Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Cecile A. Geuijen"'
Autor:
Romel Somwar, Alexander Drilon, Marc Ladanyi, Eileen M. O'Reilly, Elisa de Stanchina, Ernesto Wasserman, Jeroen J. Lammerts van Bueren, Ron C.J. Schackmann, Cecile A.W. Geuijen, Marie N. O'Connor, Jim Ford, Jean Torrisi, Thrusha Chauhan, Sara H. Shameem, Morana Vojnic, Allan J.W. Lui, Marissa S. Mattar, Whitney J. Sisso, Inna Khodos, Madelyn Espinosa-Cotton, Igor Odintsov, Alison M. Schram
Supplementary Figure from Zenocutuzumab, a HER2xHER3 Bispecific Antibody, Is Effective Therapy for Tumors Driven by NRG1 Gene Rearrangements
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957edba211dae8e33116bb0bbf5e53e7
https://doi.org/10.1158/2159-8290.22541186.v1
https://doi.org/10.1158/2159-8290.22541186.v1
Autor:
Romel Somwar, Alexander Drilon, Marc Ladanyi, Eileen M. O'Reilly, Elisa de Stanchina, Ernesto Wasserman, Jeroen J. Lammerts van Bueren, Ron C.J. Schackmann, Cecile A.W. Geuijen, Marie N. O'Connor, Jim Ford, Jean Torrisi, Thrusha Chauhan, Sara H. Shameem, Morana Vojnic, Allan J.W. Lui, Marissa S. Mattar, Whitney J. Sisso, Inna Khodos, Madelyn Espinosa-Cotton, Igor Odintsov, Alison M. Schram
NRG1 rearrangements are recurrent oncogenic drivers in solid tumors. NRG1 binds to HER3, leading to heterodimerization with other HER/ERBB kinases, increased downstream signaling, and tumorigenesis. Targeting ERBBs, therefore, represents a therapeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ad90ec0c5517efbc60698dfdb31aea
https://doi.org/10.1158/2159-8290.c.6549563.v1
https://doi.org/10.1158/2159-8290.c.6549563.v1
Autor:
Alison M. Schram, Igor Odintsov, Madelyn Espinosa-Cotton, Inna Khodos, Whitney J. Sisso, Marissa S. Mattar, Allan J.W. Lui, Morana Vojnic, Sara H. Shameem, Thrusha Chauhan, Jean Torrisi, Jim Ford, Marie N. O'Connor, Cecile A.W. Geuijen, Ron C.J. Schackmann, Jeroen J. Lammerts van Bueren, Ernesto Wasserman, Elisa de Stanchina, Eileen M. O'Reilly, Marc Ladanyi, Alexander Drilon, Romel Somwar
Publikováno v:
Cancer Discov
NRG1 rearrangements are recurrent oncogenic drivers in solid tumors. NRG1 binds to HER3, leading to heterodimerization with other HER/ERBB kinases, increased downstream signaling, and tumorigenesis. Targeting ERBBs, therefore, represents a therapeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95151a78f3149678f1573205c587eb3
https://doi.org/10.1158/2159-8290.cd-21-1119
https://doi.org/10.1158/2159-8290.cd-21-1119
Autor:
David J. de Gorter, Marie O'Connor, Alexandre Deshiere, Martijn van Rosmalen, Szabolcs Fatrai, Jeroen Lammerts van Bueren, Cecile A. Geuijen
Publikováno v:
Cancer Research. 82:336-336
Introduction: MCLA-129 is an ADCC-enhanced IgG1 bispecific antibody that targets epidermal growth factor receptor (EGFR) and c-MET. The HGF/c-MET pathway is frequently upregulated in tumors that are resistant to EGFR tyrosine kinase inhibitors (TKIs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca9dc8bb44c6dfd7ee67bd1d5c334ea3
https://doi.org/10.1158/1538-7445.am2022-336
https://doi.org/10.1158/1538-7445.am2022-336
Autor:
Maria van Gurp, Marie-Paule Sory, Cecile C.A.W. Geuijen, Wim Declercq, Geertrui Denecker, Guy R. Cornelis, Anne Boland, Peter Vandenabeele, Rachid Benabdillah
Publikováno v:
