Zobrazeno 1 - 10 of 56 pro vyhledávání: '"Cecil H. Robinson"'
1
Aromatase: Mechanism and Inhibition
Autor: Philip A. Cole, Cecil H. Robinson
Publikováno v: Molecular Structure and Biological Activity of Steroids ISBN: 9781351074803
Molecular Structure and Biological Activity of Steroids
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd2506bd5ed588b832c6bc9b373904c5
https://doi.org/10.1201/9781351074803-6
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2
Novel 10β-aziridinyl steroids; inhibitors of aromatase
Autor: J. V. Silverton, Cecil H. Robinson, Elam Safi, Vincent C. O. Njar
Publikováno v: J. Chem. Soc., Perkin Trans. 1. :1161-1168
The novel 10β-aziridinylestr-4-ene-3,17-diones 17 and 18 and the corresponding 10β-aziridinyl-β-hydroxyestr-4-en-3-ones 19 and 20 have been synthesized from the 19-oximino-19-methyl intermediate 12b. The key reaction was the conversion of the 19-o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52d190cf804d1b18e3544e3439c35e9f
https://doi.org/10.1039/p19930001161
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3
ChemInform Abstract: Novel 10β-Aziridinyl Steroids: Inhibitors of Aromatase
Autor: Vincent C. O. Njar, J. V. Silverton, Cecil H. Robinson, Elam Safi
Publikováno v: ChemInform. 24
The novel 10β-aziridinylestr-4-ene-3,17-diones 17 and 18 and the corresponding 10β-aziridinyl-β-hydroxyestr-4-en-3-ones 19 and 20 have been synthesized from the 19-oximino-19-methyl intermediate 12b. The key reaction was the conversion of the 19-o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0727ea4307f6ae9ffdf2fe1be8ba55d
https://doi.org/10.1002/chin.199337284
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4
ChemInform Abstract: Synthesis of 6α,7α- and 6β,7β-Aziridinoandrost-4- ene-3,17-diones and Related Compounds: Potential Aromatase Inhibitors
Autor: Vincent C. O. Njar, Cecil H. Robinson, Rolf W. Hartmann
Publikováno v: ChemInform. 26
The stereospecific synthesis of the novel 6β,7β- and 6α, 7α-aziridinoandrost-4-ene-3,17-dione 21 and 23 has been accomplished by treatment of vicinal azidohydrins 19 and 20 respectively with triphenylphosphane. Several related compounds (fused st
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::940b37ec6cfe798e121a788318ce3e40
https://doi.org/10.1002/chin.199533220
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6
Lanosterol 14 alpha-demethylase (P45014DM): effects of P45014DM inhibitors on sterol biosynthesis downstream of lanosterol
Autor: Cecil H. Robinson, Elam Safi, Himanshu Patel, Stephen F. Tuck
Publikováno v: Journal of Lipid Research, Vol 32, Iss 6, Pp 893-902 (1991)
Lanosterol 14 alpha-demethylase (P45014DM) is the cytochrome P450 enzyme complex responsible for an early step in cholesterol biosynthesis, namely the 14 alpha-demethylation of lanosterol. We have synthesized a novel series of steroidal substrate ana
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6869418cdf384be45135658933ffeaa3
https://doi.org/10.1016/s0022-2275(20)41987-x
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7
Inhibition of human placental aromatase by novel homologated 19-oxiranyl and 19-thiiranyl steroids
Autor: James T. Kellis, Larry E. Vickery, Wayne E. Childers, James V. Silverton, Cecil H. Robinson
Publikováno v: Journal of Medicinal Chemistry. 34:1344-1349
Novel homologated 19-oxiranyl- and 9-thiiranylandrost-4-ene-3,17-diones (8a,b and 9a,b, respectively) have been synthesized. The configuration and conformation of compound 8a have been established by X-ray crystallographic analysis. All four compound
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb2296489f976667d419e7365c501c3
https://doi.org/10.1021/jm00108a016
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8
Assessment of the active-site requirements of lanosterol 14.alpha.-demethylase: evaluation of novel substrate analogs as competitive inhibitors
Autor: Stephen F. Tuck, James V. Silverton, Cecil H. Robinson
Publikováno v: The Journal of Organic Chemistry. 56:1260-1266
A partir d'3β-acetate de lanost-7-ene-3β,30-diol, synthese de 14α-allyl, 14α-propyl, 14α-vinyl, 14α-ethyl-4,4-dimethyl-5α-cholest-7-en-3β-ol et de 30-thiiran-2-yl, 30-oxiran-2-yl-lanost-7-en-3β-ol. Etude de leur activite inhibitrice de la la
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1bebfd62fa7064f9e319e0aab69c924
https://doi.org/10.1021/jo00003a059
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9
Mechanism and inhibition of cytochrome P-450 aromatase
Autor: Philip A. Cole, Cecil H. Robinson
Publikováno v: Journal of Medicinal Chemistry. 33:2933-2942
Compilation de 81 references recentes orientees principalement sur la diminution du taux d'œstrogenes par inhibition de leur biosynthese
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::183eba8470d14e5527c0142d5edf55ec
https://doi.org/10.1021/jm00173a001
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10
Synthesis of potential mechanism-based inactivators of lanosterol 14.alpha.-methyl demethylase
Autor: Leah L. Frye, Cecil H. Robinson
Publikováno v: The Journal of Organic Chemistry. 55:1579-1584
Synthese d'alkyl-14 dimethyl-4,4 cholestene-7 ol-3 a partir d'un derive de cyclopenta [1,2] phenanthro [10,1-bc] furanne via un derive de formyl-14 dimethyl-4,4 cholestene-7 ol-3. Ces composes peuvent etre des inhibiteurs potentiels de la lanosterol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ce7dab1097627be1f7bb4dcc45ca98a
https://doi.org/10.1021/jo00292a037
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