Single‐domain antibodies targeting antithrombin reduce bleeding in hemophilic mice with or without inhibitors

Autor: Elena Barbon, Gabriel Ayme, Amel Mohamadi, Jean‐François Ottavi, Charlotte Kawecki, Caterina Casari, Sebastien Verhenne, Solenne Marmier, Laetitia van Wittenberghe, Severine Charles, Fanny Collaud, Cecile V Denis, Olivier D Christophe, Federico Mingozzi, Peter J Lenting

Publikováno v: EMBO Molecular Medicine, Vol 12, Iss 4, Pp 1-18 (2020)

Abstract Novel therapies for hemophilia, including non‐factor replacement and in vivo gene therapy, are showing promising results in the clinic, including for patients having a history of inhibitor development. Here, we propose a novel therapeutic

Externí odkaz: https://doaj.org/article/4434607219fc41c0b6465b55049e9dff

Terminal platelet production is regulated by von Willebrand factor.

Autor: Sonia Poirault-Chassac, Kim Anh Nguyen, Audrey Pietrzyk, Caterina Casari, Agnes Veyradier, Cecile V Denis, Dominique Baruch

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e63810 (2013)

It is established that proplatelets are formed from mature megakaryocytes (MK) as intermediates before platelet production. Recently, the presence of proplatelets was described in blood incubated in static conditions. We have previously demonstrated

Externí odkaz: https://doaj.org/article/a773e7d01b874c5999caaac0e564a4e5

Efficacy of platelet-inspired hemostatic nanoparticles on bleeding in Von Willebrand disease murine models

Autor: Stéphanie Roullet, Norman Luc, Julie Rayes, Jean Solarz, Dante Disharoon, Andrew J Ditto, Emily Gahagan, Christa Pawlowski, Thibaud Sefiane, Frédéric Adam, Caterina Casari, Olivier D. Christophe, Michael A Bruckman, Peter J Lenting, Anirban Sen Gupta, Cecile V Denis

Publikováno v: Blood.

The lack of innovation in Von Willebrand disease (VWD) originates from many factors including the complexity and heterogeneity of the disease but also from a lack of recognition of the impact of the bleeding symptoms experienced by VWD patients. Rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::249de84cf089dcb567517a220c454c68
https://doi.org/10.1182/blood.2022018956

A thrombopoietin receptor agonist to rescue an unusual platelet transfusion-induced reaction in a p.V1316M-associated von Willebrand disease type 2B patient

Autor: Caterina Casari, Remi Favier, Paulette Legendre, Alexandre Kauskot, Frederic Adam, Veronique Picard, Peter J. Lenting, Cecile V. Denis, Valerie Proulle

Publikováno v: Therapeutic Advances in Hematology, Vol 13 (2022)
Therapeutic Advances in Hematology
Therapeutic Advances in Hematology, 2022, 13, pp.204062072210768. ⟨10.1177/20406207221076812⟩

This report describes the first case of splenic injury in a patient with p.V1316M-associated von Willebrand disease type 2B (VWD2B) with chronic thrombocytopenia, successfully treated with nonoperative management including von Willebrand factor (VWF)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b695a1d1903f85906d7bc4dc19173b
https://doi.org/10.1177/20406207221076812

Von Willebrand Factor Gene Variants Associate with Herpes simplex Encephalitis.

Autor: Nada Abdelmagid, Biborka Bereczky-Veress, Santosh Atanur, Alena Musilová, Václav Zídek, Laura Saba, Andreas Warnecke, Mohsen Khademi, Marie Studahl, Elisabeth Aurelius, Anders Hjalmarsson, Ana Garcia-Diaz, Cécile V Denis, Tomas Bergström, Birgit Sköldenberg, Ingrid Kockum, Timothy Aitman, Norbert Hübner, Tomas Olsson, Michal Pravenec, Margarita Diez

Publikováno v: PLoS ONE, Vol 11, Iss 5, p e0155832 (2016)

Herpes simplex encephalitis (HSE) is a rare complication of Herpes simplex virus type-1 infection. It results in severe parenchymal damage in the brain. Although viral latency in neurons is very common in the population, it remains unclear why certai

Externí odkaz: https://doaj.org/article/6a186948765c434db82250a5c6150623