikonomou, Sebastian Gidlöf, Cecilia Langenskiöld, Hartmut Vogt, Per Frisk, Johan Malmros, Timo Tuuri, Andres Salumets, Kirsi Jahnukainen, Agne Velthut-Meikas, Pauliina Damdimopoulou

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Abstract The ovarian cortical reserve of follicles is vital for fertility. Some medical treatments are toxic to follicles, leading to premature ovarian insufficiency. Ovarian tissue cryopreservation is an established method to preserve fertility in a

Externí odkaz: https://doaj.org/article/77fedca180d8474c9e1077ca6087555e

Spermatogonia Loss Correlates with LAMA 1 Expression in Human Prepubertal Testes Stored for Fertility Preservation

Autor: Magdalena Kurek, Elisabet Åkesson, Masahito Yoshihara, Elizabeth Oliver, Yanhua Cui, Martin Becker, João Pedro Alves-Lopes, Ragnar Bjarnason, Patrik Romerius, Mikael Sundin, Ulrika Norén Nyström, Cecilia Langenskiöld, Hartmut Vogt, Lars Henningsohn, Cecilia Petersen, Olle Söder, Jingtao Guo, Rod T. Mitchell, Kirsi Jahnukainen, Jan-Bernd Stukenborg

Publikováno v: Cells, Vol 10, Iss 2, p 241 (2021)

Fertility preservation for male childhood cancer survivors not yet capable of producing mature spermatozoa, relies on experimental approaches such as testicular explant culture. Although the first steps in somatic maturation can be observed in human

Externí odkaz: https://doaj.org/article/da13d3212ab546fc9dd2f8ed9f73592d

NOR-GRASPALL2016 (NCT03267030): Asparaginase Encapsulated in Erythrocytes (eryaspase) - a Promising Alternative to Peg-Asparaginase in Case of Hypersensitivity

Autor: Kjeld Schmiegelow, Sofie Gottschalk Højfeldt, Anne Kristine Lehmann, Line Stensig Lynggaard, Goda Vaitkeviciene, Cecilia Langenskiöld, Päivi M. Lähteenmäki, Kristi Lepik, Lisbeth Moeller, Birgitte Klug Albertsen

Publikováno v: Lynggaard, L S, Gottschalk Højfeldt, S, Møller, L N, Vaitkeviciene, G, Lepik, K, Cecilia, L, päivi, L, Lehmann, A K, Schmiegelow, K & Albertsen, BK 2020, ' NOR-GRASPALL2016 (NCT03267030): Asparaginase Encapsulated in Erythrocytes (eryaspase) – a Promising Alternative to Peg-Asparaginase in Case of Hypersensitivity ', Blood, vol. 136, no. Suppl 1, pp. 13-14 .
Aarhus University

Introduction: Asparaginase is an essential part of the treatment of acute lymphoblastic leukemia (ALL). Hypersensitivity occurred in 16.8% (clinical allergy (13.8%) or silent inactivation (3.0%)) of patients treated with pegylated asparaginase (PEG-a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbaceda14abe3257f810828e4b474407
https://doi.org/10.1182/blood-2020-139373

Spectrum of Atypical Clinical Presentations in Patients with Biallelic PRF1 Missense Mutations

Autor: Magnus Nordenskjöld, Cecilia Langenskiöld, Marie Meeths, Sule Unal, Yenan T. Bryceson, Zehra Fadoo, Bianca Tesi, João Pinho Silva, Jan-Inge Henter, Samuel C. C. Chiang, Rabia Muhammad Wali, Ayad Ahmed Hussein, Ramón Lecumberri, Dalia H. El-Ghoneimy

Publikováno v: Pediatric Blood & Cancer. 62:2094-2100

Background Perforin, encoded by PRF1, is a pore-forming protein crucial for lymphocyte cytotoxicity. Biallelic PRF1 nonsense mutations invariably result in early-onset hemophagocytic lymphohistiocytosis (HLH), termed familial HLH type 2 (FHL2). In co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c23e9df7807eb083cf80c1889e9b2729
https://doi.org/10.1002/pbc.25646

Comparison Of Primary Human Cytotoxic T-Cell And Natural Killer Cell Responses Reveal Similar Molecular Requirements For Lytic Granule Exocytosis But Differences In Cytokine Production

Autor: Ahmed Naqvi, Marianne Ifversen, Jan-Inge Henter, Jeanette Payne, Miriam Entesarian, Marie Meeths, Jakob Theorell, Ekrem Unal, Yenan T. Bryceson, Samuel C. C. Chiang, Kimberly Gilmour, Jacek Winiarski, Cecilia Langenskiöld, Antonio Pérez-Martínez, Magnus Sabel, Per Frisk, Maciej Machaczka, Sule Unal, Magnus Nordenskjöld, Hans-Gustaf Ljunggren, Monika Mastafa, Waleed Al-Herz

Cytotoxic lymphocytes, encompassing cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells, kill pathogen-infected, neoplastic, or certain hematopoietic cells through the release of perforin-containing lytic granules. In the present study, we f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1beb530946189b3af09975ce15d75fdd
http://hdl.handle.net/11655/13869