Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Cecile T.J. Holweg"'
Autor:
Amisha V. Barochia, Elizabeth M. Gordon, Maryann Kaler, Rosemarie A. Cuento, Patricia Theard, Debbie M. Figueroa, Xianglan Yao, Nargues A. Weir, Maureen L. Sampson, Mario Stylianou, David F. Choy, Cecile T.J. Holweg, Alan T. Remaley, Stewart J. Levine
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 8, Pp 1713-1721 (2017)
Blood eosinophil counts and serum periostin levels are biomarkers of type 2 inflammation. Although serum levels of HDL and apoA-I have been associated with less severe airflow obstruction in asthma, it is not known whether serum lipids or lipoprotein
Externí odkaz:
https://doaj.org/article/e258bc5868a040d483df2edbffce33b4
Autor:
Diana Chang, Christian Hammer, Cecile T.J. Holweg, Suresh Selvaraj, Nisha Rathore, Mark I. McCarthy, Brian L. Yaspan, David F. Choy
Publikováno v:
Journal of Allergy and Clinical Immunology. 151:1351-1356
Chronic spontaneous urticaria (CSU) is a dermatologic condition that is characterized by spontaneous, pruritic hives and/or angioedema that persist for six weeks or longer with no identifiable trigger. Anti-histamines and second line therapies such a
Autor:
Jonathan Witonsky, Jennifer R. Elhawary, Lauren A. Millette, Cecile T.J. Holweg, Jinnie Ko, Pranil Raut, Luisa N. Borrell
Publikováno v:
The Journal of Allergy and Clinical Immunology: In Practice.
Autor:
Matthew C. Eastwood, John Busby, David J. Jackson, Ian D. Pavord, Catherine E. Hanratty, Ratko Djukanovic, Ashley Woodcock, Samantha Walker, Timothy C. Hardman, Joseph R. Arron, David F. Choy, Peter Bradding, Chris E. Brightling, Rekha Chaudhuri, Douglas Cowan, Adel H. Mansur, Stephen J. Fowler, Peter Howarth, James Lordan, Andrew Menzies-Gow, Timothy Harrison, Douglas S. Robinson, Cecile T.J. Holweg, John G. Matthews, Liam G. Heaney
Publikováno v:
Eastwood, M C, Busby, J, Jackson, D J, Pavord, I D, Hanratty, C E, Djukanovic, R, Woodcock, A, Walker, S, Hardman, T C, Arron, J R, Choy, D F, Bradding, P, Brightling, C E, Chaudhuri, R, Cowan, D, Mansur, A H, Fowler, S J, Howarth, P, Lordan, J, Menzies-Gow, A, Harrison, T, Robinson, D S, Holweg, C T J, Matthews, J G, Heaney, L G & RASPUK Investigators 2023, ' A randomized trial of a composite T2-biomarker strategy adjusting corticosteroid treatment in severe asthma: a post-hoc analysis by sex ', The Journal of Allergy and Clinical Immunology: In Practice, vol. 11, no. 4, pp. 1233-1242.e5 . https://doi.org/10.1016/j.jaip.2022.12.019
RASPUK Investigators 2023, ' A randomised trial of a T2-composite-biomarker strategy adjusting corticosteroidtreatment in severe asthma, a post-hoc analysis by sex ', The journal of allergy and clinical immunology. In practice . https://doi.org/10.1016/j.jaip.2022.12.019
RASPUK Investigators 2023, ' A randomised trial of a T2-composite-biomarker strategy adjusting corticosteroidtreatment in severe asthma, a post-hoc analysis by sex ', The journal of allergy and clinical immunology. In practice . https://doi.org/10.1016/j.jaip.2022.12.019
BackgroundApproximately 5% to 10% of patients with asthma have severe disease, with a consistent preponderance in females. Current asthma guidelines recommend stepwise treatment to achieve symptom control with no differential treatment considerations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2581de96dba8e402e322395e7e2048b7
https://pure.qub.ac.uk/en/publications/0e19d403-6512-483c-99ba-4c785bc87c1f
https://pure.qub.ac.uk/en/publications/0e19d403-6512-483c-99ba-4c785bc87c1f
Publikováno v:
Annals of Allergy, Asthma & Immunology. 127:223-231
