Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Cecile King"'
Autor:
Mahdi Zeraati, Samuel E. Ross, Behnaz Aghaei, Alvaro González Rajal, Cecile King, Marcel E. Dinger
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102729- (2023)
Summary: Intercalated motifs or i-Motifs (iMs) are nucleic acid structures formed by cytosine-rich sequences, which may regulate cellular processes and have broad applications in nanotechnology due to their pH-dependent nature. We have developed an i
Externí odkaz:
https://doaj.org/article/f7398032010c49589dab5a1ca8c35193
Autor:
Harikrishnan Balachandran, Chansavath Phetsouphanh, David Agapiou, Anurag Adhikari, Chaturaka Rodrigo, Mohamed Hammoud, Lok Bahadur Shrestha, Elizabeth Keoshkerian, Money Gupta, Stuart Turville, Daniel Christ, Cecile King, Sarah C. Sasson, Adam Bartlett, Branka Grubor-Bauk, William Rawlinson, Anupriya Aggarwal, Alberto Ospina Stella, Vera Klemm, Michael M. Mina, Jeffrey J. Post, Bernard Hudson, Nicky Gilroy, Pam Konecny, Golo Ahlenstiel, Dominic E. Dwyer, Tania C. Sorrell, Anthony Kelleher, Nicodemus Tedla, Andrew R. Lloyd, Marianne Martinello, Rowena A. Bull
Publikováno v:
Cell Reports, Vol 38, Iss 6, Pp 110345- (2022)
Summary: Understanding the long-term maintenance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity is critical for predicting protection against reinfection. In an age- and gender-matched cohort of 24 participants, the associat
Externí odkaz:
https://doaj.org/article/d1686078a040413a867cbc08aa5e8b00
Autor:
Cecile King
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 1, Pp 100009- (2020)
T follicular helper (TFH) cells are associated with the development of both autoimmune disease and T cell malignancies. In this issue, Reighard et al.,1 describe the design of PD-L1 chimeric antigen receptor (CAR) NK cells that effectively target and
Externí odkaz:
https://doaj.org/article/aed9d61773c74c66881e164d6defb0b3
Autor:
Claudia Loetsch, Joanna Warren, Adrienne Laskowski, Rodrigo Vazquez-Lombardi, Christoph Jandl, David B. Langley, Daniel Christ, David R. Thorburn, David K. Ryugo, Jonathan Sprent, Marcel Batten, Cecile King
Publikováno v:
Cell Reports, Vol 21, Iss 6, Pp 1624-1638 (2017)
Summary: The archetypal T cell-dependent antigen is sheep red blood cells (SRBCs), which have defined much of what we know about humoral immunity. Early studies using solubilized or sonicated SRBCs argued that the intact structure of SRBCs was import
Externí odkaz:
https://doaj.org/article/9b78d4ab3122444eaffd0facbe60a14a
Autor:
Rodrigo Vazquez-Lombardi, Claudia Loetsch, Daniela Zinkl, Jennifer Jackson, Peter Schofield, Elissa K. Deenick, Cecile King, Tri Giang Phan, Kylie E. Webster, Jonathan Sprent, Daniel Christ
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Interleukin-2 (IL-2) is a T-cell proliferating factor used for cancer immunotherapy. Here, the authors develop a long-lived variant of IL-2 that, mutated in its binding domain, drives a much more potent tumour regression by depleting CD25+ CD4+regula
Externí odkaz:
https://doaj.org/article/5b8e946c736b4be78cfb86f8d067ec42
Autor:
Christoph Jandl, Sue M. Liu, Pablo F. Cañete, Joanna Warren, William E. Hughes, Alexis Vogelzang, Kylie Webster, Maria E. Craig, Gulbu Uzel, Alexander Dent, Polina Stepensky, Bärbel Keller, Klaus Warnatz, Jonathan Sprent, Cecile King
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
IL-21 is central to follicular helper T cell function and germinal centre responses. Here the authors show that IL-21 signalling directly inhibits T follicular regulatory cells by limiting Bcl-6-dependent IL-2 receptor expression.
Externí odkaz:
https://doaj.org/article/7d6cbfdd10b44261bcdec7f07420ffa0
Autor:
Amit Lalwani, Joanna Warren, David Liuwantara, Wayne J. Hawthorne, Philip J. O’Connell, Frank J. Gonzalez, Rebecca A. Stokes, Jennifer Chen, D. Ross Laybutt, Maria E. Craig, Michael M. Swarbrick, Cecile King, Jenny E. Gunton
Publikováno v:
Cell Reports, Vol 27, Iss 8, Pp 2370-2384.e6 (2019)
Summary: The development of autoimmune disease type 1 diabetes (T1D) is determined by both genetic background and environmental factors. Environmental triggers include RNA viruses, particularly coxsackievirus (CV), but how they induce T1D is not unde
Externí odkaz:
https://doaj.org/article/f99ed7866a664ac8bc67124c86dc4c4b
Publikováno v:
Frontiers in Immunology, Vol 9 (2019)
CD4+ T helper (Th) cells that express the gut homing chemokine receptor CCR9 are increased in the peripheral blood of patients with inflammatory bowel disease and Sjögren's syndrome and in the inflamed lesions of autoimmune diseases that affect the
Externí odkaz:
https://doaj.org/article/ee3e451b003d4f31aab46e0c0c29b7c7
Autor:
Jae-Ho Cho, Hee-Ok Kim, Young-Jun Ju, Yoon-Chul Kye, Gil-Woo Lee, Sung-Woo Lee, Cheol-Heui Yun, Nunzio Bottini, Kylie Webster, Christopher C. Goodnow, Charles D. Surh, Cecile King, Jonathan Sprent
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Naïve T cells establish self-tolerance via negative selection of cells with strong reactivity for self-peptide/MHC complexes, but undergo T-cell receptor (TCR) desensitisation when leaving the thymus. Here, Choet al.show that TCR desensitisation cor
Externí odkaz:
https://doaj.org/article/78f7f7ad99d8416b980d0d865134abd4
Autor:
Karlo D T Natividad, Simon R Junankar, Norhanani Mohd Redzwan, Radhika Nair, Rushika C Wirasinha, Cecile King, Robert Brink, Alexander Swarbrick, Marcel Batten
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57469 (2013)
Interleukin-27 (IL-27) is a pleiotropic cytokine but its immunosuppressive effects predominate during many in vivo immunological challenges. Despite this, evidence from tumor cell line transfer models suggested that IL-27 could promote immune respons
Externí odkaz:
https://doaj.org/article/5013b632422a4d79b8f418f45485d116