One-step assembly of large CRISPR arrays enables multi-functional targeting and reveals constraints on array design

Autor: Denny, Albert J. Keung, Cecil Td, Rebecca A. Slotkowski, Ryan T. Leenay, Chunyu Liao, Chase L. Beisel, Fani Ttofali

SUMMARYCRISPR-Cas systems inherently multiplex through their CRISPR arrays--whether to confer immunity against multiple invaders or by mediating multi-target editing, regulation, imaging, and sensing. However, arrays remain difficult to generate due

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Targeted Genetic Sequencing Analysis of 223 Cases of Pseudomyxoma Peritonei Treated by Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Shows Survival Related to GNAS and KRAS Status.

Autor: Gibson J; Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.; Bio-R Bioinformatics Research Facility, Faculty of Medicine, University of Southampton, Southampton, UK., Pengelly RJ; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK., Mirandari A; Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK., Boukas K; Wessex Investigational Sciences Hub, Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK., Stanford S; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Basingstoke, UK., Cecil TD; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Basingstoke, UK., Mohamed F; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Basingstoke, UK., Dayal SP; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Basingstoke, UK., Tzivanakis A; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Basingstoke, UK., Moran BJ; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Basingstoke, UK., Mirnezami A; Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK., Carr NJ; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK., Ennis S; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.

Publikováno v: Cancer medicine [Cancer Med] 2024 Oct; Vol. 13 (20), pp. e70340.

Managing Recurrent Pseudomyxoma Peritonei in 430 Patients After Complete Cytoreduction and HIPEC: A Dilemma for Patients and Surgeons.

Autor: Ahmadi N; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Basingstoke, UK.; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Basingstoke, UK., Kostadinov D, Sakata S; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Basingstoke, UK.; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Basingstoke, UK., Ball WR; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Basingstoke, UK.; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Basingstoke, UK., Gandhi J; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Basingstoke, UK.; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Basingstoke, UK., Carr NJ; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Basingstoke, UK.; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Basingstoke, UK., Tzivanakis A; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Basingstoke, UK.; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Basingstoke, UK., Dayal SP; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Basingstoke, UK.; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Basingstoke, UK., Mohamed F; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Basingstoke, UK.; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Basingstoke, UK., Cecil TD; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Basingstoke, UK.; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Basingstoke, UK., Moran BJ; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Basingstoke, UK. Moran820@btinternet.com.; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Basingstoke, UK. Moran820@btinternet.com.

Publikováno v: Annals of surgical oncology [Ann Surg Oncol] 2021 Nov; Vol. 28 (12), pp. 7809-7820. Date of Electronic Publication: 2021 May 26.

Patients undergoing cytoreductive surgery for peritoneal malignancy of appendiceal origin should be consented for umbilical excision as 30% have umbilical infiltration.

Autor: Sakata S; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Hampshire Hospitals National Health Service Foundation Trust, Basingstoke, Hampshire, UK., Tan TG; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Hampshire Hospitals National Health Service Foundation Trust, Basingstoke, Hampshire, UK., Kostadinov D; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Hampshire Hospitals National Health Service Foundation Trust, Basingstoke, Hampshire, UK., Ahmadi N; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Hampshire Hospitals National Health Service Foundation Trust, Basingstoke, Hampshire, UK., Dayal SP; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Hampshire Hospitals National Health Service Foundation Trust, Basingstoke, Hampshire, UK., Tzivanakis A; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Hampshire Hospitals National Health Service Foundation Trust, Basingstoke, Hampshire, UK., Mohamed F; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Hampshire Hospitals National Health Service Foundation Trust, Basingstoke, Hampshire, UK., Carr NJ; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Hampshire Hospitals National Health Service Foundation Trust, Basingstoke, Hampshire, UK., Cecil TD; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Hampshire Hospitals National Health Service Foundation Trust, Basingstoke, Hampshire, UK., Moran BJ; Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Hampshire Hospitals National Health Service Foundation Trust, Basingstoke, Hampshire, UK.

Publikováno v: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland [Colorectal Dis] 2021 May; Vol. 23 (5), pp. 1153-1157. Date of Electronic Publication: 2021 Feb 19.