Background The anti–immunoglobulin E therapy, omalizumab, improves asthma control and reduces exacerbations in patients with moderate-to-severe allergic asthma. However, it has been suggested that omalizumab should be reserved for highly allergic p
Autor:
P. J. Sterk, John H. Riley, Thomas Sandström, Anna Selby, Laurie Pahus, C. Auffray, Ioannis Pandis, Julie Corfield, R. Djukanovic, K. Sun, Massimo Caruso, Jørgen Vestbo, Matthew J. Loza, Andrew J. Simpson, Dominic Burg, I.M. Adcock, S. Bates, Scott Wagers, Ana R. Sousa, J. Corfield, Ariane H. Wagener, René Lutter, Barbro Dahlén, Ratko Djukanovic, G. Praticò, I. Pandis, N. Mores, G. Hedlin, Navin Rao, I. Horváth, Alexander Mazein, B. De Meulder, Richard G. Knowles, John-Olof Thörngren, Wolfgang Seibold, P H Howarth, Victoria M. Goss, Cristina Gómez, Clare S. Murray, Paul Brinkman, Ildiko Horvath, Anthony D. Postle, M. Caruso, Martina Gahlemann, M. Puig Valls, F.K. Chung, P. Montuschi, Dominick E. Shaw, Kai Sun, Aruna T. Bansal, Fahad Alahmadi, Amphun Chaiboonchoe, Graham Roberts, Kian Fan Chung, Yike Guo, H. Ahmed, Thomas Geiser, Klaus Bønnelykke, M. Miralpeix, Simone Hashimoto, Diane Lefaudeux, S.S. Wagers, D. Erzen, B. Thornton, Florian Singer, Louise Fleming, Stephen J. Fowler, Neil Fitch, P. Bakke, Craig E. Wheelock, Nadja Hawwa Vissing, Tim Higenbottam, Jamie Matthews, F. Singer, S.E. Dahlén, Sarah Masefield, Roelinde Middelveld, Jens M. Hohlfeld, Anthony V. D'Amico, Paul Skipp, W.M.C. van Aalderen, Alan J. Knox, Sven-Erik Dahlén, Andrew Bush, A.T. Bansal, Pieter-Paul Hekking, Joost Brandsma, Stewart Bates, L.J. Fleming, Norbert Krug, N. Krug, Magnus Ericsson, J. Riley, P. Powel, Jacek Musiał, Amanda Roberts, Peter J. Sterk, Ian M. Adcock, Pascal Chanez, Cecile T.J. Holweg, F. Baribaud, Stelios Pavlidis, Veit J. Erpenbeck, Z. Weiszhart, C.E. Wheelock, Ralf Sigmund, James P.R. Schofield, Alexander Manta, Andrea Meiser, Susan J. Wilson, Jeanette Bigler, G. Roberts, M. van Geest, Hans Bisgaard, Urs Frey, Michael Boedigheimer, Per Bakke, Chris Compton, Enrica Bucchioni, Paolo Montuschi, David Myles, E.H.D. Bel, Anna James, Elena Formaggio, Anthony Rowe, Dominic E. Shaw, J. Haughney, P. Chanez, A.R. Sousa, S.J. Fowler, K. Fichtner, B. Dahlèn
Publikováno v:
U-BIOPRED Study Group 2021, ' Medication adherence in patients with severe asthma prescribed oral corticosteroids in the U-BIOPRED cohort ', Chest . https://doi.org/10.1016/j.chest.2021.02.023
Alahmadi, Fahad H; Simpson, Andrew J; Gomez, Cristina; Ericsson, Magnus; Thörngren, John-Olof; Wheelock, Craig; Shaw, Dominic E; Fleming, Louise J; Roberts, Graham; Riley, John; Bates, Stewart; Sousa, Ana R; Knowles, Richard; Bansal, Aruna T; Corfield, Julie; Pandis, Ioannis; Sun, Kai; Bakke, Per S; Caruso, Massimo; Chanez, Pascal; ... (2021). Medication Adherence in Patients With Severe Asthma Prescribed Oral Corticosteroids in the U-BIOPRED Cohort. Chest, 160(1), pp. 53-64. Elsevier 10.1016/j.chest.2021.02.023
Chest
Chest, 2021, 160 (1), pp.53-64. ⟨10.1016/j.chest.2021.02.023⟩
Chest, 160(1), 53-64. American College of Chest Physicians
Alahmadi, Fahad H; Simpson, Andrew J; Gomez, Cristina; Ericsson, Magnus; Thörngren, John-Olof; Wheelock, Craig; Shaw, Dominic E; Fleming, Louise J; Roberts, Graham; Riley, John; Bates, Stewart; Sousa, Ana R; Knowles, Richard; Bansal, Aruna T; Corfield, Julie; Pandis, Ioannis; Sun, Kai; Bakke, Per S; Caruso, Massimo; Chanez, Pascal; ... (2021). Medication Adherence in Patients With Severe Asthma Prescribed Oral Corticosteroids in the U-BIOPRED Cohort. Chest, 160(1), pp. 53-64. Elsevier 10.1016/j.chest.2021.02.023
Chest