The Journal of Biological Chemistry. 276(23):19706-19714
Yersinia enterocolitica induces apoptosis in macrophages by injecting the plasmid-encoded YopP (YopJ in other Yersinia species). Recently it was reported that YopP/J is a member of an ubiquitin-like protein cysteine protease family and that the catal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0de90e5ca464087f149f537516e757fe
https://doi.org/10.1074/jbc.M101573200
https://doi.org/10.1074/jbc.M101573200
Autor:
Anne Boland, Guy R. Cornelis, Maite Iriarte, Isabelle Stainier, Marie-Paule Sory, Aoife Boyd, Cecile C.A.W. Geuijen, Cécile Neyt
Publikováno v:
ResearcherID
Publons
Microbiology and molecular biology reviews : MMBR, Vol. 62, no. 4, p. 1315-52 (1998)
Publons
Microbiology and molecular biology reviews : MMBR, Vol. 62, no. 4, p. 1315-52 (1998)
SUMMARY The 70-kb virulence plasmid enables Yersinia spp. (Yersinia pestis, Y. pseudotuberculosis, and Y. enterocolitica) to survive and multiply in the lymphoid tissues of their host. It encodes the Yop virulon, an integrated system allowing extrace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ed67e553727f19a5a426f8dfb6e2a3
https://doi.org/10.1128/mmbr.62.4.1315-1352.1998
https://doi.org/10.1128/mmbr.62.4.1315-1352.1998
Publikováno v:
Methods in Molecular Biology ISBN: 9781603273091
The discovery of novel target antigens for antibody-based immunotherapy is still a major challenge. Antibody phage display is one of the technologies that is widely applied for the identification of novel cell surface molecules on intact eukaryotic c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f12ab54de4daefa5b04d419fbe4155b1
https://doi.org/10.1007/978-1-60327-310-7_11
https://doi.org/10.1007/978-1-60327-310-7_11
Publikováno v:
Fair Disclosure Wire (Quarterly Earnings Reports). 10/26/2022.
Autor:
Romel Somwar, Allan J.W. Lui, Alison M. Schram, Marissa Mattar, Marc Ladanyi, Cecile Geuijen, Ron C. J. Schackmann, Igor Odintsov, Elisa de Stanchina, Jeroen J. Lammerts van Bueren, Madelyn Espinosa-Cotton, Inna Khodos
Publikováno v:
Cancer Research. 81:956-956
Fusions involving the neuregulin 1 gene (NRG1) occur at low frequency in pancreatic, lung, and other cancers. NRG1 fusion oncoproteins bind to HER3, leading to heterodimerization with HER2 and potent activation of downstream signaling mainly via the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60f99fd2a1cd8f4103a470ad76ec343e
https://doi.org/10.1158/1538-7445.am2021-956
https://doi.org/10.1158/1538-7445.am2021-956
Autor:
Qingyu Shu, Liang Deng, Rinse Klooster, Wenxin Xu, Cecile Geuijen, John de Kruif, Li Mao, Wei Liu, Martijn van Rosmalen, Mark Throsby, Tristan Gallenne, David J. de Gorter, Mario Di Matteo, Alexandre Deshiere, Christian Wohn, Massimiliano Mazzone, Berina Eppink
Publikováno v:
Cancer Research. 81:952-952
MCLA-129 is an ADCC-enhanced common light chain bispecific human IgG1 Biclonics® antibody specifically targeting the receptor tyrosine kinases EGFR and c-MET. It inhibits activation and downstream signaling of EGFR and c-MET induced by their respect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02db516a6d3a502f8247e3d00df0acc7
https://doi.org/10.1158/1538-7445.am2021-952
https://doi.org/10.1158/1538-7445.am2021-952