Altered memory CCR6+ Th17-polarised T-cell function and biology in people with HIV under successful antiretroviral therapy and HIV elite controllersResearch in context

Autor: Alexis Yero, Jean-Philippe Goulet, Tao Shi, Cecilia T. Costiniuk, Jean-Pierre Routy, Cecile Tremblay, Ralph-Sydney Mboumba Bouassa, Yulia Alexandrova, Amélie Pagliuzza, Nicolas Chomont, Petronela Ancuta, Mohammad-Ali Jenabian

Publikováno v: EBioMedicine, Vol 107, Iss , Pp 105274- (2024)

Summary: Background: Despite successful antiretroviral therapy (ART), frequencies and immunological functions of memory CCR6+ Th17-polarised CD4+ T-cells are not fully restored in people with HIV (PWH). Moreover, long-lived Th17 cells contribute to H

Externí odkaz: https://doaj.org/article/ca111586e7a54db389f6a611caef3faa

The Role of Phylogenetics in Unravelling Patterns of HIV Transmission towards Epidemic Control: The Quebec Experience (2002–2020)

Autor: Bluma G. Brenner, Ruxandra-Ilinca Ibanescu, Nathan Osman, Ernesto Cuadra-Foy, Maureen Oliveira, Antoine Chaillon, David Stephens, Isabelle Hardy, Jean-Pierre Routy, Réjean Thomas, Jean-Guy Baril, Roger Leblanc, Cecile Tremblay, Michel Roger, The Montreal Primary HIV Infection (PHI) Cohort Study Group

Publikováno v: Viruses, Vol 13, Iss 8, p 1643 (2021)

Phylogenetics has been advanced as a structural framework to infer evolving trends in the regional spread of HIV-1 and guide public health interventions. In Quebec, molecular network analyses tracked HIV transmission dynamics from 2002–2020 using M

Externí odkaz: https://doaj.org/article/ab4c0bb006b043ad801e294b6ba4e7c7

Long-term safety and efficacy of emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV-1 pre-exposure prophylaxis: week 96 results from a randomised, double-blind, placebo-controlled, phase 3 trial

Autor: Onyema Ogbuagu, Peter J Ruane, Daniel Podzamczer, Laura C Salazar, Keith Henry, David M Asmuth, David Wohl, Richard Gilson, Yongwu Shao, Ramin Ebrahimi, Stephanie Cox, Alexander Kintu, Christoph Carter, Moupali Das, Jared M Baeten, Diana M Brainard, Gary Whitlock, Jason M Brunetta, Gitte Kronborg, Christoph D Spinner, Andrea Antinori, Vanessa Apea, David Asmuth, Ann Avery, Paul Benson, Colm Bergin, Mezgebe Berhe, Indira Brar, Cynthia Brinson, Jason Brunetta, Jeffrey Burack, Thomas Campbell, Michelle Cespedes, Amanda Clarke, Megan Coleman, Josep Coll, Manuel Crespo Casal, Catherine Creticos, Gordon Crofoot, Frederick Cruickshank, Eric Cua, Eric Daar, Joseph de Wet, Edwin DeJesus, Jorge Del Romero Guerrero, William Dinges, Susanne Doblecki-Lewis, Taylor Donovan, Olamide Dosekun, Jason Flamm, Joel Gallant, Jan Gerstoft, Jay Gladstein, Robert Grant, Robert Grossberg, Bernhard Haas, Jason Halperin, W. David Hardy, Charles Hare, Shawn Hassler, Richard Hengel, William Henry, Theo Hodge, Sybil Hosek, Christopher Hurt, Michelle Iandiorio, Heiko Jessen, Stephen Kegg, Gabriele Knecht, Ivanka Krznaric, Anthony LaMarca, Carsten Schade Larsen, Olav Ditlevsen Larsen, Adriano Lazzarin, Clifford Leen, Christopher Lucasti, Patrick Mallon, Sharon Mannheimer, Martin Markowitz, Claudia Martorell, Kenneth Mayer, Anthony Mills, Jean-Michel Molina, Sheldon Morris, Karam Mounzer, Nneka Nwokolo, Olayemi Osiyemi, Andrew Petroll, Patrick Philibert, John Phoenix, Gilles Pialoux, Frank Post, Maria Prins, Moti Ramgopal, Bruce Rashbaum, Iain Reeves, Gary Richmond, Armin Rieger, Peter Ruane, Laura Salazar, Anthony Scarsella, Gabriel Schembri, Mia Scott, Peter Shalit, Gary Sinclair, Magdalena Sobieszczyk, Christoph Spinner, Jeffrey Stephens, Jason Szabo, Stephen Taylor, Melanie Thompson, Cecile Tremblay, Benoit Trottier, Gene Voskuhl, Barbara Wade, Kimberly Workowski, Sigal Yawetz, Benjamin Young

Publikováno v: The Lancet HIV, 8(7), e397-e407. Elsevier Limited
DISCOVER study team 2021, ' Long-term safety and efficacy of emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV-1 pre-exposure prophylaxis : week 96 results from a randomised, double-blind, placebo-controlled, phase 3 trial ', The Lancet HIV, vol. 8, no. 7, pp. e397-e407 . https://doi.org/10.1016/S2352-3018(21)00071-0

Summary Background In DISCOVER, a multinational, randomised controlled trial, emtricitabine and tenofovir alafenamide compared with emtricitabine and tenofovir disoproxil fumarate showed non-inferior efficacy for HIV prevention and improved bone mine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::303b5922ad83d78a448781b8c096428c
https://doi.org/10.1016/s2352-3018(21)00071-0

Early Initiation Rather Than Prolonged Duration of Antiretroviral Therapy in HIV Infection Contributes to the Normalization of CD8 T-Cell Counts

Autor: Wei, Cao, Vikram, Mehraj, Benoit, Trottier, Jean-Guy, Baril, Roger, Leblanc, Bertrand, Lebouche, Joseph, Cox, Cecile, Tremblay, Wei, Lu, Joel, Singer, Taisheng, Li, Jean-Pierre, Routy, S, Vézina, L, Charest, M, Milne, E, Huchet, S, Lavoie, J, Friedman, M, Duchastel, F, Villielm, P, Côté, M, Potter, B, Lessard, M A, Charron, S, Dufresne, M E, Turgeon, D, Rouleau, L, Labrecque, C, Fortin, A, de Pokomandy, V, Hal-Gagné, M, Munoz, B, Deligne, V, Martel-Laferrière, N, Gilmore, M, Fletcher, J, Szabo

Publikováno v: Clinical Infectious Diseases. 62:250-257

Background. CD8 T-cell counts remain elevated in human immunodeficiency virus (HIV) infection even after long-term antiretroviral therapy (ART), which is associated with an increased risk of non–AIDS-related events. We assessed the impact of ART in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47287acabf10adebe61d6853f893afd6
https://doi.org/10.1093/cid/civ809

Decreased Levels of Circulating IL-21 in HIV-Infected AIDS Patients Correlation with CD4T-Cell Counts.

Autor: Alexandre Iannello, Cecile Tremblay, Jean-Pierre Routy, Mohamed-Rachid Boulassel, Emil Toma, Ali Ahmad

Publikováno v: Viral Immunology; Sep2008, Vol. 21 Issue 3, p385-388, 4p