Chest, 2021, 160 (1), pp.53-64. ⟨10.1016/j.chest.2021.02.023⟩
Chest, 160(1), 53-64. American College of Chest Physicians
Background: Although estimates of suboptimal adherence to oral corticosteroids in asthma range from 30% to 50%, no ideal method for measurement exists; the impact of poor adherence in severe asthma is likely to be particularly high. Research Question
Autor:
David C. Jackson, Catherine E. Hanratty, Kian Fan Chung, John G. Matthews, Ratko Djukanovic, Maria Nunez, Robert Niven, Douglas S. Robinson, Liam G Heaney, Michelle Bourne, Catherine Borg, Clare Connolly, Mary Bellamy, Val Hudson, Gareth M. Davies, Christopher E. Brightling, Beverley Hargadon, Traceyanne Grandison, Ian M. Adcock, Sebastian L. Johnston, Rekha Chaudhuri, Geraldine Jones, James Lordan, Andrew Menzies-Gow, Adnam Azim, Dominic E. Shaw, John Busby, Ashley Woodcock, Freda Yang, Peter Bradding, Christopher Corrigan, David F. Choy, Cecile T.J. Holweg, Douglas C. Cowan, Paula McCourt, Tim Harrison, Peter H. Howarth, AH Mansur, Joel Solis, Avril Horn, Joseph R. Arron, Gabrielle Gainsborough, Sarah E Davies, Stephen J. Fowler, Roisin Stone, Timothy C. Hardman, Ian D. Pavord, Samantha Walker, Richard W. Costello, Katherine C. Smith
Publikováno v:
The Lancet. Respiratory Medicine
Heaney, L G, Busby, J, Hanratty, C E, Djukanovic, R, Woodcock, A, Walker, S M, Hardman, T C, Arron, J R, Choy, D F, Bradding, P, Brightling, C E, Chaudhuri, R, Cowan, D C, Mansur, A H, Fowler, S J, Niven, R M, Howarth, P H, Lordan, J L, Menzies-Gow, A, Harrison, T W, Robinson, D S, Holweg, C T J, Matthews, J G & Pavord, I D 2020, ' Composite type-2 biomarker strategy versus a symptom-risk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre, single-blind, parallel group, randomised controlled trial ', The Lancet Respiratory Medicine, vol. 9, no. 1, pp. 57-68 . https://doi.org/10.1016/S2213-2600(20)30397-0
Investigators for the MRC Refractory Asthma Stratification Programme 2020, ' Composite type-2 biomarker strategy versus a symptom-risk-based algorithm to adjust corticosteroid dose in patients with severe asthma : a multicentre, single-blind, parallel group, randomised controlled trial ', The Lancet. Respiratory medicine, vol. 9, no. 1, pp. 57-68 . https://doi.org/10.1016/S2213-2600(20)30397-0
Heaney, L G, Busby, J, Hanratty, C E, Djukanovic, R, Woodcock, A, Walker, S M, Hardman, T C, Arron, J R, Choy, D F, Bradding, P, Brightling, C E, Chaudhuri, R, Cowan, D C, Mansur, A H, Fowler, S J, Niven, R M, Howarth, P H, Lordan, J L, Menzies-Gow, A, Harrison, T W, Robinson, D S, Holweg, C T J, Matthews, J G & Pavord, I D 2020, ' Composite type-2 biomarker strategy versus a symptom-risk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre, single-blind, parallel group, randomised controlled trial ', The Lancet Respiratory Medicine, vol. 9, no. 1, pp. 57-68 . https://doi.org/10.1016/S2213-2600(20)30397-0
Investigators for the MRC Refractory Asthma Stratification Programme 2020, ' Composite type-2 biomarker strategy versus a symptom-risk-based algorithm to adjust corticosteroid dose in patients with severe asthma : a multicentre, single-blind, parallel group, randomised controlled trial ', The Lancet. Respiratory medicine, vol. 9, no. 1, pp. 57-68 . https://doi.org/10.1016/S2213-2600(20)30397-0
Background: Asthma treatment guidelines recommend increasing corticosteroid dose to control symptoms and reduce exacerbations. This approach is potentially flawed because symptomatic asthma can occur without corticosteroid responsive type-2 (T2)-driv
Autor:
Pranil Raut, Meng Chen, Cecile T.J. Holweg, Kirk V. Shepard, Ming Yang, Eugene Choo, Hooman Pazwash
