Antimicrobial peptides in frog poisons constitute a molecular toxin delivery system against predators

Autor: Constantijn Raaymakers, Elin Verbrugghe, Sophie Hernot, Tom Hellebuyck, Cecilia Betti, Cindy Peleman, Myriam Claeys, Wim Bert, Vicky Caveliers, Steven Ballet, An Martel, Frank Pasmans, Kim Roelants

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)

To avoid being eaten, poisonous prey animals must rely on fast passage of toxins across a predator’s oral tissue, a major barrier to large molecules. Here, Raaymakers et al. show that antimicrobial peptides co secreted with frog toxins enhance into

Externí odkaz: https://doaj.org/article/71406291176f47ba9bab737724a02083

Neurotensin Analogues Containing Cyclic Surrogates of Tyrosine at Position 11 Improve NTS2 Selectivity Leading to Analgesia without Hypotension and Hypothermia

Autor: Louis Gendron, Cecilia Betti, Magali Chartier, Simon Gonzalez, Steven Ballet, Jean-Michel Longpré, Florine Cavelier, Charlotte Martin, Dirk Tourwé, Emilie Eiselt, Philippe Sarret

Publikováno v: ACS Chemical Neuroscience
ACS Chemical Neuroscience, American Chemical Society (ACS), 2019, 10 (11), pp.4535-4544. ⟨10.1021/acschemneuro.9b00390⟩

Neurotensin (NT) exerts its analgesic effects through activation of the G protein-coupled receptors NTS1 and NTS2. This opioid-independent antinociception represents a potential alternative for pain management. While activation of NTS1 also induces a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cebd3f1e4ddab88c561248eb130fe079
https://hal.archives-ouvertes.fr/hal-02400886

Site-Specific Radioactive Labeling of Nanobodies

Autor: Maxine, Crauwels, Sam, Massa, Charlotte, Martin, Cecilia, Betti, Steven, Ballet, Nick, Devoogdt, Catarina, Xavier, Serge, Muyldermans

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1827

Single-domain antibody fragments, also called nanobodies (Nbs), are increasingly being used as targeting molecular tools for imaging and/or targeted radionuclide therapy. To translate these tools to the clinic, it is preferred to obtain a homogeneous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3ec70c17113c9608c2629596f7f3216b
https://pubmed.ncbi.nlm.nih.gov/30196514

Site-Specific Radioactive Labeling of Nanobodies

Autor: Maxine Crauwels, Steven Ballet, Serge Muyldermans, Sam Massa, Catarina Xavier, Charlotte Martin, Cecilia Betti, Nick Devoogdt

Publikováno v: Antibody Engineering ISBN: 9781493986477

Single-domain antibody fragments, also called nanobodies (Nbs), are increasingly being used as targeting molecular tools for imaging and/or targeted radionuclide therapy. To translate these tools to the clinic, it is preferred to obtain a homogeneous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c5ec99fed1b80be399f8b6f95998154
https://doi.org/10.1007/978-1-4939-8648-4_26

χ-Space Screening of Dermorphin-Based Tetrapeptides through Use of Constrained Arylazepinone and Quinolinone Scaffolds

Autor: Louis Gendron, Dirk Tourwé, Frédéric Bihel, Nga N. Chung, Peter W. Schiller, Olivier Van der Poorten, Cecilia Betti, Robin Van Den Hauwe, Karel Guillemyn, Emilie Eiselt, Steven Ballet, François Hallé, Philippe Sarret

Publikováno v: ACS Medicinal Chemistry Letters
ACS Medicinal Chemistry Letters, American Chemical Society, 2017, 8 (11), pp.1177-1182. ⟨10.1021/acsmedchemlett.7b00347⟩

Herein, the synthesis of novel conformationally constrained amino acids, 4-amino-8-bromo-2-benzazepin-3-one (8-Br-Aba), 3-amino-3,4-dihydroquinolin-2-one, and regioisomeric 4-amino-naphthoazepinones (1- and 2-Ana), is described. Introduction of these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb26d3a07e8388d155d1e134bca1b18
https://hal.archives-ouvertes.fr/hal-02368778