Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Cecile Pegurier"'
Autor:
Felix Häberlein, Enrico Mingardo, Nicole Merten, Nina-Katharina Schulze Köhling, Philip Reinoß, Katharina Simon, Anna Japp, Bhuvaneswari Nagarajan, Ramona Schrage, Cecile Pegurier, Michel Gillard, Kelly R. Monk, Benjamin Odermatt, Evi Kostenis, Jesus Gomeza
Publikováno v:
Cell chemical biology. 29(10)
Therapies that promote neuroprotection and axonal survival by enhancing myelin regeneration are an unmet need to prevent disability progression in multiple sclerosis. Numerous potentially beneficial compounds have originated from phenotypic screening
Autor:
Ledecq Marie, Stéphane Meunier, Benoit Mathieu, Laurent Provins, Christian Wolff, Sébastien Lengelé, Alain Wagner, Anne Frycia, Florence Lebon, Nathalie Bosman, Cecile Pegurier, Kashinath Dhurke, Ananda Kumar Kanduluru
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:3978-3982
A multi-disciplinary approach was used to identify the first pharmacophore model for KCC2 blockers: several physico-chemical studies such as XRD and NMR were combined to molecular modelling techniques, SAR analysis and synthesis of constrained analog
Autor:
Stéphane Meunier, Laurent Provins, Philippe Collart, Ananda Kumar Kanduluru, Christian Wolff, Marie-Laure Delporte, Alain Wagner, Nathalie Pacico, Sébastien Lengelé, Cecile Pegurier, Lakshmana Rao Vadali, Nathalie Bosman, Karine Leclercq
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2542-2545
The discovery and optimization of a novel class of selective submicromolar KCC2 blockers is described. Details of synthesis and SAR are given together with ADME properties of selected compounds. A methylsulfone residue on the R(1) phenyl group improv
Autor:
Stefan Svensson, Bengt Lindqvist, Patrick Roussel, Ulla Thornström, Mona Sydow-Bäckman, Graeme Dykes, Jonas Uppenberg, Cecile Pegurier, Katarina Beierlein, Markus Thor, Jessica Heidrich, Martin John Slater, Lena Jendeberg, Anna Lena Gustavsson
Publikováno v:
Karolinska Institutet
A series of 5-substituted 2-benzoylaminobenzoic acids has been synthesized and assayed for PPARalpha/gamma activity. Both dual activators and selective PPARgamma agonists have been identified. This class of compounds was shown to activate the PPARgam
Autor:
Patrick Pasau, Nathalie Van houtvin, Cecile Pegurier, Thierry Kogej, Frédéric Gilson, Marc Van Thuyne, Sabine Defays, Pierre Danhaive, Michel Gillard, Philippe Collart, BerendJan van Keulen
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(15)
The discovery and optimization of a novel class of potent CCR3 antagonists is described. Details of synthesis and SAR are given together with some ADME properties of selected compounds. An optimal balance between activities, physicochemical propertie
Autor:
Alexander Giannaras, Nathalie Van houtvin, Dorin Preda, Dong Zou, Maggi Burton, Frédéric Denonne, Patrick Pasau, Jean-Marie Nicolas, Alan J. Dipesa, Andrew Volosov, Sophie Binet, Philippe Collart, Seema Kumar, Sabine Defays, Maria Eckert, Cecile Pegurier, Beth Levine
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(12)
The synthesis and structure-activity relationships against the C3a receptor of a series of substituted aminopiperidine derivatives are reported. DMPK properties and functional activities of selected compounds are described. The compounds obtained are