Publikováno v:
Clinical and Experimental Allergy
Background Current biologic therapies target allergic, eosinophilic or type 2 inflammation phenotypic asthma. However, frequency and degree of overlap among these subtypes is unclear. Objective To characterize overlap among allergic, eosinophilic and
Autor:
Kathryn Mesh, Kun Peng, John G. Matthews, Prescott G. Woodruff, Wendy S. Putnam, Melissa Gonzalez Edick, Elliot Israel, Peter Bradding, Margaret Solon, Francis Abreu, Arnaud Bourdin, Kit Wong, Monet Howard, Monica Kraft, Cecile T.J. Holweg, Joseph R. Arron, Cary D. Austin, J. Mark FitzGerald, Gail M. Gauvreau, David F. Choy, Fang Cai, Ronald E. Ferrando, Lief Bjermer, Miriam Baca, Julie Olsson, Clavier Investigators, Kaharu Sumino
Publikováno v:
Clinical and Experimental Allergy
Clinical and Experimental Allergy, Wiley, In press, ⟨10.1111/cea.13731⟩
Clinical and Experimental Allergy, In press, ⟨10.1111/cea.13731⟩
Clinical and Experimental Allergy, Wiley, In press, ⟨10.1111/cea.13731⟩
Clinical and Experimental Allergy, In press, ⟨10.1111/cea.13731⟩
Background The anti-interleukin 13 (IL-13) monoclonal antibody lebrikizumab improves lung function in patients with moderate-to-severe uncontrolled asthma, but its effects on airway inflammation and remodelling are unknown. CLAVIER was designed to as
Factors affecting adherence with treatment advice in a clinical trial of patients with severe asthma
Autor:
James Lordan, Catherine E. Hanratty, Stephen J. Fowler, Robert Niven, Peter H. Howarth, Ian D. Pavord, Ratko Djukanovic, Douglas C. Cowan, Timothy C. Hardman, Douglas S. Robinson, Rekha Chaudhuri, David F. Choy, Joseph R. Arron, John Busby, Peter Bradding, Cecile T.J. Holweg, Christopher E. Brightling, Liam G Heaney, Samantha Walker, Andrew Menzies-Gow, Tim Harrison, AH Mansur, John G. Matthews, Ashley Woodcock
Publikováno v:
investigators for the MRC Refractory Asthma Stratification Program 2021, ' Factors affecting adherence with treatment advice in a clinical trial of patients with severe asthma ', The European respiratory journal . https://doi.org/10.1183/13993003.00768-2021
Busby, J, Matthews, J G, Chaudhuri, R, Pavord, I D, Hardman, T C, Arron, J R, Bradding, P, Brightling, C E, Choy, D F, Cowan, D C, Djukanovic, R, Hanratty, C E, Harrison, T W, Holweg, C T, Howarth, P H, Fowler, S J, Lordan, J L, Mansur, A H, Menzies-Gow, A, Niven, R M, Robinson, D S, Walker, S M, Woodcock, A & Heaney, L G 2022, ' Factors affecting adherence with treatment advice in a clinical trial of patients with severe asthma ', European Respiratory Journal, vol. 59, no. 4, 2100768 . https://doi.org/10.1183/13993003.00768-2021
Busby, J, Matthews, J G, Chaudhuri, R, Pavord, I D, Hardman, T C, Arron, J R, Bradding, P, Brightling, C E, Choy, D F, Cowan, D C, Djukanovic, R, Hanratty, C E, Harrison, T W, Holweg, C T, Howarth, P H, Fowler, S J, Lordan, J L, Mansur, A H, Menzies-Gow, A, Niven, R M, Robinson, D S, Walker, S M, Woodcock, A & Heaney, L G 2022, ' Factors affecting adherence with treatment advice in a clinical trial of patients with severe asthma ', European Respiratory Journal, vol. 59, no. 4, 2100768 . https://doi.org/10.1183/13993003.00768-2021
Background: understanding why patients with severe asthma do not follow healthcare provider (HCP) advice to adjust treatment is critical to achieving personalised disease management.Methods: we reviewed patient choice to follow HCP advice to adjust a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ffac3e57c1bd41f1d84d5c166a75da1
https://eprints.soton.ac.uk/452216/
https://eprints.soton.ac.uk/452216/